Q92917: G-patch domain and KOW motifs-containing protein

General Information

Protein names	- G-patch domain and KOW motifs-containing protein - G-patch domain-containing protein 5 - Protein MOS2 homolog - Protein T54
Gene names	GPKOW
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92917

11 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK TVEGRELQSV
        70         80         90        100        110        120
KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV VSQAVKELIA ESKKSLEERE
       130        140        150        160        170        180
NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG
       190        200        210        220        230        240
EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG
       250        260        270        280        290        300
LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN
       310        320        330        340        350        360
TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA APRSQHWLHR
       370        380        390        400        410        420
DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD
       430        440        450        460        470
RVMVVLGPQT GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92917-2-unknown	MADSKE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92917-2-Acetylation	ADSKEG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92917-2-Acetylation	ADSKEG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q92917-12-unknown	TAASTA...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14810
Q92917-15-unknown	STAPIS...	15			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92917-38-unknown	GAGPSP...	38			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92917-38-	GAGPSP...	38			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92917-38-	GAGPSP...	38			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q92917-38-	GAGPSP...	38			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q92917-38-	GAGPSP...	38			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92917-38-	GAGPSP...	38			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92917-38-	GAGPSP...	38			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92917-38-	GAGPSP...	38			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92917-59-unknown	SVKPQE...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7990
Q92917-59-unknown	SVKPQE...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6636
Q92917-59-	SVKPQE...	59			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92917-59-	SVKPQE...	59			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92917-59-	SVKPQE...	59			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92917-99-	GVVSQA...	99			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q92917-99-	GVVSQA...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q92917-99-	GVVSQA...	99			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q92917-99-unknown	GVVSQA...	99			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92917-328-unknown	NSERKR...	328		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13022

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVLPLT	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14810
...GRELQS	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7990
...GRELQS	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6636
...YIQQDN	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13022
...DTDDD	476	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	11	LPLT.\|.TAAS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	58	ELQS.\|.SVKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	58	ELQS.\|.SVKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	327	QQDN.\|.NSER	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)