Q9NSK0: Kinesin light chain 4

General Information

Protein names	- Kinesin light chain 4 - KLC 4 - Kinesin-like protein 8
Gene names	KLC4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NSK0

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Kinesin light chain 4 - Isoform 3 of Kinesin light chain 4 - Isoform 4 of Kinesin light chain 4 - Isoform 5 of Kinesin light chain 4

Sequence View

        10         20         30         40         50         60
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT IECLQQGGHE
        70         80         90        100        110        120
EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES EKQKLRAQVR RLCQENQWLR
       130        140        150        160        170        180
DELAGTQQRL QRSEQAVAQL EEEKKHLEFL GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP
       190        200        210        220        230        240
NEEEEDPSNG LSRGQGATAA QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED
       250        260        270        280        290        300
LERTSGRGHP DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN
       310        320        330        340        350        360
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ GKYEAVERYY
       370        380        390        400        410        420
QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET LYKEILTRAH VQEFGSVDDD
       430        440        450        460        470        480
HKPIWMHAEE REEMSKSRHH EGGTPYAEYG GWYKACKVSS PTVNTTLRNL GALYRRQGKL
       490        500        510        520        530        540
EAAETLEECA LRSRRQGTDP ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE
       550        560        570        580        590        600
WSGDGSGTLQ RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA
       610
PLQVSRGLSA STMDLSSSS         10         20         30         40         50         60
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT IECLQQGGHE
        70         80         90        100        110        120
EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES EKQKLRAQVR RLCQENQWLR
       130        140        150        160        170        180
DELAGTQQRL QRSEQAVAQL EEEKKHLEFL GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP
       190        200        210        220        230        240
NEEEEDPSNG LSRGQGATAA QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED
       250        260        270        280        290        300
LERTSGRGHP DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN
       310        320        330        340        350        360
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ GKYEAVERYY
       370        380        390        400        410        420
QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET LYKEILTRAH VQEFGSVDDD
       430        440        450        460        470        480
HKPIWMHAEE REEMSKSRHH EGGTPYAEYG GWYKACKVSS PTVNTTLRNL GALYRRQGKL
       490        500        510        520        530        540
EAAETLEECA LRSRRQGTDP ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE
       550        560        570        580        590        600
WSGDGSGTLQ RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA
       610
PLQVSRGLSA STMDLSSSS         10         20         30         40         50         60
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT IECLQQGGHE
        70         80         90        100        110        120
EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES EKQKLRAQVR RLCQENQWLR
       130        140        150        160        170        180
DELAGTQQRL QRSEQAVAQL EEEKKHLEFL GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP
       190        200        210        220        230        240
NEEEEDPSNG LSRGQGATAA QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED
       250        260        270        280        290        300
LERTSGRGHP DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN
       310        320        330        340        350        360
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ GKYEAVERYY
       370        380        390        400        410        420
QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET LYKEILTRAH VQEFGSVDDD
       430        440        450        460        470        480
HKPIWMHAEE REEMSKSRHH EGGTPYAEYG GWYKACKVSS PTVNTTLRNL GALYRRQGKL
       490        500        510        520        530        540
EAAETLEECA LRSRRQGTDP ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE
       550        560        570        580        590        600
WSGDGSGTLQ RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA
       610
PLQVSRGLSA STMDLSSSS         10         20         30         40         50         60
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT IECLQQGGHE
        70         80         90        100        110        120
EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES EKQKLRAQVR RLCQENQWLR
       130        140        150        160        170        180
DELAGTQQRL QRSEQAVAQL EEEKKHLEFL GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP
       190        200        210        220        230        240
NEEEEDPSNG LSRGQGATAA QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED
       250        260        270        280        290        300
LERTSGRGHP DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN
       310        320        330        340        350        360
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ GKYEAVERYY
       370        380        390        400        410        420
QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET LYKEILTRAH VQEFGSVDDD
       430        440        450        460        470        480
HKPIWMHAEE REEMSKSRHH EGGTPYAEYG GWYKACKVSS PTVNTTLRNL GALYRRQGKL
       490        500        510        520        530        540
EAAETLEECA LRSRRQGTDP ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE
       550        560        570        580        590        600
WSGDGSGTLQ RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA
       610
PLQVSRGLSA STMDLSSSS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NSK0-1-unknown	MSGLVL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79056
Q9NSK0-1-unknown	MSGLVL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79058
Q9NSK0-1-unknown	MSGLVL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107206
Q9NSK0-2-unknown	MSGLVL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NSK0-2-Acetylation	SGLVLG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NSK0-2-Acetylation	SGLVLG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NSK0-2-Acetylation	SGLVLG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9NSK0-2-Acetylation	SGLVLG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NSK0-2-Acetylation	SGLVLG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111390
Q9NSK0-2-Acetylation	SGLVLG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111392
Q9NSK0-2-Acetylation	SGLVLG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111391
Q9NSK0-369-unknown	GQLGPD...	369		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6804
Q9NSK0-369-unknown	GQLGPD...	369		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151777

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LAIYEG	368	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6804
...LAIYEG	368	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135181
...LSSSS	619	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LSSSS	619	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt74675
...LSSSS	619		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LSSSS	619		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LSSSS	619		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LSSSS	619		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	368	IYEG.\|.GQLG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)