Q9NZI8: Insulin-like growth factor 2 mRNA-binding protein 1

General Information

Protein names	- Insulin-like growth factor 2 mRNA-binding protein 1 - IGF2 mRNA-binding protein 1 - IMP-1 - IMP1 - Coding region determinant-binding protein - CRD-BP - IGF-II mRNA-binding protein 1 - VICKZ family member 1 - Zipcode-binding protein 1 - ZBP-1
Gene names	IGF2BP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NZI8

10 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNKLYIGNLN ESVTPADLEK VFAEHKISYS GQFLVKSGYA FVDCPDEHWA MKAIETFSGK
        70         80         90        100        110        120
VELQGKRLEI EHSVPKKQRS RKIQIRNIPP QLRWEVLDSL LAQYGTVENC EQVNTESETA
       130        140        150        160        170        180
VVNVTYSNRE QTRQAIMKLN GHQLENHALK VSYIPDEQIA QGPENGRRGG FGSRGQPRQG
       190        200        210        220        230        240
SPVAAGAPAK QQQVDIPLRL LVPTQYVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA
       250        260        270        280        290        300
EKAISVHSTP EGCSSACKMI LEIMHKEAKD TKTADEVPLK ILAHNNFVGR LIGKEGRNLK
       310        320        330        340        350        360
KVEQDTETKI TISSLQDLTL YNPERTITVK GAIENCCRAE QEIMKKVREA YENDVAAMSL
       370        380        390        400        410        420
QSHLIPGLNL AAVGLFPASS SAVPPPPSSV TGAAPYSSFM QAPEQEMVQV FIPAQAVGAI
       430        440        450        460        470        480
IGKKGQHIKQ LSRFASASIK IAPPETPDSK VRMVIITGPP EAQFKAQGRI YGKLKEENFF
       490        500        510        520        530        540
GPKEEVKLET HIRVPASAAG RVIGKGGKTV NELQNLTAAE VVVPRDQTPD ENDQVIVKII
       550        560        570
GHFYASQMAQ RKIRDILAQV KQQHQKGQSN QAQARRK

Isoforms

- Isoform 2 of Insulin-like growth factor 2 mRNA-binding protein 1

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NZI8-1-unknown	MNKLYI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NZI8-1-unknown	MNKLYI...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77528
Q9NZI8-44-unknown	CPDEHW...	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8120
Q9NZI8-44-unknown	CPDEHW...	44	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138680
Q9NZI8-152-	SYIPDE...	152		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NZI8-248-unknown	STPEGC...	248	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6826
Q9NZI8-306-unknown	TETKIT...	306	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13469
Q9NZI8-306-unknown	TETKIT...	306	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145421
Q9NZI8-347-unknown	VREAYE...	347	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13471
Q9NZI8-347-unknown	VREAYE...	347	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146855
Q9NZI8-458-unknown	GPPEAQ...	458	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6827
Q9NZI8-458-unknown	GPPEAQ...	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150308
Q9NZI8-479-unknown	FFGPKE...	479	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18154
Q9NZI8-479-unknown	FFGPKE...	479	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150746
Q9NZI8-518-unknown	AAEVVV...	518	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178288
Q9NZI8-518-	AAEVVV...	518		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YAFVDC	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8120
...YAFVDC	43	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121734
...AISVHS	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6826
...KVEQDT	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13469
...KVEQDT	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128714
...EIMKKV	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13471
...EIMKKV	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130181
...MVIITG	457	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6827
...MVIITG	457	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133703
...LKEENF	478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18154
...LKEENF	478	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134145
...QARRK	577	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QARRK	577	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73146

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	43	FVDC.\|.CPDE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	247	SVHS.\|.STPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	305	EQDT.\|.TETK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	346	MKKV.\|.VREA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	457	IITG.\|.GPPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	478	EENF.\|.FFGP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)