P31153: S-adenosylmethionine synthase isoform type-2

General Information

Protein names	- S-adenosylmethionine synthase isoform type-2 - AdoMet synthase 2 - 2.5.1.6 {ECO:0000269\|PubMed:10644686, ECO:0000269\|PubMed:23189196, ECO:0000269\|PubMed:25075345} - Methionine adenosyltransferase 2 - MAT 2 {ECO:0000303\|PubMed:10644686} - Methionine adenosyltransferase II - MAT-II
Gene names	MAT2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P31153

10 N-termini

7 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA
        70         80         90        100        110        120
KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG
       130        140        150        160        170        180
VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS
       190        200        210        220        230        240
KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT
       250        260        270        280        290        300
IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW
       310        320        330        340        350        360
VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI
       370        380        390
VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY

Isoforms

- Isoform 2 of S-adenosylmethionine synthase isoform type-2

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 7 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P31153-1-unknown	MNGQLN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31153-22-unknown	SESVGE...	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5780
P31153-27-unknown	EGHPDK...	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7422
P31153-40-	AVLDAH...	40		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31153-64-	MILLAG...	64		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31153-64-unknown	MILLAG...	64	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000386353
P31153-117-	IAQGVH...	117		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31153-229-	AVVPAK...	229		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31153-229-	AVVPAK...	229		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31153-229-unknown	AVVPAK...	229	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5781
P31153-355-unknown	LRPGVI...	355	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5782

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...TFLFTS	21	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5780
...SESVGE	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7422
...EKVIKA	228	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5781
...KKNFDL	354	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5782
...GVIVRD	362	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000386353
...KKLKY	395	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KKLKY	395		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KKLKY	395		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	21	LFTS.\|.SESV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	26	SVGE.\|.EGHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	228	VIKA.\|.AVVP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	354	NFDL.\|.LRPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)