Q9NP61: ADP-ribosylation factor GTPase-activating protein 3

General Information

Protein names	- ADP-ribosylation factor GTPase-activating protein 3 - ARF GAP 3
Gene names	ARFGAP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NP61

17 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGDPSKQDIL TIFKRLRSVP TNKVCFDCGA KNPSWASITY GVFLCIDCSG SHRSLGVHLS
        70         80         90        100        110        120
FIRSTELDSN WSWFQLRCMQ VGGNASASSF FHQHGCSTND TNAKYNSRAA QLYREKIKSL
       130        140        150        160        170        180
ASQATRKHGT DLWLDSCVVP PLSPPPKEED FFASHVSPEV SDTAWASAIA EPSSLTSRPV
       190        200        210        220        230        240
ETTLENNEGG QEQGPSVEGL NVPTKATLEV SSIIKKKPNQ AKKGLGAKKG SLGAQKLANT
       250        260        270        280        290        300
CFNEIEKQAQ AADKMKEQED LAKVVSKEES IVSSLRLAYK DLEIQMKKDE KMNISGKKNV
       310        320        330        340        350        360
DSDRLGMGFG NCRSVISHSV TSDMQTIEQE SPIMAKPRKK YNDDSDDSYF TSSSSYFDEP
       370        380        390        400        410        420
VELRSSSFSS WDDSSDSYWK KETSKDTETV LKTTGYSDRP TARRKPDYEP VENTDEAQKK
       430        440        450        460        470        480
FGNVKAISSD MYFGRQSQAD YETRARLERL SASSSISSAD LFEEPRKQPA GNYSLSSVLP
       490        500        510
NAPDMAQFKQ GVRSVAGKLS VFANGVVTSI QDRYGS

Isoforms

- Isoform 2 of ADP-ribosylation factor GTPase-activating protein 3

Sequence View

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Protein Neighborhood

Domains & Features

17 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NP61-1-unknown	MGDPSK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NP61-1-unknown	MGDPSK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67325
Q9NP61-2-acetylation	GDPSKQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NP61-2-acetylation	GDPSKQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NP61-2-acetylation	GDPSKQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162389
Q9NP61-154-unknown	SHVSPE...	154		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6791
Q9NP61-154-unknown	SHVSPE...	154		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142942
Q9NP61-168-	AIAEPS...	168			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NP61-168-	AIAEPS...	168			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NP61-168-unknown	AIAEPS...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171124
Q9NP61-169-	IAEPSS...	169			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NP61-169-unknown	IAEPSS...	169		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175252
Q9NP61-314-	SVISHS...	314			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NP61-314-unknown	SVISHS...	314		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172328
Q9NP61-322-unknown	SDMQTI...	322		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167492
Q9NP61-322-	SDMQTI...	322			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NP61-389-	TVLKTT...	389			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NP61-389-unknown	TVLKTT...	389		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167494
Q9NP61-426-	AISSDM...	426			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NP61-426-unknown	AISSDM...	426		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178500
Q9NP61-452-	ASSSIS...	452			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NP61-452-unknown	ASSSIS...	452		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172330

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDFFAS	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6791
...EDFFAS	153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126152
...DRYGS	516	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DRYGS	516	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62943

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	153	FFAS.\|.SHVS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)