P06730: Eukaryotic translation initiation factor 4E

General Information

Protein names	- Eukaryotic translation initiation factor 4E - eIF-4E - eIF4E - eIF-4F 25 kDa subunit - mRNA cap-binding protein
Gene names	EIF4E
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06730

7 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 4E - Isoform 3 of Eukaryotic translation initiation factor 4E

Sequence View

        10         20         30         40         50         60
MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL
        70         80         90        100        110        120
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ
       130        140        150        160        170        180
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG
       190        200        210
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV         10         20         30         40         50         60
MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL
        70         80         90        100        110        120
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ
       130        140        150        160        170        180
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG
       190        200        210
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06730-1-unknown	MATVEP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77547
P06730-2-unknown	MATVEP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06730-2-Acetylation	ATVEPE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06730-2-Acetylation	ATVEPE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111452
P06730-187-	LGLPPK...	187			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P06730-187-	LGLPPK...	187			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P06730-187-unknown	LGLPPK...	187		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165762
P06730-187-unknown	LGLPPK...	187		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165763
P06730-196-unknown	GYQSHA...	196		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5410
P06730-196-unknown	GYQSHA...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147193
P06730-196-unknown	GYQSHA...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147616
P06730-197-unknown	YQSHAD...	197		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3494
P06730-197-unknown	YQSHAD...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147244
P06730-197-unknown	YQSHAD...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147671

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PKIVIG	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5410
...PKIVIG	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130533
...PKIVIG	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130968
...KIVIGY	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3494
...KIVIGY	196	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130587
...KIVIGY	196	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131024
...NRFVV	217	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NRFVV	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73166
...NRFVV	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73165

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	195	IVIG.\|.GYQS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	196	VIGY.\|.YQSH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)