P39880: Homeobox protein cut-like 1
Protein names | - Homeobox protein cut-like 1 - CCAAT displacement protein - CDP - Homeobox protein cux-1 |
---|---|
Gene names | CUX1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P39880 |
12
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF
70 80 90 100 110 120
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE
130 140 150 160 170 180
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ
190 200 210 220 230 240
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN
250 260 270 280 290 300
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350 360
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI
370 380 390 400 410 420
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES
430 440 450 460 470 480
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL
490 500 510 520 530 540
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE
550 560 570 580 590 600
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650 660
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI
670 680 690 700 710 720
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ
730 740 750 760 770 780
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN
790 800 810 820 830 840
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE
850 860 870 880 890 900
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950 960
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG
970 980 990 1000 1010 1020
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ
1030 1040 1050 1060 1070 1080
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP
1090 1100 1110 1120 1130 1140
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT
1150 1160 1170 1180 1190 1200
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250 1260
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK
1270 1280 1290 1300 1310 1320
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD
1330 1340 1350 1360 1370 1380
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT
1390 1400 1410 1420 1430 1440
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP
1450 1460 1470 1480 1490 1500
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
Isoforms
- Isoform 2 of Homeobox protein cut-like 1 - Isoform 3 of Homeobox protein cut-like 1 - Isoform 5 of Homeobox protein cut-like 1 - Isoform 6 of Homeobox protein cut-like 1 - Isoform 7 of Homeobox protein cut-like 1 - Isoform 11 of Homeobox protein cut-like 1Sequence View
10 20 30 40 50 60
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF
70 80 90 100 110 120
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE
130 140 150 160 170 180
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ
190 200 210 220 230 240
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN
250 260 270 280 290 300
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350 360
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI
370 380 390 400 410 420
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES
430 440 450 460 470 480
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL
490 500 510 520 530 540
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE
550 560 570 580 590 600
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650 660
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI
670 680 690 700 710 720
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ
730 740 750 760 770 780
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN
790 800 810 820 830 840
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE
850 860 870 880 890 900
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950 960
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG
970 980 990 1000 1010 1020
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ
1030 1040 1050 1060 1070 1080
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP
1090 1100 1110 1120 1130 1140
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT
1150 1160 1170 1180 1190 1200
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250 1260
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK
1270 1280 1290 1300 1310 1320
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD
1330 1340 1350 1360 1370 1380
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT
1390 1400 1410 1420 1430 1440
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP
1450 1460 1470 1480 1490 1500
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
10 20 30 40 50 60
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF
70 80 90 100 110 120
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE
130 140 150 160 170 180
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ
190 200 210 220 230 240
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN
250 260 270 280 290 300
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350 360
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI
370 380 390 400 410 420
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES
430 440 450 460 470 480
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL
490 500 510 520 530 540
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE
550 560 570 580 590 600
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650 660
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI
670 680 690 700 710 720
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ
730 740 750 760 770 780
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN
790 800 810 820 830 840
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE
850 860 870 880 890 900
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950 960
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG
970 980 990 1000 1010 1020
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ
1030 1040 1050 1060 1070 1080
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP
1090 1100 1110 1120 1130 1140
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT
1150 1160 1170 1180 1190 1200
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250 1260
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK
1270 1280 1290 1300 1310 1320
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD
1330 1340 1350 1360 1370 1380
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT
1390 1400 1410 1420 1430 1440
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP
1450 1460 1470 1480 1490 1500
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
10 20 30 40 50 60
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF
70 80 90 100 110 120
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE
130 140 150 160 170 180
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ
190 200 210 220 230 240
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN
250 260 270 280 290 300
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350 360
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI
370 380 390 400 410 420
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES
430 440 450 460 470 480
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL
490 500 510 520 530 540
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE
550 560 570 580 590 600
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650 660
