Q15154: Pericentriolar material 1 protein

General Information

Protein names	- Pericentriolar material 1 protein - PCM-1 - hPCM-1
Gene names	PCM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15154

18 N-termini

7 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pericentriolar material 1 protein - Isoform 3 of Pericentriolar material 1 protein - Isoform 2 of Pericentriolar material 1 protein - Isoform 3 of Pericentriolar material 1 protein - Isoform 4 of Pericentriolar material 1 protein - Isoform 5 of Pericentriolar material 1 protein

Sequence View

        10         20         30         40         50         60
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV
        70         80         90        100        110        120
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD
       130        140        150        160        170        180
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTNP PNRETIGSAQ CKELFASALS
       190        200        210        220        230        240
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT
       250        260        270        280        290        300
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ
       310        320        330        340        350        360
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA
       370        380        390        400        410        420
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQKM DKLLGELHTL
       430        440        450        460        470        480
RDQHLNNSSA SPQRSVDQRS TSAPSASVGL APVVNGESNS LTSSVPYPTA SLVSQNESEN
       490        500        510        520        530        540
EGHLNPSEKL QKLNEVRKRL NELRELVHYY EQTSDMMTDA VNENRKDEET EESEYDSEHE
       550        560        570        580        590        600
NSEPVTNIRN PQVASTWNEV NSHSNAQCVS NNRDGRTVNS NCEINNRSAA NIRALNMPPS
       610        620        630        640        650        660
LDCRYNREGE QEIHVAQGED DEEEEEEAEE EGVSGASLSS HRSSLVDEHP EDAEFEQKIN
       670        680        690        700        710        720
RLMAAKQKLR QLQDLVAMVQ DDDAAQGVIS ASASNLDDFY PAEEDTKQNS NNTRGNANKT
       730        740        750        760        770        780
QKDTGVNEKA REKFYEAKLQ QQQRELKQLQ EERKKLIDIQ EKIQALQTAC PDLQLSAASV
       790        800        810        820        830        840
GNCPTKKYMP AVTSTPTVNQ HETSTSKSVF EPEDSSIVDN ELWSEMRRHE MLREELRQRR
       850        860        870        880        890        900
KQLEALMAEH QRRQGLAETA SPVAVSLRSD GSENLCTPQQ SRTEKTMATW GGSTQCALDE
       910        920        930        940        950        960
EGDEDGYLSE GIVRTDEEEE EEQDASSNDN FSVCPSNSVN HNSYNGKETK NRWKNNCPFS
       970        980        990       1000       1010       1020
ADENYRPLAK TRQQNISMQR QENLRWVSEL SYVEEKEQWQ EQINQLKKQL DFSVSICQTL
      1030       1040       1050       1060       1070       1080
MQDQQTLSCL LQTLLTGPYS VMPSNVASPQ VHFIMHQLNQ CYTQLTWQQN NVQRLKQMLN
      1090       1100       1110       1120       1130       1140
ELMRQQNQHP EKPGGKERGS SASHPPSPSL FCPFSFPTQP VNLFNIPGFT NFSSFAPGMN
      1150       1160       1170       1180       1190       1200
FSPLFPSNFG DFSQNISTPS EQQQPLAQNS SGKTEYMAFP KPFESSSSIG AEKPRNKKLP
      1210       1220       1230       1240       1250       1260
EEEVESSRTP WLYEQEGEVE KPFIKTGFSV SVEKSTSSNR KNQLDTNGRR RQFDEESLES
      1270       1280       1290       1300       1310       1320
FSSMPDPVDP TTVTKTFKTR KASAQASLAS KDKTPKSKSK KRNSTQLKSR VKNIRYESAS
      1330       1340       1350       1360       1370       1380
MSSTCEPCKS RNRHSAQTEE PVQAKVFSRK NHEQLEKIIK CNRSTEISSE TGSDFSMFEA
      1390       1400       1410       1420       1430       1440
LRDTIYSEVA TLISQNESRP HFLIELFHEL QLLNTDYLRQ RALYALQDIV SRHISESHEK
      1450       1460       1470       1480       1490       1500
GENVKSVNSG TWIASNSELT PSESLATTDD ETFEKNFERE THKISEQNDA DNASVLSVSS
      1510       1520       1530       1540       1550       1560
NFEPFATDDL GNTVIHLDQA LARMREYERM KTEAESNSNM RCTCRIIEDG DGAGAGTTVN
