P00491: Purine nucleoside phosphorylase

General Information

Protein names	- Purine nucleoside phosphorylase - PNP - 2.4.2.1 - Inosine phosphorylase - Inosine-guanosine phosphorylase
Gene names	PNP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00491

8 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY GEIPNFPRST
        70         80         90        100        110        120
VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV RVFHLLGVDT LVVTNAAGGL
       130        140        150        160        170        180
NPKFEVGDIM LIRDHINLPG FSGQNPLRGP NDERFGDRFP AMSDAYDRTM RQRALSTWKQ
       190        200        210        220        230        240
MGEQRELQEG TYVMVAGPSF ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL
       250        260        270        280
ITNKVIMDYE SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P00491-1-Acetylation	MENGYT...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00491-1-Acetylation	MENGYT...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P00491-1-Acetylation	MENGYT...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00491-32-unknown	GSGLGG...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7098
P00491-32-unknown	GSGLGG...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5312
P00491-32-unknown	GSGLGG...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3312
P00491-80-unknown	MMQGRF...	80		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451108
P00491-116-unknown	AAGGLN...	116		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3313
P00491-134-acetylation	DHINLP...	134	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00491-159-acetylation	FPAMSD...	159	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00491-174-	ALSTWK...	174			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P00491-221-unknown	TVPEVI...	221		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VAIICG	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7098
...VAIICG	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5312
...VAIICG	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3312
...EGYPLW	93	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450663
...LVVTNA	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3313
...INLPGF	140	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451108
...WKQMGE	182	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452421
...AVGMST	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7099
...PDKAS	289	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	31	IICG.\|.GSGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	31	IICG.\|.GSGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	31	IICG.\|.GSGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	115	VTNA.\|.AAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	220	GMST.\|.TVPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)