P67775: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

General Information

Protein names	- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform - PP2A-alpha - 3.1.3.16 {ECO:0000269\|PubMed:1848668, ECO:0000269\|PubMed:30611118} - Replication protein C - RP-C
Gene names	PPP2CA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P67775

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG
        70         80         90        100        110        120
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES
       130        140        150        160        170        180
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI
       190        200        210        220        230        240
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA
       250        260        270        280        290        300
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV

TRRTPDYFL

Isoforms

- Isoform 2 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P67775-1-unknown	MDEKVF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P67775-1-unknown	MDEKVF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85849
P67775-1-acetylation	MDEKVF...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P67775-1-acetylation	MDEKVF...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182865
P67775-168-unknown	GGLSPS...	168		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7665
P67775-168-unknown	GGLSPS...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145473
P67775-169-unknown	GLSPSI...	169		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6149
P67775-169-unknown	GLSPSI...	169		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145475

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IFCLHG	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7665
...IFCLHG	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128769
...FCLHGG	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6149
...FCLHGG	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128771
...PDYFL methylation-	309	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PDYFL methylation-	309	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92334
...PDYFL	309	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81467

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	167	CLHG.\|.GGLS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	168	LHGG.\|.GLSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)