      1570       1580       1590       1600       1610       1620
NLEETPVIEN RSSQQPVSEV STIPCPRIDT QQLDRQIKAI MKEVIPFLKE HMDEVCSSQL
      1630       1640       1650       1660       1670       1680
LTSVRRMVLT LTQQNDESKE FVKFFHKQLG SILQDSLAKF AGRKLKDCGE DLLVEISEVL
      1690       1700       1710       1720       1730       1740
FNELAFFKLM QDLDNNSITV KQRCKRKIEA TGVIQSCAKE AKRILEDHGS PAGEIDDEDK
      1750       1760       1770       1780       1790       1800
DKDETETVKQ TQTSEVYDGP KNVRSDISDQ EEDEESEGCP VSINLSKAET QALTNYGSGE
      1810       1820       1830       1840       1850       1860
DENEDEEMEE FEEGPVDVQT SLQANTEATE ENEHDEQVLQ RDFKKTAESK NVPLEREATS
      1870       1880       1890       1900       1910       1920
KNDQNNCPVK PCYLNILEDE QPLNSAAHKE SPPTVDSTQQ PNPLPLRLPE MEPLVPRVKE
      1930       1940       1950       1960       1970       1980
VKSAQETPES SLAGSPDTES PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTIYSEAD
      1990       2000       2010       2020
LRKKMVEEEQ KNHLSGEICE MQTEELAGNS ETLKEPETVG AQSI         10         20         30         40         50         60
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV
        70         80         90        100        110        120
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD
       130        140        150        160        170        180
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTNP PNRETIGSAQ CKELFASALS
       190        200        210        220        230        240
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT
       250        260        270        280        290        300
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ
       310        320        330        340        350        360
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA
       370        380        390        400        410        420
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQKM DKLLGELHTL
       430        440        450        460        470        480
RDQHLNNSSA SPQRSVDQRS TSAPSASVGL APVVNGESNS LTSSVPYPTA SLVSQNESEN
       490        500        510        520        530        540
EGHLNPSEKL QKLNEVRKRL NELRELVHYY EQTSDMMTDA VNENRKDEET EESEYDSEHE
       550        560        570        580        590        600
NSEPVTNIRN PQVASTWNEV NSHSNAQCVS NNRDGRTVNS NCEINNRSAA NIRALNMPPS
       610        620        630        640        650        660
LDCRYNREGE QEIHVAQGED DEEEEEEAEE EGVSGASLSS HRSSLVDEHP EDAEFEQKIN
       670        680        690        700        710        720
RLMAAKQKLR QLQDLVAMVQ DDDAAQGVIS ASASNLDDFY PAEEDTKQNS NNTRGNANKT
       730        740        750        760        770        780
QKDTGVNEKA REKFYEAKLQ QQQRELKQLQ EERKKLIDIQ EKIQALQTAC PDLQLSAASV
       790        800        810        820        830        840
GNCPTKKYMP AVTSTPTVNQ HETSTSKSVF EPEDSSIVDN ELWSEMRRHE MLREELRQRR
       850        860        870        880        890        900
KQLEALMAEH QRRQGLAETA SPVAVSLRSD GSENLCTPQQ SRTEKTMATW GGSTQCALDE
       910        920        930        940        950        960
EGDEDGYLSE GIVRTDEEEE EEQDASSNDN FSVCPSNSVN HNSYNGKETK NRWKNNCPFS
       970        980        990       1000       1010       1020
ADENYRPLAK TRQQNISMQR QENLRWVSEL SYVEEKEQWQ EQINQLKKQL DFSVSICQTL
      1030       1040       1050       1060       1070       1080
MQDQQTLSCL LQTLLTGPYS VMPSNVASPQ VHFIMHQLNQ CYTQLTWQQN NVQRLKQMLN
      1090       1100       1110       1120       1130       1140
ELMRQQNQHP EKPGGKERGS SASHPPSPSL FCPFSFPTQP VNLFNIPGFT NFSSFAPGMN
      1150       1160       1170       1180       1190       1200
FSPLFPSNFG DFSQNISTPS EQQQPLAQNS SGKTEYMAFP KPFESSSSIG AEKPRNKKLP
      1210       1220       1230       1240       1250       1260
EEEVESSRTP WLYEQEGEVE KPFIKTGFSV SVEKSTSSNR KNQLDTNGRR RQFDEESLES
      1270       1280       1290       1300       1310       1320
FSSMPDPVDP TTVTKTFKTR KASAQASLAS KDKTPKSKSK KRNSTQLKSR VKNIRYESAS
      1330       1340       1350       1360       1370       1380
MSSTCEPCKS RNRHSAQTEE PVQAKVFSRK NHEQLEKIIK CNRSTEISSE TGSDFSMFEA
