Q9Y4X5: E3 ubiquitin-protein ligase ARIH1

General Information

Protein names	- E3 ubiquitin-protein ligase ARIH1 - 2.3.2.31 {ECO:0000269\|PubMed:15236971, ECO:0000269\|PubMed:21532592, ECO:0000269\|PubMed:27565346} - H7-AP2 {ECO:0000303\|PubMed:10521492} - HHARI {ECO:0000303\|PubMed:11278816} - Monocyte protein 6 {ECO:0000303\|Ref.10} - MOP-6 {ECO:0000303\|Ref.10} - Protein ariadne-1 homolog {ECO:0000303\|Ref.3} - ARI-1 {ECO:0000303\|Ref.3} - UbcH7-binding protein {ECO:0000303\|PubMed:11278816} - UbcM4-interacting protein - Ubiquitin-conjugating enzyme E2-binding protein 1 {ECO:0000303\|PubMed:10521492}
Gene names	ARIH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y4X5

3 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDSDEGYNYE FDEDEECSEE DSGAEEEEDE DDDEPDDDTL DLGEVELVEP GLGVGGERDG
        70         80         90        100        110        120
LLCGETGGGG GSALGPGGGG GGGGGGGGGG PGHEQEEDYR YEVLTAEQIL QHMVECIREV
       130        140        150        160        170        180
NEVIQNPATI TRILLSHFNW DKEKLMERYF DGNLEKLFAE CHVINPSKKS RTRQMNTRSS
       190        200        210        220        230        240
AQDMPCQICY LNYPNSYFTG LECGHKFCMQ CWSEYLTTKI MEEGMGQTIS CPAHGCDILV
       250        260        270        280        290        300
DDNTVMRLIT DSKVKLKYQH LITNSFVECN RLLKWCPAPD CHHVVKVQYP DAKPVRCKCG
       310        320        330        340        350        360
RQFCFNCGEN WHDPVKCKWL KKWIKKCDDD SETSNWIAAN TKECPKCHVT IEKDGGCNHM
       370        380        390        400        410        420
VCRNQNCKAE FCWVCLGPWE PHGSAWYNCN RYNEDDAKAA RDAQERSRAA LQRYLFYCNR
       430        440        450        460        470        480
YMNHMQSLRF EHKLYAQVKQ KMEEMQQHNM SWIEVQFLKK AVDVLCQCRA TLMYTYVFAF
       490        500        510        520        530        540
YLKKNNQSII FENNQADLEN ATEVLSGYLE RDISQDSLQD IKQKVQDKYR YCESRRRVLL
       550
QHVHEGYEKD LWEYIED

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Y4X5-1-unknown	MDSDEG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y4X5-160-unknown	ECHVIN...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6946
Q9Y4X5-517-unknown	SLQDIK...	517	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13644

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKLFAE	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6946
...CGRQFC	303	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454774
...DISQDS	516	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13644
...EYIED	557	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	159	LFAE.\|.ECHV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	516	SQDS.\|.SLQD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)