O60684: Importin subunit alpha-7

General Information

Protein names	- Importin subunit alpha-7 - Karyopherin subunit alpha-6
Gene names	KPNA6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60684

9 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
METMASPGKD NYRMKSYKNN ALNPEEMRRR REEEGIQLRK QKREQQLFKR RNVELINEEA
        70         80         90        100        110        120
AMFDSLLMDS YVSSTTGESV ITREMVEMLF SDDSDLQLAT TQKFRKLLSK EPSPPIDEVI
       130        140        150        160        170        180
NTPRVVDRFV EFLKRNENCT LQFEAAWALT NIASGTSQQT KIVIEAGAVP IFIELLNSDF
       190        200        210        220        230        240
EDVQEQAVWA LGNIAGDSSV CRDYVLNCSI LNPLLTLLTK STRLTMTRNA VWALSNLCRG
       250        260        270        280        290        300
KNPPPEFAKV SPCLPVLSRL LFSSDSDLLA DACWALSYLS DGPNEKIQAV IDSGVCRRLV
       310        320        330        340        350        360
ELLMHNDYKV ASPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSPKE SIRKEACWTI
       370        380        390        400        410        420
SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEAAW AITNATSGGT PEQIRYLVSL
       430        440        450        460        470        480
GCIKPLCDLL TVMDSKIVQV ALNGLENILR LGEQEGKRSG SGVNPYCGLI EEAYGLDKIE
       490        500        510        520        530
FLQSHENQEI YQKAFDLIEH YFGVEDDDSS LAPQVDETQQ QFIFQQPEAP MEGFQL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60684-1-Acetylation	METMAS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60684-1-Acetylation	METMAS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O60684-1-Acetylation	METMAS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60684-1-Acetylation	METMAS...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O60684-2-acetylation	ETMASP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O60684-4-unknown	MASPGK...	4		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444930
O60684-50-unknown	RRNVEL...	50		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415677
O60684-65-unknown	SLLMDS...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10838
O60684-70-	SYVSST...	70			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60684-70-	SYVSST...	70			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60684-70-unknown	SYVSST...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10839
O60684-483-unknown	QSHENQ...	483		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7044
O60684-484-unknown	SHENQE...	484		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5202
O60684-484-unknown	SHENQE...	484		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7045

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AAMFDS	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10838
...SLLMDS	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10839
...TPEQIR	414	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415677
...KIEFLQ	482	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7044
...IEFLQS	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5202
...IEFLQS	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7045
...EGFQL	536	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	64	MFDS.\|.SLLM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	69	LMDS.\|.SYVS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	482	EFLQ.\|.QSHE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	483	FLQS.\|.SHEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	483	FLQS.\|.SHEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)