P12081: Histidine--tRNA ligase, cytoplasmic

General Information

Protein names	- Histidine--tRNA ligase, cytoplasmic - 6.1.1.21 - Histidyl-tRNA synthetase - HisRS
Gene names	HARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12081

5 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Histidine--tRNA ligase, cytoplasmic - Isoform 3 of Histidine--tRNA ligase, cytoplasmic - Isoform 4 of Histidine--tRNA ligase, cytoplasmic

Sequence View

        10         20         30         40         50         60
MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK
        70         80         90        100        110        120
GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLMGKYGED SKLIYDLKDQ
       130        140        150        160        170        180
GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG
       190        200        210        220        230        240
NFDPMIPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK
       250        260        270        280        290        300
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG
       310        320        330        340        350        360
DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE PLGVGSVAAG
       370        380        390        400        410        420
GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKIRTTETQ VLVASAQKKL
       430        440        450        460        470        480
LEERLKLVSE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS
       490        500
VTSREEVDVR REDLVEEIKR RTGQPLCIC         10         20         30         40         50         60
MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK
        70         80         90        100        110        120
GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLMGKYGED SKLIYDLKDQ
       130        140        150        160        170        180
GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG
       190        200        210        220        230        240
NFDPMIPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK
       250        260        270        280        290        300
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG
       310        320        330        340        350        360
DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE PLGVGSVAAG
       370        380        390        400        410        420
GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKIRTTETQ VLVASAQKKL
       430        440        450        460        470        480
LEERLKLVSE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS
       490        500
VTSREEVDVR REDLVEEIKR RTGQPLCIC         10         20         30         40         50         60
MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK
        70         80         90        100        110        120
GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLMGKYGED SKLIYDLKDQ
       130        140        150        160        170        180
GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG
       190        200        210        220        230        240
NFDPMIPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK
       250        260        270        280        290        300
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG
       310        320        330        340        350        360
DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE PLGVGSVAAG
       370        380        390        400        410        420
GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKIRTTETQ VLVASAQKKL
       430        440        450        460        470        480
LEERLKLVSE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS
       490        500
VTSREEVDVR REDLVEEIKR RTGQPLCIC

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P12081-1-unknown	MAERAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91179
P12081-1-unknown	MAERAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91180
P12081-1-unknown	MAERAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91181
P12081-2-unknown	MAERAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12081-2-Acetylation	AERAAL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12081-2-Acetylation	AERAAL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111267
P12081-2-Acetylation	AERAAL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111268
P12081-2-Acetylation	AERAAL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111269
P12081-49-unknown	ESKQKF...	49		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11193
P12081-49-unknown	ESKQKF...	49		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139108
P12081-236-unknown	SSVDKL...	236		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5562
P12081-236-unknown	SSVDKL...	236		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145762
P12081-236-unknown	SSVDKL...	236		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146476
P12081-236-unknown	SSVDKL...	236		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147201

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QLGPDE	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11193
...QLGPDE	48	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122179
...QLGPDE	48	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122180
...QLGPDE	48	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122182
...FRTICS	235	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5562
...FRTICS	235	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129059
...FRTICS	235	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129784
...FRTICS	235	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130541
...PLCIC	509		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PLCIC	509		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...PLCIC	509	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...PLCIC	509	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt86798
...PLCIC	509	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt86797
...PLCIC	509	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt86799
...PLCIC	509		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PLCIC	509		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	48	GPDE.\|.ESKQ	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
CATL1_HUMAN	235	TICS.\|.SSVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)