P08237: ATP-dependent 6-phosphofructokinase, muscle type {ECO:0000255|HAMAP-Rule:MF_03184}

General Information

Protein names	- ATP-dependent 6-phosphofructokinase, muscle type {ECO:0000255\|HAMAP-Rule:MF_03184} - ATP-PFK {ECO:0000255\|HAMAP-Rule:MF_03184} - PFK-M - 2.7.1.11 {ECO:0000255\|HAMAP-Rule:MF_03184} - 6-phosphofructokinase type A - Phosphofructo-1-kinase isozyme A - PFK-A - Phosphohexokinase {ECO:0000255\|HAMAP-Rule:MF_03184}
Gene names	PFKM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08237

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 6-phosphofructokinase, muscle type - Isoform 3 of 6-phosphofructokinase, muscle type - Isoform 2 of ATP-dependent 6-phosphofructokinase, muscle type - Isoform 3 of ATP-dependent 6-phosphofructokinase, muscle type

Sequence View

        10         20         30         40         50         60
MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD
        70         80         90        100        110        120
GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG
       130        140        150        160        170        180
SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS
       190        200        210        220        230        240
ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE
       250        260        270        280        290        300
EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ
       310        320        330        340        350        360
RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK
       370        380        390        400        410        420
AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR
       430        440        450        460        470        480
STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ
       490        500        510        520        530        540
ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV
       550        560        570        580        590        600
GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF
       610        620        630        640        650        660
TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG
       670        680        690        700        710        720
HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF
       730        740        750        760        770        780
QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV

        10         20         30         40         50         60
MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD
        70         80         90        100        110        120
GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG
       130        140        150        160        170        180
SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS
       190        200        210        220        230        240
ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE
       250        260        270        280        290        300
EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ
       310        320        330        340        350        360
RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK
       370        380        390        400        410        420
AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR
       430        440        450        460        470        480
STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ
       490        500        510        520        530        540
ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV
       550        560        570        580        590        600
GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF
       610        620        630        640        650        660
TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG
       670        680        690        700        710        720
HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF
       730        740        750        760        770        780
QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV

        10         20         30         40         50         60
MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD
        70         80         90        100        110        120
GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG
       130        140        150        160        170        180
SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS
       190        200        210        220        230        240
ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE
       250        260        270        280        290        300
EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ
       310        320        330        340        350        360
RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK
       370        380        390        400        410        420
AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR
       430        440        450        460        470        480
STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ
       490        500        510        520        530        540
ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV
       550        560        570        580        590        600
GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF
       610        620        630        640        650        660
TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG
       670        680        690        700        710        720
HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF
       730        740        750        760        770        780
QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV

        10         20         30         40         50         60
MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD
        70         80         90        100        110        120
GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG
       130        140        150        160        170        180
SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS
       190        200        210        220        230        240
ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE
       250        260        270        280        290        300
EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ
       310        320        330        340        350        360
RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK
       370        380        390        400        410        420
AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR
       430        440        450        460        470        480
STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ
       490        500        510        520        530        540
ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV
       550        560        570        580        590        600
GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF
       610        620        630        640        650        660
TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG
       670        680        690        700        710        720
HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF
       730        740        750        760        770        780
QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P08237-1-unknown	MTHEEH...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78488
P08237-1-unknown	MTHEEH...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101678
P08237-2-unknown	MTHEEH...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P08237-2-unknown	MTHEEH...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08237-2-Acetylation	THEEHH...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08237-2-Acetylation	THEEHH...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110767
P08237-2-Acetylation	THEEHH...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110766
P08237-2-Acetylation	THEEHH...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P08237-57-unknown	GLVDGG...	57		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5500
P08237-57-unknown	GLVDGG...	57		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139679
P08237-57-unknown	GLVDGG...	57		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143809
P08237-120-unknown	GSLTGA...	120		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11111
P08237-120-unknown	GSLTGA...	120		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143476
P08237-120-unknown	GSLTGA...	120		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146279
P08237-120-unknown	GSLTGA...	120		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08237-120-unknown	GSLTGA...	120		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P08237-544-unknown	TALNTI...	544		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11114
P08237-544-unknown	TALNTI...	544		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153567
P08237-544-unknown	TALNTI...	544		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154838

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HEGYQG	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5500
...HEGYQG	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122778
...HEGYQG	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127052
...VIGGDG	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11111
...VIGGDG	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126709
...VIGGDG	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129584
...SVGADT	543	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11114
...SVGADT	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136989
...SVGADT	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138265
...GEAAV	780	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GEAAV	780	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74106
...GEAAV	780	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74107

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	56	GYQG.\|.GLVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	119	GGDG.\|.GSLT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	543	GADT.\|.TALN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)