Q9NVI1: Fanconi anemia group I protein

General Information

Protein names	- Fanconi anemia group I protein - Protein FACI
Gene names	FANCI
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NVI1

5 N-termini

7 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Fanconi anemia group I protein - Isoform 1 of Fanconi anemia group I protein - Isoform 4 of Fanconi anemia group I protein

Sequence View

        10         20         30         40         50         60
MDQKILSLAA EKTADKLQEF LQTLREGDLT NLLQNQAVKG KVAGALLRAI FKGSPCSEEA
        70         80         90        100        110        120
GTLRRRKIYT CCIQLVESGD LQKEIASEII GLLMLEAHHF PGPLLVELAN EFISAVREGS
       130        140        150        160        170        180
LVNGKSLELL PIILTALATK KENLAYGKGV LSGEECKKQL INTLCSGRWD QQYVIQLTSM
       190        200        210        220        230        240
FKDVPLTAEE VEFVVEKALS MFSKMNLQEI PPLVYQLLVL SSKGSRKSVL EGIIAFFSAL
       250        260        270        280        290        300
DKQHNEEQSG DELLDVVTVP SGELRHVEGT IILHIVFAIK LDYELGRELV KHLKVGQQGD
       310        320        330        340        350        360
SNNNLSPFSI ALLLSVTRIQ RFQDQVLDLL KTSVVKSFKD LQLLQGSKFL QNLVPHRSYV
       370        380        390        400        410        420
STMILEVVKN SVHSWDHVTQ GLVELGFILM DSYGPKKVLD GKTIETSPSL SRMPNQHACK
       430        440        450        460        470        480
LGANILLETF KIHEMIRQEI LEQVLNRVVT RASSPISHFL DLLSNIVMYA PLVLQSCSSK
       490        500        510        520        530        540
VTEAFDYLSF LPLQTVQRLL KAVQPLLKVS MSMRDCLILV LRKAMFANQL DARKSAVAGF
       550        560        570        580        590        600
LLLLKNFKVL GSLSSSQCSQ SLSVSQVHVD VHSHYNSVAN ETFCLEIMDS LRRCLSQQAD
       610        620        630        640        650        660
VRLMLYEGFY DVLRRNSQLA NSVMQTLLSQ LKQFYEPKPD LLPPLKLEAC ILTQGDKISL
       670        680        690        700        710        720
QEPLDYLLCC IQHCLAWYKN TVIPLQQGEE EEEEEEAFYE DLDDILESIT NRMIKSELED
       730        740        750        760        770        780
FELDKSADFS QSTSIGIKNN ICAFLVMGVC EVLIEYNFSI SSFSKNRFED ILSLFMCYKK
       790        800        810        820        830        840
LSDILNEKAG KAKTKMANKT SDSLLSMKFV SSLLTALFRD SIQSHQESLS VLRSSNEFMR
       850        860        870        880        890        900
YAVNVALQKV QQLKETGHVS GPDGQNPEKI FQNLCDITRV LLWRYTSIPT SVEESGKKEK
       910        920        930        940        950        960
GKSISLLCLE GLQKIFSAVQ QFYQPKIQQF LRALDVTDKE GEEREDADVS VTQRTAFQIR
       970        980        990       1000       1010       1020
QFQRSLLNLL SSQEEDFNSK EALLLVTVLT SLSKLLEPSS PQFVQMLSWT SKICKENSRE
      1030       1040       1050       1060       1070       1080
DALFCKSLMN LLFSLHVSYK SPVILLRDLS QDIHGHLGDI DQDVEVEKTN HFAIVNLRTA
      1090       1100       1110       1120       1130       1140
APTVCLLVLS QAEKVLEEVD WLITKLKGQV SQETLSEEAS SQATLPNQPV EKAIIMQLGT
      1150       1160       1170       1180       1190       1200
LLTFFHELVQ TALPSGSCVD TLLKDLCKMY TTLTALVRYY LQVCQSSGGI PKNMEKLVKL
      1210       1220       1230       1240       1250       1260
SGSHLTPLCY SFISYVQNKS KSLNYTGEKK EKPAAVATAM ARVLRETKPI PNLIFAIEQY
      1270       1280       1290       1300       1310       1320
EKFLIHLSKK SKVNLMQHMK LSTSRDFKIK GNILDMVLRE DGEDENEEGT ASEHGGQNKE