      1390       1400       1410       1420       1430       1440
LRDTIYSEVA TLISQNESRP HFLIELFHEL QLLNTDYLRQ RALYALQDIV SRHISESHEK
      1450       1460       1470       1480       1490       1500
GENVKSVNSG TWIASNSELT PSESLATTDD ETFEKNFERE THKISEQNDA DNASVLSVSS
      1510       1520       1530       1540       1550       1560
NFEPFATDDL GNTVIHLDQA LARMREYERM KTEAESNSNM RCTCRIIEDG DGAGAGTTVN
      1570       1580       1590       1600       1610       1620
NLEETPVIEN RSSQQPVSEV STIPCPRIDT QQLDRQIKAI MKEVIPFLKE HMDEVCSSQL
      1630       1640       1650       1660       1670       1680
LTSVRRMVLT LTQQNDESKE FVKFFHKQLG SILQDSLAKF AGRKLKDCGE DLLVEISEVL
      1690       1700       1710       1720       1730       1740
FNELAFFKLM QDLDNNSITV KQRCKRKIEA TGVIQSCAKE AKRILEDHGS PAGEIDDEDK
      1750       1760       1770       1780       1790       1800
DKDETETVKQ TQTSEVYDGP KNVRSDISDQ EEDEESEGCP VSINLSKAET QALTNYGSGE
      1810       1820       1830       1840       1850       1860
DENEDEEMEE FEEGPVDVQT SLQANTEATE ENEHDEQVLQ RDFKKTAESK NVPLEREATS
      1870       1880       1890       1900       1910       1920
KNDQNNCPVK PCYLNILEDE QPLNSAAHKE SPPTVDSTQQ PNPLPLRLPE MEPLVPRVKE
      1930       1940       1950       1960       1970       1980
VKSAQETPES SLAGSPDTES PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTIYSEAD
      1990       2000       2010       2020
LRKKMVEEEQ KNHLSGEICE MQTEELAGNS ETLKEPETVG AQSI         10         20         30         40         50         60
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV
        70         80         90        100        110        120
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD
       130        140        150        160        170        180
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTNP PNRETIGSAQ CKELFASALS
       190        200        210        220        230        240
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT
       250        260        270        280        290        300
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ
       310        320        330        340        350        360
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA
       370        380        390        400        410        420
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQKM DKLLGELHTL
       430        440        450        460        470        480
RDQHLNNSSA SPQRSVDQRS TSAPSASVGL APVVNGESNS LTSSVPYPTA SLVSQNESEN
       490        500        510        520        530        540
EGHLNPSEKL QKLNEVRKRL NELRELVHYY EQTSDMMTDA VNENRKDEET EESEYDSEHE
       550        560        570        580        590        600
NSEPVTNIRN PQVASTWNEV NSHSNAQCVS NNRDGRTVNS NCEINNRSAA NIRALNMPPS
       610        620        630        640        650        660
LDCRYNREGE QEIHVAQGED DEEEEEEAEE EGVSGASLSS HRSSLVDEHP EDAEFEQKIN
       670        680        690        700        710        720
RLMAAKQKLR QLQDLVAMVQ DDDAAQGVIS ASASNLDDFY PAEEDTKQNS NNTRGNANKT
       730        740        750        760        770        780
QKDTGVNEKA REKFYEAKLQ QQQRELKQLQ EERKKLIDIQ EKIQALQTAC PDLQLSAASV
       790        800        810        820        830        840
GNCPTKKYMP AVTSTPTVNQ HETSTSKSVF EPEDSSIVDN ELWSEMRRHE MLREELRQRR
       850        860        870        880        890        900
KQLEALMAEH QRRQGLAETA SPVAVSLRSD GSENLCTPQQ SRTEKTMATW GGSTQCALDE
       910        920        930        940        950        960
EGDEDGYLSE GIVRTDEEEE EEQDASSNDN FSVCPSNSVN HNSYNGKETK NRWKNNCPFS
       970        980        990       1000       1010       1020
ADENYRPLAK TRQQNISMQR QENLRWVSEL SYVEEKEQWQ EQINQLKKQL DFSVSICQTL
      1030       1040       1050       1060       1070       1080
MQDQQTLSCL LQTLLTGPYS VMPSNVASPQ VHFIMHQLNQ CYTQLTWQQN NVQRLKQMLN
      1090       1100       1110       1120       1130       1140
ELMRQQNQHP EKPGGKERGS SASHPPSPSL FCPFSFPTQP VNLFNIPGFT NFSSFAPGMN
      1150       1160       1170       1180       1190       1200
