Q9BY44: Eukaryotic translation initiation factor 2A

General Information

Protein names	- Eukaryotic translation initiation factor 2A - eIF-2A - 65 kDa eukaryotic translation initiation factor 2A - Eukaryotic translation initiation factor 2A, N-terminally processed
Gene names	EIF2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BY44

7 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 2A - Isoform 3 of Eukaryotic translation initiation factor 2A - Isoform 4 of Eukaryotic translation initiation factor 2A

Sequence View

        10         20         30         40         50         60
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRESGKNCK VCIFSKDGTL FAWGNGEKVN
        70         80         90        100        110        120
IISVTNKGLL HSFDLLKAVC LEFSPKNTVL ATWQPYTTSK DGTAGIPNLQ LYDVKTGTCL
       130        140        150        160        170        180
KSFIQKKMQN WCPSWSEDET LCARNVNNEV HFFENNNFNT IANKLHLQKI NDFVLSPGPQ
       190        200        210        220        230        240
PYKVAVYVPG SKGAPSFVRL YQYPNFAGPH AALANKSFFK ADKVTMLWNK KATAVLVIAS
       250        260        270        280        290        300
TDVDKTGASY YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT
       310        320        330        340        350        360
IFNLKCDPVF DFGTGPRNAA YYSPHGHILV LAGFGNLRGQ MEVWDVKNYK LISKPVASDS
       370        380        390        400        410        420
TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSILHKY DVPSNAELWQ VSWQPFLDGI
       430        440        450        460        470        480
FPAKTITYQA VPSEVPNEEP KVATAYRPPA LRNKPITNSK LHEEEPPQNM KPQSGNDKPL
       490        500        510        520        530        540
SKTALKNQRK HEAKKAAKQE ARSDKSPDLA PTPAPQSTPR NTVSQSISGD PEIDKKIKNL
       550        560        570        580
KKKLKAIEQL KEQAATGKQL EKNQLEKIQK ETALLQELED LELGI         10         20         30         40         50         60
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRESGKNCK VCIFSKDGTL FAWGNGEKVN
        70         80         90        100        110        120
IISVTNKGLL HSFDLLKAVC LEFSPKNTVL ATWQPYTTSK DGTAGIPNLQ LYDVKTGTCL
       130        140        150        160        170        180
KSFIQKKMQN WCPSWSEDET LCARNVNNEV HFFENNNFNT IANKLHLQKI NDFVLSPGPQ
       190        200        210        220        230        240
PYKVAVYVPG SKGAPSFVRL YQYPNFAGPH AALANKSFFK ADKVTMLWNK KATAVLVIAS
       250        260        270        280        290        300
TDVDKTGASY YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT
       310        320        330        340        350        360
IFNLKCDPVF DFGTGPRNAA YYSPHGHILV LAGFGNLRGQ MEVWDVKNYK LISKPVASDS
       370        380        390        400        410        420
TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSILHKY DVPSNAELWQ VSWQPFLDGI
       430        440        450        460        470        480
FPAKTITYQA VPSEVPNEEP KVATAYRPPA LRNKPITNSK LHEEEPPQNM KPQSGNDKPL
       490        500        510        520        530        540
SKTALKNQRK HEAKKAAKQE ARSDKSPDLA PTPAPQSTPR NTVSQSISGD PEIDKKIKNL
       550        560        570        580
KKKLKAIEQL KEQAATGKQL EKNQLEKIQK ETALLQELED LELGI         10         20         30         40         50         60
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRESGKNCK VCIFSKDGTL FAWGNGEKVN
        70         80         90        100        110        120
IISVTNKGLL HSFDLLKAVC LEFSPKNTVL ATWQPYTTSK DGTAGIPNLQ LYDVKTGTCL
       130        140        150        160        170        180
KSFIQKKMQN WCPSWSEDET LCARNVNNEV HFFENNNFNT IANKLHLQKI NDFVLSPGPQ
       190        200        210        220        230        240
PYKVAVYVPG SKGAPSFVRL YQYPNFAGPH AALANKSFFK ADKVTMLWNK KATAVLVIAS
       250        260        270        280        290        300
TDVDKTGASY YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT
       310        320        330        340        350        360
IFNLKCDPVF DFGTGPRNAA YYSPHGHILV LAGFGNLRGQ MEVWDVKNYK LISKPVASDS
       370        380        390        400        410        420
TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSILHKY DVPSNAELWQ VSWQPFLDGI
       430        440        450        460        470        480
FPAKTITYQA VPSEVPNEEP KVATAYRPPA LRNKPITNSK LHEEEPPQNM KPQSGNDKPL
       490        500        510        520        530        540
SKTALKNQRK HEAKKAAKQE ARSDKSPDLA PTPAPQSTPR NTVSQSISGD PEIDKKIKNL
       550        560        570        580
KKKLKAIEQL KEQAATGKQL EKNQLEKIQK ETALLQELED LELGI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BY44-1-Acetylation	MAPSTP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BY44-1-Acetylation	MAPSTP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BY44-1-Acetylation	MAPSTP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BY44-2-unknown	APSTPL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BY44-2-unknown	APSTPL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BY44-2-Acetylation	APSTPL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BY44-2-	APSTPL...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BY44-208-unknown	GPHAAL...	208		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6756
Q9BY44-509-unknown	LAPTPA...	509		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14972
Q9BY44-509-unknown	LAPTPA...	509		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149738
Q9BY44-525-unknown	QSISGD...	525		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8072
Q9BY44-525-unknown	QSISGD...	525		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150140

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YPNFAG	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6756
...DKSPDL	508	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14972
...DKSPDL	508	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133127
...RNTVSQ	524	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8072
...RNTVSQ	524	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133532
...LELGI	585	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LELGI	585	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69381

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	207	NFAG.\|.GPHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	508	SPDL.\|.LAPT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	524	TVSQ.\|.QSIS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)