Q6PKG0: La-related protein 1
Protein names | - La-related protein 1 - La ribonucleoprotein domain family member 1 |
---|---|
Gene names | LARP1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q6PKG0 |
20
N-termini
13
C-termini
7
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD GSARRPRPPC
70 80 90 100 110 120
AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG AGGGAAGAAG AGRRDFVEAP
130 140 150 160 170 180
PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP AKVVRAAVPK QRKGSKVGDF GDAINWPTPG
190 200 210 220 230 240
EIAHKSVQPQ SHKPQPTRKL PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR
250 260 270 280 290 300
GGQKKKGNKH KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA
310 320 330 340 350 360
PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR GRGGTRTHFD
370 380 390 400 410 420
YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ ELLKDYIKRQ IEYYFSVDNL
430 440 450 460 470 480
ERDFFLRRKM DADGFLPITL IASFHRVQAL TTDISLIFAA LKDSKVVEIV DEKVRRREEP
490 500 510 520 530 540
EKWPLPPIVD YSQTDFSQLL NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT
550 560 570 580 590 600
LPKGLSASLP DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD
610 620 630 640 650 660
EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP HYMRRHPGGD
670 680 690 700 710 720
RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS QIKQEVENFK KVNMISREQF
730 740 750 760 770 780
DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL ANKLFGAPEP STIARSLPTT VPESPNYRNT
790 800 810 820 830 840
RTPRTPRTPQ LKDSSQTSRF YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE
850 860 870 880 890 900
HRPRTASISS SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE
910 920 930 940 950 960
RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG LECLFRYYSY
970 980 990 1000 1010 1020
GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS KAKNLDIDPK LQEYLGKFRR
1030 1040 1050 1060 1070 1080
LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG RKRCPSQSSS RPAAMISQPP TPPTGQPVRE
1090
DAKWTSQHSN TQTLGK
Isoforms
- Isoform 2 of La-related protein 1Sequence View
10 20 30 40 50 60
MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD GSARRPRPPC
70 80 90 100 110 120
AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG AGGGAAGAAG AGRRDFVEAP
130 140 150 160 170 180
PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP AKVVRAAVPK QRKGSKVGDF GDAINWPTPG
190 200 210 220 230 240
EIAHKSVQPQ SHKPQPTRKL PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR
250 260 270 280 290 300
GGQKKKGNKH KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA
310 320 330 340 350 360
PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR GRGGTRTHFD
370 380 390 400 410 420
YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ ELLKDYIKRQ IEYYFSVDNL
430 440 450 460 470 480
ERDFFLRRKM DADGFLPITL IASFHRVQAL TTDISLIFAA LKDSKVVEIV DEKVRRREEP
490 500 510 520 530 540
EKWPLPPIVD YSQTDFSQLL NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT
550 560 570 580 590 600
LPKGLSASLP DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD
610 620 630 640 650 660
EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP HYMRRHPGGD
670 680 690 700 710 720
RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS QIKQEVENFK KVNMISREQF
730 740 750 760 770 780
DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL ANKLFGAPEP STIARSLPTT VPESPNYRNT
790 800 810 820 830 840
RTPRTPRTPQ LKDSSQTSRF YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE
850 860 870 880 890 900
HRPRTASISS SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE
910 920 930 940 950 960
RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG LECLFRYYSY
970 980 990 1000 1010 1020
GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS KAKNLDIDPK LQEYLGKFRR
1030 1040 1050 1060 1070 1080
LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG RKRCPSQSSS RPAAMISQPP TPPTGQPVRE
1090
DAKWTSQHSN TQTLGK
Protein Neighborhood
Domains & Features
20 N-termini - 13 C-termini - 7 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6PKG0-2-unknown | MATQVE... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q6PKG0-2-Acetylation | ATQVEP... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q6PKG0-2-Acetylation | ATQVEP... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q6PKG0-2-Acetylation | ATQVEP... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
Q6PKG0-2-Acetylation | ATQVEP... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q6PKG0-139-unknown | VNGQSP... | 139 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4144 | |||
Q6PKG0-141-unknown | GQSPPE... | 141 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6558 | |||
Q6PKG0-141-unknown | GQSPPE... | 141 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7922 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | RMPI_untreated | 23264352 | |||
Q6PKG0-173- | AINWPT... | 173 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q6PKG0-173-unknown | AINWPT... | 173 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12615 | |||
Q6PKG0-173-unknown | AINWPT... | 173 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q6PKG0-173-unknown | AINWPT... | 173 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142164 | |||
Q6PKG0-206-unknown | MKEQEK... | 206 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000429710 | |||
Q6PKG0-206-unknown | MKEQEK... | 206 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000429904 | |||
Q6PKG0-206-unknown | MKEQEK... | 206 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198105 | |||
Q6PKG0-226-unknown | DESGEE... | 226 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000430438 | |||
Q6PKG0-226-unknown | DESGEE... | 226 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198297 | |||
Q6PKG0-367-unknown | KFDGVE... | 367 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169943 | |||
Q6PKG0-367- | KFDGVE... | 367 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q6PKG0-394-unknown | ELYSVD... | 394 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000431072 | |||
Q6PKG0-394-unknown | ELYSVD... | 394 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt199311 | |||
Q6PKG0-584-unknown | SLPQQL... | 584 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167479 | |||
Q6PKG0-584- | SLPQQL... | 584 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q6PKG0-584- | SLPQQL... | 584 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q6PKG0-607-unknown | FLFDEE... | 607 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12617 | |||
Q6PKG0-607-unknown | FLFDEE... | 607 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153751 | |||
Q6PKG0-607- | FLFDEE... | 607 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6PKG0-690-unknown | LWAEKF... | 690 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12619 | |||
Q6PKG0-690-unknown | LWAEKF... | 690 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154793 | |||
Q6PKG0-748-unknown | DALANK... | 748 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14628 | |||
Q6PKG0-748-unknown | DALANK... | 748 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155553 | |||
Q6PKG0-756- | GAPEPS... | 756 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q6PKG0-756-unknown | GAPEPS... | 756 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173741 | |||
Q6PKG0-800-unknown | FYPVVK... | 800 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q6PKG0-800-unknown | FYPVVK... | 800 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161751 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PVLTTV | 138 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4144 | |||
...LTTVNG | 140 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6558 | |||
...LTTVNG | 140 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7922 | |||
...GDFGDA | 172 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12615 | |||
...GDFGDA | 172 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125351 | |||
...KPEVPR | 264 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000429852 | |||
...SATYVP | 297 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000429710 | |||
...QIEYYF | 414 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000427731 | |||
...ARPKKS | 573 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000430438 | |||
...QLMSKD | 597 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000431072 | |||
...QEELDF | 606 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12617 | |||
...QEELDF | 606 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137173 | |||
...YYEQDL | 689 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12619 | |||
...YYEQDL | 689 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138219 | |||
...QQVPTD | 747 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14628 | |||
...QQVPTD | 747 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138991 | |||
...DAKMPR | 815 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000428589 | |||
...DAKMPR | 815 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000429904 | |||
...QTLGK | 1096 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...QTLGK | 1096 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt74998 |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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