P61289: Proteasome activator complex subunit 3

General Information

Protein names	- Proteasome activator complex subunit 3 - 11S regulator complex subunit gamma - REG-gamma - Activator of multicatalytic protease subunit 3 - Ki nuclear autoantigen - Proteasome activator 28 subunit gamma - PA28g - PA28gamma
Gene names	PSME3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61289

5 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Proteasome activator complex subunit 3 - Isoform 3 of Proteasome activator complex subunit 3

Sequence View

        10         20         30         40         50         60
MASLLKVDQE VKLKVDSFRE RITSEAEDLV ANFFPKKLLE LDSFLKEPIL NIHDLTQIHS
        70         80         90        100        110        120
DMNLPVPDPI LLTNSHDGLD GPTYKKRRLD ECEEAFQGTK VFVMPNGMLK SNQQLVDIIE
       130        140        150        160        170        180
KVKPEIRLLI EKCNTVKMWV QLLIPRIEDG NNFGVSIQEE TVAELRTVES EAASYLDQIS
       190        200        210        220        230        240
RYYITRAKLV SKIAKYPHVE DYRRTVTEID EKEYISLRLI ISELRNQYVT LHDMILKNIE
       250
KIKRPRSSNA ETLY         10         20         30         40         50         60
MASLLKVDQE VKLKVDSFRE RITSEAEDLV ANFFPKKLLE LDSFLKEPIL NIHDLTQIHS
        70         80         90        100        110        120
DMNLPVPDPI LLTNSHDGLD GPTYKKRRLD ECEEAFQGTK VFVMPNGMLK SNQQLVDIIE
       130        140        150        160        170        180
KVKPEIRLLI EKCNTVKMWV QLLIPRIEDG NNFGVSIQEE TVAELRTVES EAASYLDQIS
       190        200        210        220        230        240
RYYITRAKLV SKIAKYPHVE DYRRTVTEID EKEYISLRLI ISELRNQYVT LHDMILKNIE
       250
KIKRPRSSNA ETLY

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61289-2-unknown	MASLLK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61289-1-unknown	MASLLK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86403
P61289-2-Acetylation	ASLLKV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61289-2-Acetylation	ASLLKV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P61289-2-Acetylation	ASLLKV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P61289-2-Acetylation	ASLLKV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111067
P61289-74-unknown	NSHDGL...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6085
P61289-74-unknown	NSHDGL...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140913
P61289-81-unknown	GPTYKK...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2606
P61289-81-unknown	GPTYKK...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2879
P61289-81-unknown	GPTYKK...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1965
P61289-81-unknown	GPTYKK...	81		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141341

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PILLTN	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6085
...PILLTN	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124057
...HDGLDG	80	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2606
...HDGLDG	80	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2879
...HDGLDG	80	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1965
...HDGLDG	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124508
...AETLY	254	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AETLY	254	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82021
...AETLY	254		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AETLY	254		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	73	LLTN.\|.NSHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	80	GLDG.\|.GPTY	inferred from experiment	unknown	MEROPS	Nomura Y	Araya R et al.:Yeast two-hybrid screening usin... (C14.003)	11859414,
CASP7_HUMAN	80	GLDG.\|.GPTY	inferred from experiment	unknown	MEROPS	Nomura Y	Araya R et al.:Yeast two-hybrid screening usin... (C14.003)	11859414,
CASP3_HUMAN	80	GLDG.\|.GPTY	inferred from experiment	unknown	MEROPS	Nomura Y	Araya R et al.:Yeast two-hybrid screening usin... (C14.003)	11859414,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)