Q9Y230: RuvB-like 2

General Information

Protein names	- RuvB-like 2 - 3.6.4.12 - 48 kDa TATA box-binding protein-interacting protein - 48 kDa TBP-interacting protein - 51 kDa erythrocyte cytosolic protein - ECP-51 - INO80 complex subunit J - Repressing pontin 52 - Reptin 52 - TIP49b - TIP60-associated protein 54-beta - TAP54-beta
Gene names	RUVBL2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y230

5 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL
        70         80         90        100        110        120
EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT
       130        140        150        160        170        180
QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE
       190        200        210        220        230        240
SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH
       250        260        270        280        290        300
TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE
       310        320        330        340        350        360
VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT
       370        380        390        400        410        420
PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE
       430        440        450        460
VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTS

Isoforms

- Isoform 2 of RuvB-like 2

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y230-2-unknown	MATVTA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y230-2-Acetylation	ATVTAT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y230-2-Acetylation	ATVTAT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y230-2-Acetylation	ATVTAT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9Y230-2-Acetylation	ATVTAT...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9Y230-30-	GLGLDD...	30			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y230-30-	GLGLDD...	30			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9Y230-30-	GLGLDD...	30			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y230-46-unknown	MVGQLA...	46		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471524
Q9Y230-46-unknown	MVGQLA...	46		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469189
Q9Y230-46-unknown	MVGQLA...	46		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413890
Q9Y230-342-unknown	SPHGIP...	342		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6873

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PATGTG	154	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469189
...GTSYQS	341	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6873
...TMDTS	463	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TMDTS	463		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TMDTS	463		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	341	SYQS.\|.SPHG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)