Q96HC4: PDZ and LIM domain protein 5

General Information

Protein names	- PDZ and LIM domain protein 5 - Enigma homolog - Enigma-like PDZ and LIM domains protein
Gene names	PDLIM5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96HC4

14 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of PDZ and LIM domain protein 5 - Isoform 3 of PDZ and LIM domain protein 5 - Isoform 4 of PDZ and LIM domain protein 5 - Isoform 5 of PDZ and LIM domain protein 5 - Isoform 6 of PDZ and LIM domain protein 5 - Isoform 7 of PDZ and LIM domain protein 5

Sequence View

        10         20         30         40         50         60
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG
        70         80         90        100        110        120
MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST
       130        140        150        160        170        180
NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH
       190        200        210        220        230        240
ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR
       250        260        270        280        290        300
KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
       310        320        330        340        350        360
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS
       370        380        390        400        410        420
PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC
       430        440        450        460        470        480
AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG
       490        500        510        520        530        540
RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG
       550        560        570        580        590
CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF         10         20         30         40         50         60
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG
        70         80         90        100        110        120
MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST
       130        140        150        160        170        180
NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH
       190        200        210        220        230        240
ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR
       250        260        270        280        290        300
KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
       310        320        330        340        350        360
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS
       370        380        390        400        410        420
PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC
       430        440        450        460        470        480
AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG
       490        500        510        520        530        540
RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG
       550        560        570        580        590
CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF         10         20         30         40         50         60
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG
        70         80         90        100        110        120
MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST
       130        140        150        160        170        180
NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH
       190        200        210        220        230        240
ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR
       250        260        270        280        290        300
KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
       310        320        330        340        350        360
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS
       370        380        390        400        410        420
PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC
       430        440        450        460        470        480
AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG
       490        500        510        520        530        540
RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG
       550        560        570        580        590
CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF         10         20         30         40         50         60
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG
        70         80         90        100        110        120
MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST
       130        140        150        160        170        180
NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH
       190        200        210        220        230        240
ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR
       250        260        270        280        290        300
KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
       310        320        330        340        350        360
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS
       370        380        390        400        410        420
PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC
       430        440        450        460        470        480
AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG
       490        500        510        520        530        540
RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG
       550        560        570        580        590
CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF         10         20         30         40         50         60
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG
        70         80         90        100        110        120
MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST
       130        140        150        160        170        180
NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH
       190        200        210        220        230        240
ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR
       250        260        270        280        290        300
KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
       310        320        330        340        350        360
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS
       370        380        390        400        410        420
PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC
       430        440        450        460        470        480
AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG
       490        500        510        520        530        540
RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG
       550        560        570        580        590
CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF         10         20         30         40         50         60
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG
        70         80         90        100        110        120
MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST
       130        140        150        160        170        180
NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH
       190        200        210        220        230        240
ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR
       250        260        270        280        290        300
KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
       310        320        330        340        350        360
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS
       370        380        390        400        410        420
PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC
       430        440        450        460        470        480
AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG
       490        500        510        520        530        540
RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG
       550        560        570        580        590
CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96HC4-1-unknown	MSNYSV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84756
Q96HC4-1-unknown	MSNYSV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84757
Q96HC4-1-unknown	MSNYSV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84758
Q96HC4-1-unknown	MSNYSV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84759
Q96HC4-1-unknown	MSNYSV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84760
Q96HC4-1-unknown	MSNYSV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84761
Q96HC4-2-unknown	MSNYSV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110825
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110826
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110827
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110828
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110829
Q96HC4-2-Acetylation	SNYSVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110830
Q96HC4-123-unknown	MAYNKA...	123		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442187
Q96HC4-175-	AASGLH...	175			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96HC4-175-	AASGLH...	175			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96HC4-189-unknown	QSPSAL...	189		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13068
Q96HC4-195-unknown	SAGKTA...	195		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14836
Q96HC4-216-unknown	TSQELA...	216		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13069
Q96HC4-216-unknown	TSQELA...	216		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198192
Q96HC4-216-unknown	TSQELA...	216		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198193
Q96HC4-216-unknown	TSQELA...	216		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198194
Q96HC4-216-unknown	TSQELA...	216		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198195
Q96HC4-289-unknown	ITGTEH...	289		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4193
Q96HC4-289-unknown	ITGTEH...	289		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145895
Q96HC4-289-unknown	ITGTEH...	289		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146103
Q96HC4-365-unknown	RPNQGV...	365		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6677
Q96HC4-365-unknown	RPNQGV...	365		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148671
Q96HC4-365-unknown	RPNQGV...	365		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148883
Q96HC4-365-unknown	RPNQGV...	365		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151899
Q96HC4-385-unknown	SVAPAN...	385		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177790
Q96HC4-385-unknown	SVAPAN...	385		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177788
Q96HC4-385-unknown	SVAPAN...	385		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177789
Q96HC4-385-	SVAPAN...	385			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96HC4-391-unknown	SALGQT...	391		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177794
Q96HC4-391-unknown	SALGQT...	391		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177792
Q96HC4-391-unknown	SALGQT...	391		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177793
Q96HC4-391-	SALGQT...	391			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NLSADQ	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13068
...SPSALS	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14836
...SVCSET	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13069
...RILAQI	288	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4193
...RILAQI	288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128661
...RILAQI	288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129191
...RILAQI	288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129403
...RILAQI	288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129404
...RILAQI	288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129405
...SPSWQR	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6677
...SPSWQR	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132046
...SPSWQR	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132261
...SPSWQR	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135307
...KDKPLC	586	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80379
...KDKPLC	586	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424297
...KDKPLC	586	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92905
...KDKPLC	586	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92904
...HSVNF	596	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HSVNF	596	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80376
...HSVNF	596	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80378

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	188	SADQ.\|.QSPS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	194	SALS.\|.SAGK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	215	CSET.\|.TSQE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	288	LAQI.\|.ITGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	364	SWQR.\|.RPNQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)