FSPLFPSNFG DFSQNISTPS EQQQPLAQNS SGKTEYMAFP KPFESSSSIG AEKPRNKKLP
      1210       1220       1230       1240       1250       1260
EEEVESSRTP WLYEQEGEVE KPFIKTGFSV SVEKSTSSNR KNQLDTNGRR RQFDEESLES
      1270       1280       1290       1300       1310       1320
FSSMPDPVDP TTVTKTFKTR KASAQASLAS KDKTPKSKSK KRNSTQLKSR VKNIRYESAS
      1330       1340       1350       1360       1370       1380
MSSTCEPCKS RNRHSAQTEE PVQAKVFSRK NHEQLEKIIK CNRSTEISSE TGSDFSMFEA
      1390       1400       1410       1420       1430       1440
LRDTIYSEVA TLISQNESRP HFLIELFHEL QLLNTDYLRQ RALYALQDIV SRHISESHEK
      1450       1460       1470       1480       1490       1500
GENVKSVNSG TWIASNSELT PSESLATTDD ETFEKNFERE THKISEQNDA DNASVLSVSS
      1510       1520       1530       1540       1550       1560
NFEPFATDDL GNTVIHLDQA LARMREYERM KTEAESNSNM RCTCRIIEDG DGAGAGTTVN
      1570       1580       1590       1600       1610       1620
NLEETPVIEN RSSQQPVSEV STIPCPRIDT QQLDRQIKAI MKEVIPFLKE HMDEVCSSQL
      1630       1640       1650       1660       1670       1680
LTSVRRMVLT LTQQNDESKE FVKFFHKQLG SILQDSLAKF AGRKLKDCGE DLLVEISEVL
      1690       1700       1710       1720       1730       1740
FNELAFFKLM QDLDNNSITV KQRCKRKIEA TGVIQSCAKE AKRILEDHGS PAGEIDDEDK
      1750       1760       1770       1780       1790       1800
DKDETETVKQ TQTSEVYDGP KNVRSDISDQ EEDEESEGCP VSINLSKAET QALTNYGSGE
      1810       1820       1830       1840       1850       1860
DENEDEEMEE FEEGPVDVQT SLQANTEATE ENEHDEQVLQ RDFKKTAESK NVPLEREATS
      1870       1880       1890       1900       1910       1920
KNDQNNCPVK PCYLNILEDE QPLNSAAHKE SPPTVDSTQQ PNPLPLRLPE MEPLVPRVKE
      1930       1940       1950       1960       1970       1980
VKSAQETPES SLAGSPDTES PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTIYSEAD
      1990       2000       2010       2020
LRKKMVEEEQ KNHLSGEICE MQTEELAGNS ETLKEPETVG AQSI         10         20         30         40         50         60
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV
        70         80         90        100        110        120
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD
       130        140        150        160        170        180
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTNP PNRETIGSAQ CKELFASALS
       190        200        210        220        230        240
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT
       250        260        270        280        290        300
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ
       310        320        330        340        350        360
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA
       370        380        390        400        410        420
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQKM DKLLGELHTL
       430        440        450        460        470        480
RDQHLNNSSA SPQRSVDQRS TSAPSASVGL APVVNGESNS LTSSVPYPTA SLVSQNESEN
       490        500        510        520        530        540
EGHLNPSEKL QKLNEVRKRL NELRELVHYY EQTSDMMTDA VNENRKDEET EESEYDSEHE
       550        560        570        580        590        600
NSEPVTNIRN PQVASTWNEV NSHSNAQCVS NNRDGRTVNS NCEINNRSAA NIRALNMPPS
       610        620        630        640        650        660
LDCRYNREGE QEIHVAQGED DEEEEEEAEE EGVSGASLSS HRSSLVDEHP EDAEFEQKIN
       670        680        690        700        710        720
RLMAAKQKLR QLQDLVAMVQ DDDAAQGVIS ASASNLDDFY PAEEDTKQNS NNTRGNANKT
       730        740        750        760        770        780
QKDTGVNEKA REKFYEAKLQ QQQRELKQLQ EERKKLIDIQ EKIQALQTAC PDLQLSAASV
       790        800        810        820        830        840
GNCPTKKYMP AVTSTPTVNQ HETSTSKSVF EPEDSSIVDN ELWSEMRRHE MLREELRQRR
       850        860        870        880        890        900
KQLEALMAEH QRRQGLAETA SPVAVSLRSD GSENLCTPQQ SRTEKTMATW GGSTQCALDE
       910        920        930        940        950        960
EGDEDGYLSE GIVRTDEEEE EEQDASSNDN FSVCPSNSVN HNSYNGKETK NRWKNNCPFS
