Q9UPU5: Ubiquitin carboxyl-terminal hydrolase 24

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 24 - 3.4.19.12 - Deubiquitinating enzyme 24 - Ubiquitin thioesterase 24 - Ubiquitin-specific-processing protease 24
Gene names	USP24
Organism	Homo sapiens
Protease Family
Protease ID	C19.047
Chromosome location
UniProt ID	Q9UPU5

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY GGYEPMDSGG
        70         80         90        100        110        120
GPSPGPGGGP RGDGGGDGGG GGPSRGGSTG GGGGFDPPPA YHEVVDAEKN DENGNCSGEG
       130        140        150        160        170        180
IEFPTTNLYE LESRVLTDHW SIPYKREESL GKCLLASTYL ARLGLSESDE NCRRFMDRCM
       190        200        210        220        230        240
PEAFKKLLTS SAVHKWGTEI HEGIYNMLML LIELVAERIK QDPIPTGLLG VLTMAFNPDN
       250        260        270        280        290        300
EYHFKNRMKV SQRNWAEVFG EGNMFAVSPV STFQKEPHGW VVDLVNKFGE LGGFAAIQAK
       310        320        330        340        350        360
LHSEDIELGA VSALIQPLGV CAEYLNSSVV QPMLDPVILT TIQDVRSVEE KDLKDKRLVS
       370        380        390        400        410        420
IPELLSAVKL LCMRFQPDLV TIVDDLRLDI LLRMLKSPHF SAKMNSLKEV TKLIEDSTLS
       430        440        450        460        470        480
KSVKNAIDTD RLLDWLVENS VLSIALEGNI DQAQYCDRIK GIIELLGSKL SLDELTKIWK
       490        500        510        520        530        540
IQSGQSSTVI ENIHTIIAAA AVKFNSDQLN HLFVLIQKSW ETESDRVRQK LLSLIGRIGR
       550        560        570        580        590        600
EARFETTSGK VLDVLWELAH LPTLPSSLIQ QALEEHLTIL SDAYAVKEAI KRSYIIKCIE
       610        620        630        640        650        660
DIKRPGEWSG LEKNKKDGFK SSQLNNPQFV WVVPALRQLH EITRSFIKQT YQKQDKSIIQ
       670        680        690        700        710        720
DLKKNFEIVK LVTGSLIACH RLAAAVAGPG GLSGSTLVDG RYTYREYLEA HLKFLAFFLQ
       730        740        750        760        770        780
EATLYLGWNR AKEIWECLVT GQDVCELDRE MCFEWFTKGQ HDLESDVQQQ LFKEKILKLE
       790        800        810        820        830        840
SYEITMNGFN LFKTFFENVN LCDHRLKRQG AQLYVEKLEL IGMDFIWKIA MESPDEEIAN
       850        860        870        880        890        900
EAIQLIINYS YINLNPRLKK DSVSLHKKFI ADCYTRLEAA SSALGGPTLT HAVTRATKML
       910        920        930        940        950        960
TATAMPTVAT SVQSPYRSTK LVIIERLLLL AERYVITIED FYSVPRTILP HGASFHGHLL
       970        980        990       1000       1010       1020
TLNVTYESTK DTFTVEAHSN ETIGSVRWKI AKQLCSPVDN IQIFTNDSLL TVNKDQKLLH
      1030       1040       1050       1060       1070       1080
QLGFSDEQIL TVKTSGSGTP SGSSADSSTS SSSSSSGVFS SSYAMEQEKS LPGVVMALVC
      1090       1100       1110       1120       1130       1140
NVFDMLYQLA NLEEPRITLR VRKLLLLIPT DPAIQEALDQ LDSLGRKKTL LSESSSQSSK
      1150       1160       1170       1180       1190       1200
SPSLSSKQQH QPSASSILES LFRSFAPGMS TFRVLYNLEV LSSKLMPTAD DDMARSCAKS
      1210       1220       1230       1240       1250       1260
FCENFLKAGG LSLVVNVMQR DSIPSEVDYE TRQGVYSICL QLARFLLVGQ TMPTLLDEDL
      1270       1280       1290       1300       1310       1320
TKDGIEALSS RPFRNVSRQT SRQMSLCGTP EKSSYRQLSV SDRSSIRVEE IIPAARVAIQ
      1330       1340       1350       1360       1370       1380
TMEVSDFTST VACFMRLSWA AAAGRLDLVG SSQPIKESNS LCPAGIRNRL SSSGSNCSSG
      1390       1400       1410       1420       1430       1440
SEGEPVALHA GICVRQQSVS TKDSLIAGEA LSLLVTCLQL RSQQLASFYN LPCVADFIID
