O60763: General vesicular transport factor p115

General Information

Protein names	- General vesicular transport factor p115 - Protein USO1 homolog - Transcytosis-associated protein - TAP - Vesicle-docking protein
Gene names	USO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60763

9 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNFLRGVMGG QSAGPQHTEA ETIQKLCDRV ASSTLLDDRR NAVRALKSLS KKYRLEVGIQ
        70         80         90        100        110        120
AMEHLIHVLQ TDRSDSEIIG YALDTLYNII SNEEEEEVEE NSTRQSEDLG SQFTEIFIKQ
       130        140        150        160        170        180
QENVTLLLSL LEEFDFHVRW PGVKLLTSLL KQLGPQVQQI ILVSPMGVSR LMDLLADSRE
       190        200        210        220        230        240
VIRNDGVLLL QALTRSNGAI QKIVAFENAF ERLLDIISEE GNSDGGIVVE DCLILLQNLL
       250        260        270        280        290        300
KNNNSNQNFF KEGSYIQRMK PWFEVGDENS GWSAQKVTNL HLMLQLVRVL VSPTNPPGAT
       310        320        330        340        350        360
SSCQKAMFQC GLLQQLCTIL MATGVPADIL TETINTVSEV IRGCQVNQDY FASVNAPSNP
       370        380        390        400        410        420
PRPAIVVLLM SMVNERQPFV LRCAVLYCFQ CFLYKNQKGQ GEIVSTLLPS TIDATGNSVS
       430        440        450        460        470        480
AGQLLCGGLF STDSLSNWCA AVALAHALQE NATQKEQLLR VQLATSIGNP PVSLLQQCTN
       490        500        510        520        530        540
ILSQGSKIQT RVGLLMLLCT WLSNCPIAVT HFLHNSANVP FLTGQIAENL GEEEQLVQGL
       550        560        570        580        590        600
CALLLGISIY FNDNSLESYM KEKLKQLIEK RIGKENFIEK LGFISKHELY SRASQKPQPN
       610        620        630        640        650        660
FPSPEYMIFD HEFTKLVKEL EGVITKAIYK SSEEDKKEEE VKKTLEQHDN IVTHYKNMIR
       670        680        690        700        710        720
EQDLQLEELR QQVSTLKCQN EQLQTAVTQQ VSQIQQHKDQ YNLLKIQLGK DNQHQGSYSE
       730        740        750        760        770        780
GAQMNGIQPE EIGRLREEIE ELKRNQELLQ SQLTEKDSMI ENMKSSQTSG TNEQSSAIVS
       790        800        810        820        830        840
ARDSEQVAEL KQELATLKSQ LNSQSVEITK LQTEKQELLQ KTEAFAKSVE VQGETETIIA
       850        860        870        880        890        900
TKTTDVEGRL SALLQETKEL KNEIKALSEE RTAIKEQLDS SNSTIAILQT EKDKLELEIT
       910        920        930        940        950        960
DSKKEQDDLL VLLADQDQKI LSLKNKLKDL GHPVEEEDEL ESGDQEDEDD ESEDPGKDLD

HI

Isoforms

- Isoform 2 of General vesicular transport factor p115

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60763-1-unknown	MNFLRG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60763-1-unknown	MNFLRG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93995
O60763-6-	GVMGGQ...	6		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60763-6-unknown	GVMGGQ...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178277
O60763-9-unknown	GGQSAG...	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5208
O60763-9-unknown	GGQSAG...	9		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O60763-9-unknown	GGQSAG...	9	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160379
O60763-9-	GGQSAG...	9		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O60763-726-unknown	GIQPEE...	726	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171863
O60763-726-	GIQPEE...	726		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60763-758-	SMIENM...	758		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O60763-758-unknown	SMIENM...	758	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3000
O60763-758-unknown	SMIENM...	758	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1472
O60763-758-unknown	SMIENM...	758		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O60763-758-unknown	SMIENM...	758	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156354

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRGVMG	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5208
...TEAETI	22	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000474837
...TEAETI	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108287
...LTEKDS	757	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3000
...LTEKDS	757	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1472
...LTEKDS	757	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139832
...DLDHI	962	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DLDHI	962	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89613

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	8	GVMG.\|.GGQS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP8_HUMAN	757	EKDS.\|.SMIE	inferred from experiment	unknown	MEROPS	Shields D	Chiu R et al.:A caspase cleavage fragment of ... (C14.003)	12438416,
CASP3_HUMAN	757	EKDS.\|.SMIE	inferred from experiment	unknown	MEROPS	Shields D	Chiu R et al.:A caspase cleavage fragment of ... (C14.003)	12438416,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)