       970        980        990       1000       1010       1020
ADENYRPLAK TRQQNISMQR QENLRWVSEL SYVEEKEQWQ EQINQLKKQL DFSVSICQTL
      1030       1040       1050       1060       1070       1080
MQDQQTLSCL LQTLLTGPYS VMPSNVASPQ VHFIMHQLNQ CYTQLTWQQN NVQRLKQMLN
      1090       1100       1110       1120       1130       1140
ELMRQQNQHP EKPGGKERGS SASHPPSPSL FCPFSFPTQP VNLFNIPGFT NFSSFAPGMN
      1150       1160       1170       1180       1190       1200
FSPLFPSNFG DFSQNISTPS EQQQPLAQNS SGKTEYMAFP KPFESSSSIG AEKPRNKKLP
      1210       1220       1230       1240       1250       1260
EEEVESSRTP WLYEQEGEVE KPFIKTGFSV SVEKSTSSNR KNQLDTNGRR RQFDEESLES
      1270       1280       1290       1300       1310       1320
FSSMPDPVDP TTVTKTFKTR KASAQASLAS KDKTPKSKSK KRNSTQLKSR VKNIRYESAS
      1330       1340       1350       1360       1370       1380
MSSTCEPCKS RNRHSAQTEE PVQAKVFSRK NHEQLEKIIK CNRSTEISSE TGSDFSMFEA
      1390       1400       1410       1420       1430       1440
LRDTIYSEVA TLISQNESRP HFLIELFHEL QLLNTDYLRQ RALYALQDIV SRHISESHEK
      1450       1460       1470       1480       1490       1500
GENVKSVNSG TWIASNSELT PSESLATTDD ETFEKNFERE THKISEQNDA DNASVLSVSS
      1510       1520       1530       1540       1550       1560
NFEPFATDDL GNTVIHLDQA LARMREYERM KTEAESNSNM RCTCRIIEDG DGAGAGTTVN
      1570       1580       1590       1600       1610       1620
NLEETPVIEN RSSQQPVSEV STIPCPRIDT QQLDRQIKAI MKEVIPFLKE HMDEVCSSQL
      1630       1640       1650       1660       1670       1680
LTSVRRMVLT LTQQNDESKE FVKFFHKQLG SILQDSLAKF AGRKLKDCGE DLLVEISEVL
      1690       1700       1710       1720       1730       1740
FNELAFFKLM QDLDNNSITV KQRCKRKIEA TGVIQSCAKE AKRILEDHGS PAGEIDDEDK
      1750       1760       1770       1780       1790       1800
DKDETETVKQ TQTSEVYDGP KNVRSDISDQ EEDEESEGCP VSINLSKAET QALTNYGSGE
      1810       1820       1830       1840       1850       1860
DENEDEEMEE FEEGPVDVQT SLQANTEATE ENEHDEQVLQ RDFKKTAESK NVPLEREATS
      1870       1880       1890       1900       1910       1920
KNDQNNCPVK PCYLNILEDE QPLNSAAHKE SPPTVDSTQQ PNPLPLRLPE MEPLVPRVKE
      1930       1940       1950       1960       1970       1980
VKSAQETPES SLAGSPDTES PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTIYSEAD
      1990       2000       2010       2020
LRKKMVEEEQ KNHLSGEICE MQTEELAGNS ETLKEPETVG AQSI         10         20         30         40         50         60
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV
        70         80         90        100        110        120
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD
       130        140        150        160        170        180
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTNP PNRETIGSAQ CKELFASALS
       190        200        210        220        230        240
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT
       250        260        270        280        290        300
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ
       310        320        330        340        350        360
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA
       370        380        390        400        410        420
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQKM DKLLGELHTL
       430        440        450        460        470        480
RDQHLNNSSA SPQRSVDQRS TSAPSASVGL APVVNGESNS LTSSVPYPTA SLVSQNESEN
       490        500        510        520        530        540
EGHLNPSEKL QKLNEVRKRL NELRELVHYY EQTSDMMTDA VNENRKDEET EESEYDSEHE
       550        560        570        580        590        600
NSEPVTNIRN PQVASTWNEV NSHSNAQCVS NNRDGRTVNS NCEINNRSAA NIRALNMPPS
       610        620        630        640        650        660
LDCRYNREGE QEIHVAQGED DEEEEEEAEE EGVSGASLSS HRSSLVDEHP EDAEFEQKIN
       670        680        690        700        710        720
RLMAAKQKLR QLQDLVAMVQ DDDAAQGVIS ASASNLDDFY PAEEDTKQNS NNTRGNANKT
       730        740        750        760        770        780
