Q16543: Hsp90 co-chaperone Cdc37

General Information

Protein names	- Hsp90 co-chaperone Cdc37 - Hsp90 chaperone protein kinase-targeting subunit - p50Cdc37 - Hsp90 co-chaperone Cdc37, N-terminally processed
Gene names	CDC37
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16543

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK
        70         80         90        100        110        120
VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS
       130        140        150        160        170        180
KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH
       190        200        210        220        230        240
LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK
       250        260        270        280        290        300
IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES
       310        320        330        340        350        360
LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG
       370
DPLLEAVPKT GDEKDVSV

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16543-1-Acetylation	MVDYSV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16543-2-Acetylation	VDYSVW...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16543-2-Acetylation	VDYSVW...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q16543-9-	HIEVSD...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16543-9-	HIEVSD...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q16543-9-	HIEVSD...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q16543-68-	LKELEV...	68			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q16543-122-	DGFSKS...	122			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q16543-131-unknown	TKPEKT...	131		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6489
Q16543-131-unknown	TKPEKT...	131		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7876

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KSMVNT	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6489
...KSMVNT	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7876
...YESLPE	302	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465724
...AISKMD	324	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467747
...KDVSV	378	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	130	MVNT.\|.TKPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	130	MVNT.\|.TKPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)