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI
670 680 690 700 710 720
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ
730 740 750 760 770 780
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN
790 800 810 820 830 840
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE
850 860 870 880 890 900
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950 960
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG
970 980 990 1000 1010 1020
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ
1030 1040 1050 1060 1070 1080
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP
1090 1100 1110 1120 1130 1140
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT
1150 1160 1170 1180 1190 1200
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250 1260
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK
1270 1280 1290 1300 1310 1320
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD
1330 1340 1350 1360 1370 1380
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT
1390 1400 1410 1420 1430 1440
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP
1450 1460 1470 1480 1490 1500
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
10 20 30 40 50 60
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF
70 80 90 100 110 120
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE
130 140 150 160 170 180
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ
190 200 210 220 230 240
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN
250 260 270 280 290 300
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350 360
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI
370 380 390 400 410 420
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES
430 440 450 460 470 480
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL
490 500 510 520 530 540
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE
550 560 570 580 590 600
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650 660
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI
670 680 690 700 710 720
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ
730 740 750 760 770 780
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN
790 800 810 820 830 840
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE
850 860 870 880 890 900
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950 960
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG
970 980 990 1000 1010 1020
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ
1030 1040 1050 1060 1070 1080
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP
1090 1100 1110 1120 1130 1140
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT
1150 1160 1170 1180 1190 1200
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250 1260
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK
1270 1280 1290 1300 1310 1320
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD
1330 1340 1350 1360 1370 1380
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT
1390 1400 1410 1420 1430 1440
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP
1450 1460 1470 1480 1490 1500
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
10 20 30 40 50 60
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF
70 80 90 100 110 120
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE
130 140 150 160 170 180
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ
190 200 210 220 230 240
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN
250 260 270 280 290 300
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350 360
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI
370 380 390 400 410 420
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES
430 440 450 460 470 480
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL
490 500 510 520 530 540
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE
550 560 570 580 590 600
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650 660
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI
670 680 690 700 710 720
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ
730 740 750 760 770 780
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN
790 800 810 820 830 840
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE
850 860 870 880 890 900
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950 960
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG
970 980 990 1000 1010 1020
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ
1030 1040 1050 1060 1070 1080
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP
1090 1100 1110 1120 1130 1140
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT
1150 1160 1170 1180 1190 1200
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250 1260
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK
1270 1280 1290 1300 1310 1320
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD
1330 1340 1350 1360 1370 1380
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT
1390 1400 1410 1420 1430 1440
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP
1450 1460 1470 1480 1490 1500
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
10 20 30 40 50 60
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF
70 80 90 100 110 120
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE
130 140 150 160 170 180
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ
190 200 210 220 230 240
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN
250 260 270 280 290 300
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350 360
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI
370 380 390 400 410 420
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES
430 440 450 460 470 480
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL
490 500 510 520 530 540
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE
550 560 570 580 590 600
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650 660
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI
670 680 690 700 710 720
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ
730 740 750 760 770 780
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN
790 800 810 820 830 840
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE
850 860 870 880 890 900
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950 960
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG
970 980 990 1000 1010 1020
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ
1030 1040 1050 1060 1070 1080
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP
1090 1100 1110 1120 1130 1140
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT
1150 1160 1170 1180 1190 1200
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250 1260
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK
1270 1280 1290 1300 1310 1320
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD
1330 1340 1350 1360 1370 1380
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT
1390 1400 1410 1420 1430 1440
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP
1450 1460 1470 1480 1490 1500
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
Protein Neighborhood
Domains & Features