QKDTGVNEKA REKFYEAKLQ QQQRELKQLQ EERKKLIDIQ EKIQALQTAC PDLQLSAASV
       790        800        810        820        830        840
GNCPTKKYMP AVTSTPTVNQ HETSTSKSVF EPEDSSIVDN ELWSEMRRHE MLREELRQRR
       850        860        870        880        890        900
KQLEALMAEH QRRQGLAETA SPVAVSLRSD GSENLCTPQQ SRTEKTMATW GGSTQCALDE
       910        920        930        940        950        960
EGDEDGYLSE GIVRTDEEEE EEQDASSNDN FSVCPSNSVN HNSYNGKETK NRWKNNCPFS
       970        980        990       1000       1010       1020
ADENYRPLAK TRQQNISMQR QENLRWVSEL SYVEEKEQWQ EQINQLKKQL DFSVSICQTL
      1030       1040       1050       1060       1070       1080
MQDQQTLSCL LQTLLTGPYS VMPSNVASPQ VHFIMHQLNQ CYTQLTWQQN NVQRLKQMLN
      1090       1100       1110       1120       1130       1140
ELMRQQNQHP EKPGGKERGS SASHPPSPSL FCPFSFPTQP VNLFNIPGFT NFSSFAPGMN
      1150       1160       1170       1180       1190       1200
FSPLFPSNFG DFSQNISTPS EQQQPLAQNS SGKTEYMAFP KPFESSSSIG AEKPRNKKLP
      1210       1220       1230       1240       1250       1260
EEEVESSRTP WLYEQEGEVE KPFIKTGFSV SVEKSTSSNR KNQLDTNGRR RQFDEESLES
      1270       1280       1290       1300       1310       1320
FSSMPDPVDP TTVTKTFKTR KASAQASLAS KDKTPKSKSK KRNSTQLKSR VKNIRYESAS
      1330       1340       1350       1360       1370       1380
MSSTCEPCKS RNRHSAQTEE PVQAKVFSRK NHEQLEKIIK CNRSTEISSE TGSDFSMFEA
      1390       1400       1410       1420       1430       1440
LRDTIYSEVA TLISQNESRP HFLIELFHEL QLLNTDYLRQ RALYALQDIV SRHISESHEK
      1450       1460       1470       1480       1490       1500
GENVKSVNSG TWIASNSELT PSESLATTDD ETFEKNFERE THKISEQNDA DNASVLSVSS
      1510       1520       1530       1540       1550       1560
NFEPFATDDL GNTVIHLDQA LARMREYERM KTEAESNSNM RCTCRIIEDG DGAGAGTTVN
      1570       1580       1590       1600       1610       1620
NLEETPVIEN RSSQQPVSEV STIPCPRIDT QQLDRQIKAI MKEVIPFLKE HMDEVCSSQL
      1630       1640       1650       1660       1670       1680
LTSVRRMVLT LTQQNDESKE FVKFFHKQLG SILQDSLAKF AGRKLKDCGE DLLVEISEVL
      1690       1700       1710       1720       1730       1740
FNELAFFKLM QDLDNNSITV KQRCKRKIEA TGVIQSCAKE AKRILEDHGS PAGEIDDEDK
      1750       1760       1770       1780       1790       1800
DKDETETVKQ TQTSEVYDGP KNVRSDISDQ EEDEESEGCP VSINLSKAET QALTNYGSGE
      1810       1820       1830       1840       1850       1860
DENEDEEMEE FEEGPVDVQT SLQANTEATE ENEHDEQVLQ RDFKKTAESK NVPLEREATS
      1870       1880       1890       1900       1910       1920
KNDQNNCPVK PCYLNILEDE QPLNSAAHKE SPPTVDSTQQ PNPLPLRLPE MEPLVPRVKE
      1930       1940       1950       1960       1970       1980
VKSAQETPES SLAGSPDTES PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTIYSEAD
      1990       2000       2010       2020
LRKKMVEEEQ KNHLSGEICE MQTEELAGNS ETLKEPETVG AQSI         10         20         30         40         50         60
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV
        70         80         90        100        110        120
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD
       130        140        150        160        170        180
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTNP PNRETIGSAQ CKELFASALS
       190        200        210        220        230        240
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT
       250        260        270        280        290        300
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ
       310        320        330        340        350        360
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA
       370        380        390        400        410        420
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQKM DKLLGELHTL
       430        440        450        460        470        480
RDQHLNNSSA SPQRSVDQRS TSAPSASVGL APVVNGESNS LTSSVPYPTA SLVSQNESEN
       490        500        510        520        530        540
EGHLNPSEKL QKLNEVRKRL NELRELVHYY EQTSDMMTDA VNENRKDEET EESEYDSEHE
       550        560        570        580        590        600
