P54577: Tyrosine--tRNA ligase, cytoplasmic

General Information

Protein names	- Tyrosine--tRNA ligase, cytoplasmic - 6.1.1.1 - Tyrosyl-tRNA synthetase - TyrRS - Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
Gene names	YARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54577

12 N-termini

7 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA
        70         80         90        100        110        120
DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG
       130        140        150        160        170        180
TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD
       190        200        210        220        230        240
AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED
       250        260        270        280        290        300
VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA
       310        320        330        340        350        360
AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP
       370        380        390        400        410        420
EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV
       430        440        450        460        470        480
VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE
       490        500        510        520
LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 7 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54577-1-Acetylation	MGDAPS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54577-1-Acetylation	MGDAPS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P54577-2-Acetylation	GDAPSP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54577-2-Acetylation	GDAPSP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P54577-2-Acetylation	GDAPSP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P54577-2-Acetylation	GDAPSP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54577-7-unknown	PEEKLH...	7		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P54577-41-unknown	GTATTG...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6028
P54577-41-unknown	GTATTG...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7568
P54577-42-unknown	TATTGK...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3864
P54577-42-unknown	TATTGK...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6029
P54577-42-unknown	TATTGK...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7569
P54577-210-	LMNPMV...	210			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P54577-299-	FAAEVV...	299			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P54577-299-	FAAEVV...	299			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P54577-301-unknown	AEVVHP...	301		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6030
P54577-380-unknown	KHPDAD...	380		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6031
P54577-380-	KHPDAD...	380			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P54577-386-unknown	SLYVEK...	386		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11685
P54577-461-unknown	SAPGEH...	461		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7570

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKIYWG	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6028
...LKIYWG	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7568
...KIYWGT	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3864
...KIYWGT	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6029
...KIYWGT	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7569
...EKDFAA	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6030
...IITVEK	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6031
...HPDADS	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11685
...DPPAGS	460	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7570
...GGNIS	528	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	40	IYWG.\|.GTAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	40	IYWG.\|.GTAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	41	YWGT.\|.TATT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	41	YWGT.\|.TATT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	41	YWGT.\|.TATT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	300	DFAA.\|.AEVV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	379	TVEK.\|.KHPD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	385	DADS.\|.SLYV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	460	PAGS.\|.SAPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)