O14776: Transcription elongation regulator 1

General Information

Protein names	- Transcription elongation regulator 1 - TATA box-binding protein-associated factor 2S - Transcription factor CA150
Gene names	TCERG1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14776

9 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAERGGDGGE SERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP PPFGMMRGPP
        70         80         90        100        110        120
PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM PPPMSSMPPP PGMMFPPGMP
       130        140        150        160        170        180
PVTAPGTPAL PPTEEIWVEN KTPDGKVYYY NARTRESAWT KPDGVKVIQQ SELTPMLAAQ
       190        200        210        220        230        240
AQVQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ
       250        260        270        280        290        300
AQVQAQVQAQ VQAQAVGAST PTTSSPAPAV STSTSSSTPS STTSTTTTAT SVAQTVSTPT
       310        320        330        340        350        360
TQDQTPSSAV SVATPTVSVS TPAPTATPVQ TVPQPHPQTL PPAVPHSVPQ PTTAIPAFPP
       370        380        390        400        410        420
VMVPPFRVPL PGMPIPLPGV AMMQIVSCPY VKTVATTKTG VLPGMAPPIV PMIHPQVAIA
       430        440        450        460        470        480
ASPATLAGAT AVSEWTEYKT ADGKTYYYNN RTLESTWEKP QELKEKEKLE EKIKEPIKEP
       490        500        510        520        530        540
SEEPLPMETE EEDPKEEPIK EIKEEPKEEE MTEEEKAAQK AKPVATAPIP GTPWCVVWTG
       550        560        570        580        590        600
DERVFFYNPT TRLSMWDRPD DLIGRADVDK IIQEPPHKKG MEELKKLRHP TPTMLSIQKW
       610        620        630        640        650        660
QFSMSAIKEE QELMEEINED EPVKAKKRKR DDNKDIDSEK EAAMEAEIKA ARERAIVPLE
       670        680        690        700        710        720
ARMKQFKDML LERGVSAFST WEKELHKIVF DPRYLLLNPK ERKQVFDQYV KTRAEEERRE
       730        740        750        760        770        780
KKNKIMQAKE DFKKMMEEAK FNPRATFSEF AAKHAKDSRF KAIEKMKDRE ALFNEFVAAA
       790        800        810        820        830        840
RKKEKEDSKT RGEKIKSDFF ELLSNHHLDS QSRWSKVKDK VESDPRYKAV DSSSMREDLF
       850        860        870        880        890        900
KQYIEKIAKN LDSEKEKELE RQARIEASLR EREREVQKAR SEQTKEIDRE REQHKREEAI
       910        920        930        940        950        960
QNFKALLSDM VRSSDVSWSD TRRTLRKDHR WESGSLLERE EKEKLFNEHI EALTKKKREH
       970        980        990       1000       1010       1020
FRQLLDETSA ITLTSTWKEV KKIIKEDPRC IKFSSSDRKK QREFEEYIRD KYITAKADFR
      1030       1040       1050       1060       1070       1080
TLLKETKFIT YRSKKLIQES DQHLKDVEKI LQNDKRYLVL DCVPEERRKL IVAYVDDLDR
      1090
RGPPPPPTAS EPTRRSTK

Isoforms

- Isoform 2 of Transcription elongation regulator 1

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14776-1-unknown	MAERGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14776-1-unknown	MAERGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91767
O14776-419-unknown	IAASPA...	419	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175567
O14776-419-	IAASPA...	419		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14776-455-unknown	STWEKP...	455	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5109
O14776-455-unknown	STWEKP...	455	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152547
O14776-605-unknown	SAIKEE...	605	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13712
O14776-605-unknown	SAIKEE...	605	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154384
O14776-605-	SAIKEE...	605		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O14776-606-unknown	AIKEEQ...	606	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173751
O14776-606-	AIKEEQ...	606		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14776-606-	AIKEEQ...	606		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O14776-948-unknown	EHIEAL...	948	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5111
O14776-948-unknown	EHIEAL...	948	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157000

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NRTLES	454	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5109
...NRTLES	454	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135961
...WQFSMS	604	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13712
...WQFSMS	604	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137805
...EKLFNE	947	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5111
...EKLFNE	947	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140491
...RRSTK	1098	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RRSTK	1098	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87385

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	454	TLES.\|.STWE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	604	FSMS.\|.SAIK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	947	LFNE.\|.EHIE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)