Q13619: Cullin-4A

General Information

Protein names	- Cullin-4A - CUL-4A
Gene names	CUL4A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13619

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ
        70         80         90        100        110        120
DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP
       130        140        150        160        170        180
FREDSLDSVL FLKKINTCWQ DHCRQMIMIR SIFLFLDRTY VLQNSTLPSI WDMGLELFRT
       190        200        210        220        230        240
HIISDKMVQS KTIDGILLLI ERERSGEAVD RSLLRSLLGM LSDLQVYKDS FELKFLEETN
       250        260        270        280        290        300
CLYAAEGQRL MQEREVPEYL NHVSKRLEEE GDRVITYLDH STQKPLIACV EKQLLGEHLT
       310        320        330        340        350        360
AILQKGLDHL LDENRVPDLA QMYQLFSRVR GGQQALLQHW SEYIKTFGTA IVINPEKDKD
       370        380        390        400        410        420
MVQDLLDFKD KVDHVIEVCF QKNERFVNLM KESFETFINK RPNKPAELIA KHVDSKLRAG
       430        440        450        460        470        480
NKEATDEELE RTLDKIMILF RFIHGKDVFE AFYKKDLAKR LLVGKSASVD AEKSMLSKLK
       490        500        510        520        530        540
HECGAAFTSK LEGMFKDMEL SKDIMVHFKQ HMQNQSDSGP IDLTVNILTM GYWPTYTPME
       550        560        570        580        590        600
VHLTPEMIKL QEVFKAFYLG KHSGRKLQWQ TTLGHAVLKA EFKEGKKEFQ VSLFQTLVLL
       610        620        630        640        650        660
MFNEGDGFSF EEIKMATGIE DSELRRTLQS LACGKARVLI KSPKGKEVED GDKFIFNGEF
       670        680        690        700        710        720
KHKLFRIKIN QIQMKETVEE QVSTTERVFQ DRQYQIDAAI VRIMKMRKTL GHNLLVSELY
       730        740        750
NQLKFPVKPG DLKKRIESLI DRDYMERDKD NPNQYHYVA

Isoforms

- Isoform 2 of Cullin-4A

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13619-1-unknown	MADEAP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13619-8-unknown	KGSFSA...	8		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13619-8-	KGSFSA...	8		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13619-20-	GLTKPA...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13619-20-unknown	GLTKPA...	20		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13619-27-unknown	LAAAPA...	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3996
Q13619-29-unknown	AAPAKP...	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6352
Q13619-101-unknown	MLYKQL...	101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72144

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...TKPAAL	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3996
...PAALAA	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6352
...YHYVA	759		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...YHYVA	759		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...YHYVA	759	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...YHYVA	759	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt67762
...YHYVA	759		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...YHYVA	759		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	26	PAAL.\|.LAAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	28	ALAA.\|.AAPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)