Q13564: NEDD8-activating enzyme E1 regulatory subunit
Protein names | - NEDD8-activating enzyme E1 regulatory subunit - Amyloid beta precursor protein-binding protein 1, 59 kDa - APP-BP1 - Amyloid protein-binding protein 1 - Proto-oncogene protein 1 |
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Gene names | NAE1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q13564 |
10
N-termini
7
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII
70 80 90 100 110 120
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF
130 140 150 160 170 180
CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL
190 200 210 220 230 240
EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK
250 260 270 280 290 300
EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ
310 320 330 340 350 360
TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH
370 380 390 400 410 420
VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD
430 440 450 460 470 480
NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH
490 500 510 520 530
EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL
Isoforms
- Isoform 2 of NEDD8-activating enzyme E1 regulatory subunit - Isoform 3 of NEDD8-activating enzyme E1 regulatory subunit - Isoform 4 of NEDD8-activating enzyme E1 regulatory subunitSequence View
10 20 30 40 50 60
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII
70 80 90 100 110 120
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF
130 140 150 160 170 180
CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL
190 200 210 220 230 240
EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK
250 260 270 280 290 300
EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ
310 320 330 340 350 360
TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH
370 380 390 400 410 420
VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD
430 440 450 460 470 480
NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH
490 500 510 520 530
EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL
10 20 30 40 50 60
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII
70 80 90 100 110 120
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF
130 140 150 160 170 180
CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL
190 200 210 220 230 240
EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK
250 260 270 280 290 300
EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ
310 320 330 340 350 360
TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH
370 380 390 400 410 420
VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD
430 440 450 460 470 480
NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH
490 500 510 520 530
EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL
10 20 30 40 50 60
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII
70 80 90 100 110 120
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF
130 140 150 160 170 180
CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL
190 200 210 220 230 240
EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK
250 260 270 280 290 300
EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ
310 320 330 340 350 360
TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH
370 380 390 400 410 420
VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD
430 440 450 460 470 480
NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH
490 500 510 520 530
EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL
Protein Neighborhood
Domains & Features
10 N-termini - 7 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q13564-1-unknown | MAQLGK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt93873 | |||
Q13564-2-unknown | MAQLGK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q13564-2-Acetylation | AQLGKL... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q13564-2-Acetylation | AQLGKL... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q13564-2-Acetylation | AQLGKL... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q13564-2-Acetylation | AQLGKL... | 2 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
Q13564-2-Acetylation | AQLGKL... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110845 | ||
Q13564-90-unknown | MEFLQE... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt93872 | |||
Q13564-90-unknown | MEFLQE... | 90 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000377637 | |||
Q13564-90-unknown | MEFLQE... | 90 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000464119 | |||
Q13564-90-unknown | MEFLQE... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105745 | |||
Q13564-90-unknown | MEFLQE... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105744 | |||
Q13564-174-unknown | SHPDNA... | 174 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7785 | |||
Q13564-174-unknown | SHPDNA... | 174 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6347 | |||
Q13564-174-unknown | SHPDNA... | 174 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141564 | |||
Q13564-174-unknown | SHPDNA... | 174 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145451 | |||
Q13564-174-unknown | SHPDNA... | 174 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145793 | |||
Q13564-367-unknown | SIGQAP... | 367 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176375 | |||
Q13564-367-unknown | SIGQAP... | 367 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176376 | |||
Q13564-367-unknown | SIGQAP... | 367 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176374 | |||
Q13564-367- | SIGQAP... | 367 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q13564-367- | SIGQAP... | 367 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q13564-367- | SIGQAP... | 367 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q13564-370-unknown | QAPESI... | 370 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000462937 | |||
Q13564-370-unknown | QAPESI... | 370 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt199205 | |||
Q13564-370-unknown | QAPESI... | 370 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt199206 | |||
Q13564-370-unknown | QAPESI... | 370 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt199204 | |||
Q13564-435-unknown | FHKQQG... | 435 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000463546 | |||
Q13564-435-unknown | FHKQQG... | 435 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt199483 | |||
Q13564-435-unknown | FHKQQG... | 435 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt199484 | |||
Q13564-435-unknown | FHKQQG... | 435 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt199482 | |||
Q13564-496-unknown | FLGGAA... | 496 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3992 | |||
Q13564-496-unknown | FLGGAA... | 496 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152112 | |||
Q13564-496-unknown | FLGGAA... | 496 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153306 | |||
Q13564-496-unknown | FLGGAA... | 496 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153397 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ATQLPE | 132 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000455967 | |||
...ATQLPE | 132 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt154744 | |||
...ATQLPE | 132 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt154745 | |||
...ATQLPE | 132 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt154743 | |||
...IIIKEH | 168 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000462040 | |||
...IIIKEH | 168 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155249 | |||
...IIIKEH | 168 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155250 | |||
...IIIKEH | 168 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155248 | |||
...HPVIES | 173 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7785 | |||
...HPVIES | 173 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6347 | |||
...HPVIES | 173 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124741 | |||
...HPVIES | 173 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128746 | |||
...HPVIES | 173 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129090 | |||
...HSHTPW | 213 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000464119 | |||
...HSHTPW | 213 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155755 | |||
...HSHTPW | 213 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155756 | |||
...HSHTPW | 213 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155754 | |||
...YLAQWY | 225 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000454506 | |||
...HTIAAF | 495 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3992 | |||
...HTIAAF | 495 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135521 | |||
...HTIAAF | 495 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136730 | |||
...HTIAAF | 495 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136821 | |||
...ATFQL | 534 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...ATFQL | 534 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89490 | |||
...ATFQL | 534 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89489 | |||
...ATFQL | 534 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89491 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATS_HUMAN | 173 | VIES.|.SHPD | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATL1_HUMAN | 173 | VIES.|.SHPD | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATB_HUMAN | 495 | IAAF.|.FLGG | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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