Q01518: Adenylyl cyclase-associated protein 1

General Information

Protein names	- Adenylyl cyclase-associated protein 1 - CAP 1
Gene names	CAP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01518

18 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADMQNLVER LERAVGRLEA VSHTSDMHRG YADSPSKAGA APYVQAFDSL LAGPVAEYLK
        70         80         90        100        110        120
ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAENK LSDLLAPISE QIKEVITFRE
       130        140        150        160        170        180
KNRGSKLFNH LSAVSESIQA LGWVAMAPKP GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV
       190        200        210        220        230        240
DWVKAYLSIW TELQAYIKEF HTTGLAWSKT GPVAKELSGL PSGPSAGSCP PPPPPCPPPP
       250        260        270        280        290        300
PVSTISCSYE SASRSSLFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GPVRSGPKPF
       310        320        330        340        350        360
SAPKPQTSPS PKRATKKEPA VLELEGKKWR VENQENVSNL VIEDTELKQV AYIYKCVNTT
       370        380        390        400        410        420
LQIKGKINSI TVDNCKKLGL VFDDVVGIVE IINSKDVKVQ VMGKVPTISI NKTDGCHAYL
       430        440        450        460        470
SKNSLDCEIV SAKSSEMNVL IPTEGGDFNE FPVPEQFKTL WNGQKLVTTV TEIAG

Isoforms

- Isoform 2 of Adenylyl cyclase-associated protein 1

Sequence View

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Protein Neighborhood

Domains & Features

18 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01518-1-unknown	MADMQN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69263
Q01518-2-unknown	MADMQN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01518-2-unknown	MADMQN...	1		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q01518-2-Acetylation	ADMQNL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01518-2-Acetylation	ADMQNL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q01518-2-Acetylation	ADMQNL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q01518-2-Acetylation	ADMQNL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q01518-2-Acetylation	ADMQNL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q01518-2-Acetylation	ADMQNL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110582
Q01518-4-acetylation	MQNLVE...	4	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q01518-4-acetylation	MQNLVE...	4	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163316
Q01518-20-	AVSHTS...	20			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q01518-20-	AVSHTS...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q01518-20-	AVSHTS...	20			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q01518-20-	AVSHTS...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01518-20-	AVSHTS...	20			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q01518-20-unknown	AVSHTS...	20			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q01518-20-unknown	AVSHTS...	20			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q01518-22-	SHTSDM...	22			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q01518-90-unknown	ASQCQQ...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7719
Q01518-90-unknown	ASQCQQ...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6209
Q01518-90-unknown	ASQCQQ...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3950
Q01518-90-unknown	ASQCQQ...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141750
Q01518-125-unknown	SKLFNH...	125		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q01518-125-unknown	SKLFNH...	125		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197328
Q01518-283-	NPALKA...	283			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q01518-283-unknown	NPALKA...	283		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177418
Q01518-301-	SAPKPQ...	301			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q01518-301-unknown	SAPKPQ...	301		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177420
Q01518-314-	ATKKEP...	314			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q01518-314-unknown	ATKKEP...	314		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177422
Q01518-317-	KEPAVL...	317			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q01518-317-	KEPAVL...	317			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q01518-317-	KEPAVL...	317			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q01518-317-	KEPAVL...	317			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q01518-317-unknown	KEPAVL...	317			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q01518-317-unknown	KEPAVL...	317		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161339
Q01518-318-unknown	EPAVLE...	318		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17832
Q01518-318-unknown	EPAVLE...	318		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150271

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALLVTA	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7719
...ALLVTA	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6209
...ALLVTA	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3950
...ALLVTA	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124933
...RATKKE	317	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17832
...RATKKE	317	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133664
...TEIAG	475	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TEIAG	475	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64881

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	89	LVTA.\|.ASQC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	89	LVTA.\|.ASQC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	89	LVTA.\|.ASQC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	317	TKKE.\|.EPAV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)