Q9UN86: Ras GTPase-activating protein-binding protein 2

General Information

Protein names	- Ras GTPase-activating protein-binding protein 2 - G3BP-2 - GAP SH3 domain-binding protein 2
Gene names	G3BP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UN86

14 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK PQEAVYGQND
        70         80         90        100        110        120
IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN SGQPERKFMQ TFVLAPEGSV
       130        140        150        160        170        180
PNKFYVHNDM FRYEDEVFGD SEPELDEESE DEVEEEQEER QPSPEPVQEN ANSGYYEAHP
       190        200        210        220        230        240
VTNGIEEPLE ESSHEPEPEP ESETKTEELK PQVEEKNLEE LEEKSTTPPP AEPVSLPQEP
       250        260        270        280        290        300
PKAFSWASVT SKNLPPSGTV SSSGIPPHVK APVSQPRVEA KPEVQSQPPR VREQRPRERP
       310        320        330        340        350        360
GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF FMSFGNVVEL
       370        380        390        400        410        420
RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV RLNVEEKKTR AARERETRGG
       430        440        450        460        470        480
GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD GRGPPPRGGM AQKLGSGRGT GQMEGRFTGQ

RR

Isoforms

- Isoform B of Ras GTPase-activating protein-binding protein 2

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UN86-1-	MVMEKP...	1		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UN86-1-	MVMEKP...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UN86-1-unknown	MVMEKP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75628
Q9UN86-2-unknown	VMEKPS...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UN86-2-unknown	VMEKPS...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110296
Q9UN86-2-	VMEKPS...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UN86-2-	VMEKPS...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UN86-2-	VMEKPS...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UN86-2-	VMEKPS...	2		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UN86-42-unknown	HGGVDA...	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6867
Q9UN86-42-unknown	HGGVDA...	42	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138535
Q9UN86-47-unknown	ASGKPQ...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177662
Q9UN86-47-	ASGKPQ...	47		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UN86-119-unknown	SVPNKF...	119	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166878
Q9UN86-119-	SVPNKF...	119		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UN86-119-	SVPNKF...	119		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UN86-184-unknown	GIEEPL...	184	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170350
Q9UN86-184-	GIEEPL...	184		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UN86-184-	GIEEPL...	184		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UN86-184-	GIEEPL...	184		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UN86-191-unknown	ESSHEP...	191	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8149
Q9UN86-191-unknown	ESSHEP...	191	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146296
Q9UN86-278-unknown	VEAKPE...	278	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169564
Q9UN86-278-	VEAKPE...	278		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NSSYVH	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6867
...NSSYVH	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121583
...EEPLEE	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8149
...EEPLEE	190	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129599
...TGQRR	482	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TGQRR	482	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71246

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	41	SYVH.\|.HGGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	190	PLEE.\|.ESSH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)