P00918: Carbonic anhydrase 2

General Information

Protein names	- Carbonic anhydrase 2 - 4.2.1.1 - Carbonate dehydratase II - Carbonic anhydrase C - CAC - Carbonic anhydrase II - CA-II
Gene names	CA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00918

12 N-termini

5 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS YDQATSLRIL
        70         80         90        100        110        120
NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL DGQGSEHTVD KKKYAAELHL
       130        140        150        160        170        180
VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG SAKPGLQKVV DVLDSIKTKG KSADFTNFDP
       190        200        210        220        230        240
RGLLPESLDY WTYPGSLTTP PLLECVTWIV LKEPISVSSE QVLKFRKLNF NGEGEPEELM
       250        260
VDNWRPAQPL KNRQIKASFK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 5 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P00918-2-unknown	MSHHWG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00918-2-Acetylation	SHHWGY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00918-37-	TAKYDP...	37			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00918-40-acetylation	YDPSLK...	40	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00918-48-acetylation	SVSYDQ...	48	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00918-62-unknown	NGHAFN...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7112
P00918-62-unknown	NGHAFN...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5341
P00918-97-unknown	WGSLDG...	97		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5342
P00918-98-unknown	GSLDGQ...	98		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3328
P00918-98-unknown	GSLDGQ...	98		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5343
P00918-99-unknown	SLDGQG...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7113
P00918-99-unknown	SLDGQG...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5344
P00918-172-	SADFTN...	172			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00918-227-	KLNFNG...	227			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00918-227-acetylation	KLNFNG...	227	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRILNN	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7112
...LRILNN	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5341
...QFHFHW	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5342
...FHFHWG	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3328
...FHFHWG	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5343
...HFHWGS	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7113
...HFHWGS	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5344
...KASFK	260	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	61	ILNN.\|.NGHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	61	ILNN.\|.NGHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	96	HFHW.\|.WGSL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	97	FHWG.\|.GSLD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	97	FHWG.\|.GSLD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	98	HWGS.\|.SLDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	98	HWGS.\|.SLDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)