O00541: Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028}

General Information

Protein names	- Pescadillo homolog {ECO:0000255\|HAMAP-Rule:MF_03028}
Gene names	PES1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00541

8 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA
        70         80         90        100        110        120
ARTFYLIKDI RFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPNYKLDHII
       130        140        150        160        170        180
KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFMH YIIAARALRK
       190        200        210        220        230        240
VFLSIKGIYY QAEVLGQPIV WITPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ
       250        260        270        280        290        300
LLNLHYPPKL EGQAQAEAKA GEGTYALDSE SCMEKLAALS ASLARVVVPA TEEEAEVDEF
       310        320        330        340        350        360
PTDGEMSAQE EDRRKELEAQ EKHKKLFEGL KFFLNREVPR EALAFIIRSF GGEVSWDKSL
       370        380        390        400        410        420
CIGATYDVTD SRITHQIVDR PGQQTSVIGR CYVQPQWVFD SVNARLLLPV AEYFSGVQLP
       430        440        450        460        470        480
PHLSPFVTEK EGDYVPPEKL KLLALQRGED PGNLNESEEE EEEDDNNEGD GDEEGENEEE
       490        500        510        520        530        540
EEDAEAGSEK EEEARLAALE EQRMEGKKPR VMAGTLKLED KQRLAQEEES EAKRLAIMMM
       550        560        570        580
KKREKYLYQK IMFGKRRKIR EANKLAEKRK AHDEAVRSEK KAKKARPE

Isoforms

- Isoform 2 of Pescadillo homolog

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00541-1-unknown	MGGLEK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00541-1-unknown	MGGLEK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84896
O00541-2-	GGLEKK...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O00541-2-unknown	GGLEKK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00541-2-unknown	GGLEKK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O00541-2-unknown	GGLEKK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162804
O00541-209-unknown	HDHPTD...	209	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5103
O00541-209-unknown	HDHPTD...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146934
O00541-299-unknown	EFPTDG...	299	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10656
O00541-484-unknown	AEAGSE...	484	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10657
O00541-484-unknown	AEAGSE...	484	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153172
O00541-513-unknown	AGTLKL...	513	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10659
O00541-513-unknown	AGTLKL...	513	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153513
O00541-525-unknown	AQEEES...	525	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13696
O00541-525-unknown	AQEEES...	525	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153626

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PYAFSH	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5103
...PYAFSH	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130265
...EAEVDE	298	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10656
...EEEEDA	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10657
...EEEEDA	483	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136598
...KPRVMA	512	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10659
...KPRVMA	512	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136935
...DKQRLA	524	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13696
...DKQRLA	524	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137049
...KARPE	588	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KARPE	588	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80514

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	208	AFSH.\|.HDHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	298	EVDE.\|.EFPT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	483	EEDA.\|.AEAG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	512	RVMA.\|.AGTL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	524	QRLA.\|.AQEE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)