NSEPVTNIRN PQVASTWNEV NSHSNAQCVS NNRDGRTVNS NCEINNRSAA NIRALNMPPS
       610        620        630        640        650        660
LDCRYNREGE QEIHVAQGED DEEEEEEAEE EGVSGASLSS HRSSLVDEHP EDAEFEQKIN
       670        680        690        700        710        720
RLMAAKQKLR QLQDLVAMVQ DDDAAQGVIS ASASNLDDFY PAEEDTKQNS NNTRGNANKT
       730        740        750        760        770        780
QKDTGVNEKA REKFYEAKLQ QQQRELKQLQ EERKKLIDIQ EKIQALQTAC PDLQLSAASV
       790        800        810        820        830        840
GNCPTKKYMP AVTSTPTVNQ HETSTSKSVF EPEDSSIVDN ELWSEMRRHE MLREELRQRR
       850        860        870        880        890        900
KQLEALMAEH QRRQGLAETA SPVAVSLRSD GSENLCTPQQ SRTEKTMATW GGSTQCALDE
       910        920        930        940        950        960
EGDEDGYLSE GIVRTDEEEE EEQDASSNDN FSVCPSNSVN HNSYNGKETK NRWKNNCPFS
       970        980        990       1000       1010       1020
ADENYRPLAK TRQQNISMQR QENLRWVSEL SYVEEKEQWQ EQINQLKKQL DFSVSICQTL
      1030       1040       1050       1060       1070       1080
MQDQQTLSCL LQTLLTGPYS VMPSNVASPQ VHFIMHQLNQ CYTQLTWQQN NVQRLKQMLN
      1090       1100       1110       1120       1130       1140
ELMRQQNQHP EKPGGKERGS SASHPPSPSL FCPFSFPTQP VNLFNIPGFT NFSSFAPGMN
      1150       1160       1170       1180       1190       1200
FSPLFPSNFG DFSQNISTPS EQQQPLAQNS SGKTEYMAFP KPFESSSSIG AEKPRNKKLP
      1210       1220       1230       1240       1250       1260
EEEVESSRTP WLYEQEGEVE KPFIKTGFSV SVEKSTSSNR KNQLDTNGRR RQFDEESLES
      1270       1280       1290       1300       1310       1320
FSSMPDPVDP TTVTKTFKTR KASAQASLAS KDKTPKSKSK KRNSTQLKSR VKNIRYESAS
      1330       1340       1350       1360       1370       1380
MSSTCEPCKS RNRHSAQTEE PVQAKVFSRK NHEQLEKIIK CNRSTEISSE TGSDFSMFEA
      1390       1400       1410       1420       1430       1440
LRDTIYSEVA TLISQNESRP HFLIELFHEL QLLNTDYLRQ RALYALQDIV SRHISESHEK
      1450       1460       1470       1480       1490       1500
GENVKSVNSG TWIASNSELT PSESLATTDD ETFEKNFERE THKISEQNDA DNASVLSVSS
      1510       1520       1530       1540       1550       1560
NFEPFATDDL GNTVIHLDQA LARMREYERM KTEAESNSNM RCTCRIIEDG DGAGAGTTVN
      1570       1580       1590       1600       1610       1620
NLEETPVIEN RSSQQPVSEV STIPCPRIDT QQLDRQIKAI MKEVIPFLKE HMDEVCSSQL
      1630       1640       1650       1660       1670       1680
LTSVRRMVLT LTQQNDESKE FVKFFHKQLG SILQDSLAKF AGRKLKDCGE DLLVEISEVL
      1690       1700       1710       1720       1730       1740
FNELAFFKLM QDLDNNSITV KQRCKRKIEA TGVIQSCAKE AKRILEDHGS PAGEIDDEDK
      1750       1760       1770       1780       1790       1800
DKDETETVKQ TQTSEVYDGP KNVRSDISDQ EEDEESEGCP VSINLSKAET QALTNYGSGE
      1810       1820       1830       1840       1850       1860
DENEDEEMEE FEEGPVDVQT SLQANTEATE ENEHDEQVLQ RDFKKTAESK NVPLEREATS
      1870       1880       1890       1900       1910       1920
KNDQNNCPVK PCYLNILEDE QPLNSAAHKE SPPTVDSTQQ PNPLPLRLPE MEPLVPRVKE
      1930       1940       1950       1960       1970       1980
VKSAQETPES SLAGSPDTES PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTIYSEAD
      1990       2000       2010       2020
LRKKMVEEEQ KNHLSGEICE MQTEELAGNS ETLKEPETVG AQSI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 7 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15154-2-unknown	MATGGG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15154-1-unknown	MATGGG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84574
Q15154-1-unknown	MATGGG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84575
Q15154-2-Acetylation	ATGGGP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15154-2-Acetylation	ATGGGP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q15154-2-Acetylation	ATGGGP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110063
Q15154-2-Acetylation	ATGGGP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110064