      1450       1460       1470       1480       1490       1500
ILLGSPSAEI RRVACDQLYT LSQTDTSAHP DVQKPNQFLL GVILTAQLPL WSPTSIMRGV
      1510       1520       1530       1540       1550       1560
NQRLLSQCME YFDLRCQLLD DLTTSEMEQL RISPATMLED EITWLDNFEP NRTAECETSE
      1570       1580       1590       1600       1610       1620
ADNILLAGHL RLIKTLLSLC GAEKEMLGSS LIKPLLDDFL FRASRIILNS HSPAGSAAIS
      1630       1640       1650       1660       1670       1680
QQDFHPKCST ANSRLAAYEV LVMLADSSPS NLQIIIKELL SMHHQPDPAL TKEFDYLPPV
      1690       1700       1710       1720       1730       1740
DSRSSSGFVG LRNGGATCYM NAVFQQLYMQ PGLPESLLSV DDDTDNPDDS VFYQVQSLFG
      1750       1760       1770       1780       1790       1800
HLMESKLQYY VPENFWKIFK MWNKELYVRE QQDAYEFFTS LIDQMDEYLK KMGRDQIFKN
      1810       1820       1830       1840       1850       1860
TFQGIYSDQK ICKDCPHRYE REEAFMALNL GVTSCQSLEI SLDQFVRGEV LEGSNAYYCE
      1870       1880       1890       1900       1910       1920
KCKEKRITVK RTCIKSLPSV LVIHLMRFGF DWESGRSIKY DEQIRFPWML NMEPYTVSGM
      1930       1940       1950       1960       1970       1980
ARQDSSSEVG ENGRSVDQGG GGSPRKKVAL TENYELVGVI VHSGQAHAGH YYSFIKDRRG
      1990       2000       2010       2020       2030       2040
CGKGKWYKFN DTVIEEFDLN DETLEYECFG GEYRPKVYDQ TNPYTDVRRR YWNAYMLFYQ
      2050       2060       2070       2080       2090       2100
RVSDQNSPVL PKKSRVSVVR QEAEDLSLSA PSSPEISPQS SPRPHRPNND RLSILTKLVK
      2110       2120       2130       2140       2150       2160
KGEKKGLFVE KMPARIYQMV RDENLKFMKN RDVYSSDYFS FVLSLASLNA TKLKHPYYPC
      2170       2180       2190       2200       2210       2220
MAKVSLQLAI QFLFQTYLRT KKKLRVDTEE WIATIEALLS KSFDACQWLV EYFISSEGRE
      2230       2240       2250       2260       2270       2280
LIKIFLLECN VREVRVAVAT ILEKTLDSAL FYQDKLKSLH QLLEVLLALL DKDVPENCKN
      2290       2300       2310       2320       2330       2340
CAQYFFLFNT FVQKQGIRAG DLLLRHSALR HMISFLLGAS RQNNQIRRWS SAQAREFGNL
      2350       2360       2370       2380       2390       2400
HNTVALLVLH SDVSSQRNVA PGIFKQRPPI SIAPSSPLLP LHEEVEALLF MSEGKPYLLE
      2410       2420       2430       2440       2450       2460
VMFALRELTG SLLALIEMVV YCCFCNEHFS FTMLHFIKNQ LETAPPHELK NTFQLLHEIL
      2470       2480       2490       2500       2510       2520
VIEDPIQVER VKFVFETENG LLALMHHSNH VDSSRCYQCV KFLVTLAQKC PAAKEYFKEN
      2530       2540       2550       2560       2570       2580
SHHWSWAVQW LQKKMSEHYW TPQSNVSNET STGKTFQRTI SAQDTLAYAT ALLNEKEQSG
      2590       2600       2610       2620
SSNGSESSPA NENGDRHLQQ GSESPMMIGE LRSDLDDVDP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UPU5-1-unknown	MESEEE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UPU5-9-unknown	MTTLLC...	9	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000385700
Q9UPU5-1610-unknown	SHSPAG...	1610	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6872
Q9UPU5-1616-unknown	SAAISQ...	1616	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4298

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RIILNS	1609	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6872
...HSPAGS	1615	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4298
...DDVDP	2620	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	1609	ILNS.\|.SHSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	1615	PAGS.\|.SAAI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)