P04818: Thymidylate synthase

General Information

Protein names	- Thymidylate synthase - TS - TSase - 2.1.1.45
Gene names	TYMS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04818

10 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Thymidylate synthase - Isoform 3 of Thymidylate synthase

Sequence View

        10         20         30         40         50         60
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG
        70         80         90        100        110        120
MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS
       130        140        150        160        170        180
LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC
       190        200        210        220        230        240
AWNPRDLPLM ALPPCHALCQ FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI
       250        260        270        280        290        300
TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG
       310
YNPHPTIKME MAV         10         20         30         40         50         60
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG
        70         80         90        100        110        120
MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS
       130        140        150        160        170        180
LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC
       190        200        210        220        230        240
AWNPRDLPLM ALPPCHALCQ FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI
       250        260        270        280        290        300
TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG
       310
YNPHPTIKME MAV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04818-1-unknown	MPVAGS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93499
P04818-1-unknown	MPVAGS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93500
P04818-2-unknown	PVAGSE...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04818-2-unknown	PVAGSE...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P04818-2-unknown	PVAGSE...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P04818-2-unknown	PVAGSE...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111750
P04818-2-unknown	PVAGSE...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111751
P04818-3-unknown	VAGSEL...	3		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P04818-3-unknown	VAGSEL...	3		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P04818-3-unknown	VAGSEL...	3	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160374
P04818-3-unknown	VAGSEL...	3	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160375
P04818-3-	VAGSEL...	3		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P04818-3-	VAGSEL...	3		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P04818-3-	VAGSEL...	3		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P04818-3-	VAGSEL...	3		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P04818-3-	VAGSEL...	3		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P04818-3-	VAGSEL...	3		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04818-22-	AEPRPP...	22		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04818-22-unknown	AEPRPP...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173909
P04818-22-unknown	AEPRPP...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173910
P04818-61-unknown	MQARYS...	61	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P04818-61-unknown	MQARYS...	61	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196337
P04818-120-	SLGFST...	120		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P04818-120-	SLGFST...	120		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04818-120-unknown	SLGFST...	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167477
P04818-300-unknown	GYNPHP...	300	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5390
P04818-300-unknown	GYNPHP...	300	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147208
P04818-300-unknown	GYNPHP...	300	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149009

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DFQIEG	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5390
...DFQIEG	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130548
...DFQIEG	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132392
...MEMAV	313	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MEMAV	313	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89118
...MEMAV	313	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89117

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	299	QIEG.\|.GYNP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)