Q15154-93-	SVPEQA...	93			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15154-93-unknown	SVPEQA...	93		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168197
Q15154-93-unknown	SVPEQA...	93		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168198
Q15154-194-unknown	GRGEPA...	194		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170737
Q15154-194-unknown	GRGEPA...	194		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170738
Q15154-194-	GRGEPA...	194			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15154-194-	GRGEPA...	194			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15154-194-	GRGEPA...	194			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15154-693-unknown	ASNLDD...	693		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12350
Q15154-693-unknown	ASNLDD...	693		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155789
Q15154-869-unknown	SDGSEN...	869		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10312
Q15154-869-unknown	SDGSEN...	869		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156745
Q15154-1263-unknown	SMPDPV...	1263		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6445
Q15154-1263-unknown	SMPDPV...	1263		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157850
Q15154-1321-unknown	MSSTCE...	1321		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000328332
Q15154-1551-unknown	DGAGAG...	1551			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15154-1551-unknown	DGAGAG...	1551		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161924
Q15154-1552-unknown	GAGAGT...	1552		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168984
Q15154-1552-	GAGAGT...	1552			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15154-1552-	GAGAGT...	1552			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15154-1552-	GAGAGT...	1552			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15154-1556-unknown	GTTVNN...	1556		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165954
Q15154-1556-	GTTVNN...	1556			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15154-1556-	GTTVNN...	1556			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15154-1556-	GTTVNN...	1556			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15154-1556-	GTTVNN...	1556			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15154-1897-	STQQPN...	1897			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15154-1897-	STQQPN...	1897			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15154-1897-unknown	STQQPN...	1897		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173363

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QEKKQK	408	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429941
...QEKKQK	408	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112830
...QEKKQK	408	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112831
...SEKLQK	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80193
...SEKLQK	491	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428123
...SEKLQK	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93009
...VISASA	692	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12350
...VISASA	692	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139239
...TKQNSN	710	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428131
...TKQNSN	710	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112828
...AVSLRS	868	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10312
...AVSLRS	868	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140234
...LESFSS	1262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6445
...LESFSS	1262	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141346
...GAQSI	2024	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GAQSI	2024	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80192

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	692	SASA.\|.ASNL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	868	SLRS.\|.SDGS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	1262	SFSS.\|.SMPD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)