Q14765: Signal transducer and activator of transcription 4

General Information

Protein names	- Signal transducer and activator of transcription 4
Gene names	STAT4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14765

3 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIEN QDWEAASNNE TMATILLQNL
        70         80         90        100        110        120
LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH VAVVISNCLR EERRILAAAN
       130        140        150        160        170        180
MPVQGPLEKS LQSSSVSERQ RNVEHKVAAI KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT
       190        200        210        220        230        240
MDQSDKNSAM VNQEVLTLQE MLNSLDFKRK EALSKMTQII HETDLLMNTM LIEELQDWKR
       250        260        270        280        290        300
RQQIACIGGP LHNGLDQLQN CFTLLAESLF QLRRQLEKLE EQSTKMTYEG DPIPMQRTHM
       310        320        330        340        350        360
LERVTFLIYN LFKNSFVVER QPCMPTHPQR PLVLKTLIQF TVKLRLLIKL PELNYQVKVK
       370        380        390        400        410        420
ASIDKNVSTL SNRRFVLCGT NVKAMSIEES SNGSLSVEFR HLQPKEMKSS AGGKGNEGCH
       430        440        450        460        470        480
MVTEELHSIT FETQICLYGL TIDLETSSLP VVMISNVSQL PNAWASIIWY NVSTNDSQNL
       490        500        510        520        530        540
VFFNNPPPAT LSQLLEVMSW QFSSYVGRGL NSDQLHMLAE KLTVQSSYSD GHLTWAKFCK
       550        560        570        580        590        600
EHLPGKSFTF WTWLEAILDL IKKHILPLWI DGYVMGFVSK EKERLLLKDK MPGTFLLRFS
       610        620        630        640        650        660
ESHLGGITFT WVDHSESGEV RFHSVEPYNK GRLSALPFAD ILRDYKVIMA ENIPENPLKY
       670        680        690        700        710        720
LYPDIPKDKA FGKHYSSQPC EVSRPTERGD KGYVPSVFIP ISTIRSDSTE PHSPSDLLPM
       730        740
SPSVYAVLRE NLSPTTIETA MKSPYSAE

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q14765-1-unknown	MSQWNQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14765-28-unknown	MEIRHL...	28	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403238
Q14765-692-unknown	GYVPSV...	692	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6407

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FYDDNF	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414322
...KNLLLI	79	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412397
...NMPVQG	124	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403238
...ERGDKG	691	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6407
...PYSAE	748	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	691	GDKG.\|.GYVP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)