Q8WXF1: Paraspeckle component 1

General Information

Protein names	- Paraspeckle component 1 - Paraspeckle protein 1
Gene names	PSPC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WXF1

11 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMLRGNLKQV RIEKNPARLR ALESAVGESE PAAAAAMALA LAGEPAPPAP APPEDHPDEE
        70         80         90        100        110        120
MGFTIDIKSF LKPGEKTYTQ RCRLFVGNLP TDITEEDFKR LFERYGEPSE VFINRDRGFG
       130        140        150        160        170        180
FIRLESRTLA EIAKAELDGT ILKSRPLRIR FATHGAALTV KNLSPVVSNE LLEQAFSQFG
       190        200        210        220        230        240
PVEKAVVVVD DRGRATGKGF VEFAAKPPAR KALERCGDGA FLLTTTPRPV IVEPMEQFDD
       250        260        270        280        290        300
EDGLPEKLMQ KTQQYHKERE QPPRFAQPGT FEFEYASRWK ALDEMEKQQR EQVDRNIREA
       310        320        330        340        350        360
KEKLEAEMEA ARHEHQLMLM RQDLMRRQEE LRRLEELRNQ ELQKRKQIQL RHEEEHRRRE
       370        380        390        400        410        420
EEMIRHREQE ELRRQQEGFK PNYMENREQE MRMGDMGPRG AINMGDAFSP APAGNQGPPP
       430        440        450        460        470        480
MMGMNMNNRA TIPGPPMGPG PAMGPEGAAN MGTPMMPDNG AVHNDRFPQG PPSQMGSPMG
       490        500        510        520
SRTGSETPQA PMSGVGPVSG GPGGFGRGSQ GGNFEGPNKR RRY

Isoforms

- Isoform 2 of Paraspeckle component 1

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WXF1-1-Acetylation	MMLRGN...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WXF1-1-Acetylation	MMLRGN...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106588
Q8WXF1-1-unknown	MMLRGN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86423
Q8WXF1-40-unknown	ALAGEP...	40		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171911
Q8WXF1-40-	ALAGEP...	40			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WXF1-43-unknown	GEPAPP...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171913
Q8WXF1-43-	GEPAPP...	43			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WXF1-43-	GEPAPP...	43			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8WXF1-43-	GEPAPP...	43			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8WXF1-87-unknown	GNLPTD...	87		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6619
Q8WXF1-87-unknown	GNLPTD...	87		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141681
Q8WXF1-185-unknown	AVVVVD...	185		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172722
Q8WXF1-185-	AVVVVD...	185			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WXF1-407-	AFSPAP...	407			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8WXF1-461-	AVHNDR...	461			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CRLFVG	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6619
...CRLFVG	86	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124863
...KRRRY	523	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	86	LFVG.\|.GNLP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)