PAKKKRKK         10         20         30         40         50         60
MDQKILSLAA EKTADKLQEF LQTLREGDLT NLLQNQAVKG KVAGALLRAI FKGSPCSEEA
        70         80         90        100        110        120
GTLRRRKIYT CCIQLVESGD LQKEIASEII GLLMLEAHHF PGPLLVELAN EFISAVREGS
       130        140        150        160        170        180
LVNGKSLELL PIILTALATK KENLAYGKGV LSGEECKKQL INTLCSGRWD QQYVIQLTSM
       190        200        210        220        230        240
FKDVPLTAEE VEFVVEKALS MFSKMNLQEI PPLVYQLLVL SSKGSRKSVL EGIIAFFSAL
       250        260        270        280        290        300
DKQHNEEQSG DELLDVVTVP SGELRHVEGT IILHIVFAIK LDYELGRELV KHLKVGQQGD
       310        320        330        340        350        360
SNNNLSPFSI ALLLSVTRIQ RFQDQVLDLL KTSVVKSFKD LQLLQGSKFL QNLVPHRSYV
       370        380        390        400        410        420
STMILEVVKN SVHSWDHVTQ GLVELGFILM DSYGPKKVLD GKTIETSPSL SRMPNQHACK
       430        440        450        460        470        480
LGANILLETF KIHEMIRQEI LEQVLNRVVT RASSPISHFL DLLSNIVMYA PLVLQSCSSK
       490        500        510        520        530        540
VTEAFDYLSF LPLQTVQRLL KAVQPLLKVS MSMRDCLILV LRKAMFANQL DARKSAVAGF
       550        560        570        580        590        600
LLLLKNFKVL GSLSSSQCSQ SLSVSQVHVD VHSHYNSVAN ETFCLEIMDS LRRCLSQQAD
       610        620        630        640        650        660
VRLMLYEGFY DVLRRNSQLA NSVMQTLLSQ LKQFYEPKPD LLPPLKLEAC ILTQGDKISL
       670        680        690        700        710        720
QEPLDYLLCC IQHCLAWYKN TVIPLQQGEE EEEEEEAFYE DLDDILESIT NRMIKSELED
       730        740        750        760        770        780
FELDKSADFS QSTSIGIKNN ICAFLVMGVC EVLIEYNFSI SSFSKNRFED ILSLFMCYKK
       790        800        810        820        830        840
LSDILNEKAG KAKTKMANKT SDSLLSMKFV SSLLTALFRD SIQSHQESLS VLRSSNEFMR
       850        860        870        880        890        900
YAVNVALQKV QQLKETGHVS GPDGQNPEKI FQNLCDITRV LLWRYTSIPT SVEESGKKEK
       910        920        930        940        950        960
GKSISLLCLE GLQKIFSAVQ QFYQPKIQQF LRALDVTDKE GEEREDADVS VTQRTAFQIR
       970        980        990       1000       1010       1020
QFQRSLLNLL SSQEEDFNSK EALLLVTVLT SLSKLLEPSS PQFVQMLSWT SKICKENSRE
      1030       1040       1050       1060       1070       1080
DALFCKSLMN LLFSLHVSYK SPVILLRDLS QDIHGHLGDI DQDVEVEKTN HFAIVNLRTA
      1090       1100       1110       1120       1130       1140
APTVCLLVLS QAEKVLEEVD WLITKLKGQV SQETLSEEAS SQATLPNQPV EKAIIMQLGT
      1150       1160       1170       1180       1190       1200
LLTFFHELVQ TALPSGSCVD TLLKDLCKMY TTLTALVRYY LQVCQSSGGI PKNMEKLVKL
      1210       1220       1230       1240       1250       1260
SGSHLTPLCY SFISYVQNKS KSLNYTGEKK EKPAAVATAM ARVLRETKPI PNLIFAIEQY
      1270       1280       1290       1300       1310       1320
EKFLIHLSKK SKVNLMQHMK LSTSRDFKIK GNILDMVLRE DGEDENEEGT ASEHGGQNKE

