O00232: 26S proteasome non-ATPase regulatory subunit 12

General Information

Protein names	- 26S proteasome non-ATPase regulatory subunit 12 - 26S proteasome regulatory subunit RPN5 - 26S proteasome regulatory subunit p55
Gene names	PSMD12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00232

7 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL EKQTRTASDM
        70         80         90        100        110        120
VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI
       130        140        150        160        170        180
KLRLIDTLRM VTEGKIYVEI ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK
       190        200        210        220        230        240
ERVEFILEQM RLCLAVKDYI RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY
       250        260        270        280        290        300
LSICKHYRAI YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP
       310        320        330        340        350        360
KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR WKDLKNRVVE
       370        380        390        400        410        420
HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK TIFAKVDRLA GIINFQRPKD
       430        440        450
PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE MIHNLQ

Isoforms

- Isoform 2 of 26S proteasome non-ATPase regulatory subunit 12

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00232-1-unknown	MADGGS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86365
O00232-2-unknown	MADGGS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00232-2-Acetylation	ADGGSE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00232-2-Acetylation	ADGGSE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111175
O00232-20-	YSATVD...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00232-20-	YSATVD...	20			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00232-20-	YSATVD...	20			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O00232-20-unknown	YSATVD...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1383
O00232-20-unknown	YSATVD...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10633
O00232-277-unknown	APFDNE...	277		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5088
O00232-277-unknown	APFDNE...	277		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148726
O00232-335-unknown	SPATDV...	335		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5090
O00232-335-unknown	SPATDV...	335		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150231

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KMEVDY	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1383
...KMEVDY	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10633
...LYVILA	276	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5088
...LYVILA	276	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132102
...KGSLES	334	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5090
...KGSLES	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133625
...IHNLQ	456	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IHNLQ	456	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81983

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	19	EVDY.\|.YSAT	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> PSD12_HUMAN @19
GRAB_HUMAN	19	EVDY.\|.YSAT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	276	VILA.\|.APFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	334	SLES.\|.SPAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)