12 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P39880-1-unknown | MLCVAG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P39880-1-unknown | MLCVAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72160 | |||
P39880-1-unknown | MLCVAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72162 | |||
P39880-1-unknown | MLCVAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72163 | |||
P39880-1-unknown | MLCVAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72164 | |||
P39880-377- | AAKPLE... | 377 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P39880-377-unknown | AAKPLE... | 377 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165489 | |||
P39880-377-unknown | AAKPLE... | 377 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165490 | |||
P39880-377-unknown | AAKPLE... | 377 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165491 | |||
P39880-377-unknown | AAKPLE... | 377 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165492 | |||
P39880-377-unknown | AAKPLE... | 377 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165494 | |||
P39880-377-unknown | AAKPLE... | 377 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165493 | |||
P39880-644-unknown | EVPKRR... | 644 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5839 | |||
P39880-644-unknown | EVPKRR... | 644 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153902 | |||
P39880-644-unknown | EVPKRR... | 644 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155384 | |||
P39880-748-unknown | TSPMPT... | 748 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5842 | |||
P39880-748-unknown | TSPMPT... | 748 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154470 | |||
P39880-748-unknown | TSPMPT... | 748 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155254 | |||
P39880-748-unknown | TSPMPT... | 748 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155783 | |||
P39880-748-unknown | TSPMPT... | 748 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156111 | |||
P39880-748-unknown | TSPMPT... | 748 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156309 | |||
P39880-756-unknown | SYPPLA... | 756 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5848 | |||
P39880-756-unknown | SYPPLA... | 756 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154564 | |||
P39880-756-unknown | SYPPLA... | 756 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155366 | |||
P39880-756-unknown | SYPPLA... | 756 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155861 | |||
P39880-756-unknown | SYPPLA... | 756 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156164 | |||
P39880-756-unknown | SYPPLA... | 756 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156346 | |||
P39880-1340-unknown | GVEATE... | 1340 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165086 | |||
P39880-1340-unknown | GVEATE... | 1340 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165088 | |||
P39880-1340-unknown | GVEATE... | 1340 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165087 | |||
P39880-1340-unknown | GVEATE... | 1340 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165090 | |||
P39880-1340-unknown | GVEATE... | 1340 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165089 | |||
P39880-1340- | GVEATE... | 1340 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P39880-1340- | GVEATE... | 1340 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
P39880-1343-unknown | ATEGPG... | 1343 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P39880-1343-unknown | ATEGPG... | 1343 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161424 | |||
P39880-1343-unknown | ATEGPG... | 1343 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161426 | |||
P39880-1343-unknown | ATEGPG... | 1343 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161425 | |||
P39880-1343-unknown | ATEGPG... | 1343 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161428 | |||
P39880-1343-unknown | ATEGPG... | 1343 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161427 | |||
P39880-1343- | ATEGPG... | 1343 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P39880-1343- | ATEGPG... | 1343 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P39880-1343- | ATEGPG... | 1343 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P39880-1444-unknown | SSSSSA... | 1444 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171987 | |||
P39880-1444-unknown | SSSSSA... | 1444 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171989 | |||
P39880-1444-unknown | SSSSSA... | 1444 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171988 | |||
P39880-1444-unknown | SSSSSA... | 1444 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171991 | |||
P39880-1444-unknown | SSSSSA... | 1444 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171990 | |||
P39880-1444- | SSSSSA... | 1444 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...NRLFQE | 643 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5839 | |||
...NRLFQE | 643 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137324 | |||
...NRLFQE | 643 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138819 | |||
...PKLLST | 747 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5842 | |||
...PKLLST | 747 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137892 | |||
...PKLLST | 747 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138686 | |||
...PKLLST | 747 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139233 | |||
...PKLLST | 747 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139574 | |||
...PKLLST | 747 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139781 | |||
...MPTVSS | 755 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5848 | |||
...MPTVSS | 755 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137988 | |||
...MPTVSS | 755 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138800 | |||
...MPTVSS | 755 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139314 | |||
...MPTVSS | 755 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139630 | |||
...MPTVSS | 755 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139821 | |||
...IEWEF | 1505 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...IEWEF | 1505 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt67782 | |||
...IEWEF | 1505 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt67780 | |||
...IEWEF | 1505 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt67781 | |||
...IEWEF | 1505 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt67778 | |||
...IEWEF | 1505 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt67779 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 643 | LFQE.|.EVPK | inferred from experiment | unknown | MEROPS | Nepveu A | Goulet B et al.:A cathepsin L isoform that is d... (C01.032) | 15099520, |
CATL1_HUMAN | 747 | LLST.|.TSPM | inferred from experiment | unknown | MEROPS | Nepveu A | Goulet B et al.:A cathepsin L isoform that is d... (C01.032) | 15099520, |
CATL1_HUMAN | 755 | TVSS.|.SYPP | inferred from experiment | unknown | MEROPS | Nepveu A | Goulet B et al.:A cathepsin L isoform that is d... (C01.032) | 15099520, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|