P61221: ATP-binding cassette sub-family E member 1

General Information

Protein names	- ATP-binding cassette sub-family E member 1 - 2'-5'-oligoadenylate-binding protein - HuHP68 - RNase L inhibitor - Ribonuclease 4 inhibitor - RNS4I
Gene names	ABCE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61221

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI SETLCIGCGI
        70         80         90        100        110        120
CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL
       130        140        150        160        170        180
KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA
       190        200        210        220        230        240
KGTVGSILDR KDETKTQAIV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF
       250        260        270        280        290        300
DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
       310        320        330        340        350        360
MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF
       370        380        390        400        410        420
ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE GGEVPVLNVS YKPQKISPKS
       430        440        450        460        470        480
TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA
       490        500        510        520        530        540
DVYLIDEPSA YLDSEQRLMA ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS
       550        560        570        580        590
KNTVANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61221-1-unknown	MADKLT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61221-2-acetylation	ADKLTR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P61221-2-acetylation	ADKLTR...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P61221-169-unknown	KPQYVD...	169		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6084
P61221-213-	NVEDLS...	213			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P61221-315-	GYVPTE...	315			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKAIIK	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6084
...LTHLKE	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421250
...FFLDD	599	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	168	AIIK.\|.KPQY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)