PAKKKRKK         10         20         30         40         50         60
MDQKILSLAA EKTADKLQEF LQTLREGDLT NLLQNQAVKG KVAGALLRAI FKGSPCSEEA
        70         80         90        100        110        120
GTLRRRKIYT CCIQLVESGD LQKEIASEII GLLMLEAHHF PGPLLVELAN EFISAVREGS
       130        140        150        160        170        180
LVNGKSLELL PIILTALATK KENLAYGKGV LSGEECKKQL INTLCSGRWD QQYVIQLTSM
       190        200        210        220        230        240
FKDVPLTAEE VEFVVEKALS MFSKMNLQEI PPLVYQLLVL SSKGSRKSVL EGIIAFFSAL
       250        260        270        280        290        300
DKQHNEEQSG DELLDVVTVP SGELRHVEGT IILHIVFAIK LDYELGRELV KHLKVGQQGD
       310        320        330        340        350        360
SNNNLSPFSI ALLLSVTRIQ RFQDQVLDLL KTSVVKSFKD LQLLQGSKFL QNLVPHRSYV
       370        380        390        400        410        420
STMILEVVKN SVHSWDHVTQ GLVELGFILM DSYGPKKVLD GKTIETSPSL SRMPNQHACK
       430        440        450        460        470        480
LGANILLETF KIHEMIRQEI LEQVLNRVVT RASSPISHFL DLLSNIVMYA PLVLQSCSSK
       490        500        510        520        530        540
VTEAFDYLSF LPLQTVQRLL KAVQPLLKVS MSMRDCLILV LRKAMFANQL DARKSAVAGF
       550        560        570        580        590        600
LLLLKNFKVL GSLSSSQCSQ SLSVSQVHVD VHSHYNSVAN ETFCLEIMDS LRRCLSQQAD
       610        620        630        640        650        660
VRLMLYEGFY DVLRRNSQLA NSVMQTLLSQ LKQFYEPKPD LLPPLKLEAC ILTQGDKISL
       670        680        690        700        710        720
QEPLDYLLCC IQHCLAWYKN TVIPLQQGEE EEEEEEAFYE DLDDILESIT NRMIKSELED
       730        740        750        760        770        780
FELDKSADFS QSTSIGIKNN ICAFLVMGVC EVLIEYNFSI SSFSKNRFED ILSLFMCYKK
       790        800        810        820        830        840
LSDILNEKAG KAKTKMANKT SDSLLSMKFV SSLLTALFRD SIQSHQESLS VLRSSNEFMR
       850        860        870        880        890        900
YAVNVALQKV QQLKETGHVS GPDGQNPEKI FQNLCDITRV LLWRYTSIPT SVEESGKKEK
       910        920        930        940        950        960
GKSISLLCLE GLQKIFSAVQ QFYQPKIQQF LRALDVTDKE GEEREDADVS VTQRTAFQIR
       970        980        990       1000       1010       1020
QFQRSLLNLL SSQEEDFNSK EALLLVTVLT SLSKLLEPSS PQFVQMLSWT SKICKENSRE
      1030       1040       1050       1060       1070       1080
DALFCKSLMN LLFSLHVSYK SPVILLRDLS QDIHGHLGDI DQDVEVEKTN HFAIVNLRTA
      1090       1100       1110       1120       1130       1140
APTVCLLVLS QAEKVLEEVD WLITKLKGQV SQETLSEEAS SQATLPNQPV EKAIIMQLGT
      1150       1160       1170       1180       1190       1200
LLTFFHELVQ TALPSGSCVD TLLKDLCKMY TTLTALVRYY LQVCQSSGGI PKNMEKLVKL
      1210       1220       1230       1240       1250       1260
SGSHLTPLCY SFISYVQNKS KSLNYTGEKK EKPAAVATAM ARVLRETKPI PNLIFAIEQY
      1270       1280       1290       1300       1310       1320
EKFLIHLSKK SKVNLMQHMK LSTSRDFKIK GNILDMVLRE DGEDENEEGT ASEHGGQNKE

PAKKKRKK

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NVI1-1-unknown	MDQKIL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NVI1-1-unknown	MDQKIL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74773
Q9NVI1-1-unknown	MDQKIL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74775
Q9NVI1-94-unknown	MLEAHH...	94	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q9NVI1-94-unknown	MLEAHH...	94	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196848
Q9NVI1-94-unknown	MLEAHH...	94	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196850
Q9NVI1-155-unknown	ECKKQL...	155	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454669
Q9NVI1-155-unknown	ECKKQL...	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197671
Q9NVI1-155-unknown	ECKKQL...	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197673
Q9NVI1-180-unknown	MFKDVP...	180	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390764
Q9NVI1-180-unknown	MFKDVP...	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197890
Q9NVI1-180-unknown	MFKDVP...	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197892
Q9NVI1-824-unknown	SHQESL...	824	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6816

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVNGKS	125	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456552
...LVNGKS	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154665
...LVNGKS	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154667
...GEECKK	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455735
...GEECKK	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155050
...GEECKK	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155052
...PPLVYQ	215	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457029
...PPLVYQ	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155759
...PPLVYQ	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155761
...QSGDEL	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70393
...QSGDEL	252	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458024
...QSGDEL	252	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390764
...QSGDEL	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92102
...RDSIQS	823	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6816
...EPAKKK	1324	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455189
...KKRKK	1328	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KKRKK	1328	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70391

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	823	SIQS.\|.SHQE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)