O60701: UDP-glucose 6-dehydrogenase

General Information

Protein names	- UDP-glucose 6-dehydrogenase - UDP-Glc dehydrogenase - UDP-GlcDH - UDPGDH - 1.1.1.22 {ECO:0000269\|PubMed:21502315, ECO:0000269\|PubMed:22123821, ECO:0000269\|PubMed:23106432, ECO:0000269\|PubMed:25478983, ECO:0000269\|PubMed:27966912, ECO:0000269\|PubMed:30420606, ECO:0000269\|PubMed:30457329}
Gene names	UGDH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60701

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of UDP-glucose 6-dehydrogenase - Isoform 3 of UDP-glucose 6-dehydrogenase

Sequence View

        10         20         30         40         50         60
MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV
        70         80         90        100        110        120
VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS
       130        140        150        160        170        180
NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI
       190        200        210        220        230        240
GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL
       250        260        270        280        290        300
CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
       310        320        330        340        350        360
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE
       370        380        390        400        410        420
GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF
       430        440        450        460        470        480
KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP
       490
KFSLQDPPNK KPKV         10         20         30         40         50         60
MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV
        70         80         90        100        110        120
VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS
       130        140        150        160        170        180
NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI
       190        200        210        220        230        240
GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL
       250        260        270        280        290        300
CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
       310        320        330        340        350        360
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE
       370        380        390        400        410        420
GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF
       430        440        450        460        470        480
KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP
       490
KFSLQDPPNK KPKV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O60701-1-unknown	MFEIKK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O60701-1-unknown	MFEIKK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93844
O60701-98-unknown	MGKGRA...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93845
O60701-382-unknown	HPGVSE...	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5203
O60701-382-unknown	HPGVSE...	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149466
O60701-382-unknown	HPGVSE...	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150221

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VVDLSH	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5203
...VVDLSH	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132851
...VVDLSH	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133615
...KKPKV	494	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KKPKV	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89463
...KKPKV	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89462

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	381	DLSH.\|.HPGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)