TopFIND 4.0

P04080: Cystatin-B

General Information

Protein names	- Cystatin-B - CPI-B - Liver thiol proteinase inhibitor - Stefin-B
Gene names	CSTB
Organism	Homo sapiens
Protease Family
Protease ID	I25.003
Chromosome location
UniProt ID	P04080

7

N-termini

4

C-termini

4

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG
70 80 90
DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04080-1-Acetylation	MMCGAP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04080-1-Acetylation	MMCGAP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P04080-1-Acetylation	MMCGAP...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P04080-1-Acetylation	MMCGAP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P04080-1-Acetylation	MMCGAP...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P04080-4-	GAPSAT...	4			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04080-4-unknown	GAPSAT...	4			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P04080-5-unknown	APSATQ...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17085
P04080-10-unknown	QPATAE...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7192
P04080-15-unknown	ETQHIA...	15		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7193
P04080-72-unknown	SLPHEN...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5381

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...APSATQ	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7192
	...QPATAE	14	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7193
	...LRVFQS	71	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5381
	...ELTYF	98	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	4	MCGA.\|.APSA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	9	SATQ.\|.QPAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	14	ATAE.\|.ETQH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	71	VFQS.\|.SLPH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)