Q9BZI7: Regulator of nonsense transcripts 3B

General Information

Protein names	- Regulator of nonsense transcripts 3B - Nonsense mRNA reducing factor 3B - Up-frameshift suppressor 3 homolog B - hUpf3B - Up-frameshift suppressor 3 homolog on chromosome X - hUpf3p-X
Gene names	UPF3B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BZI7

6 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKEEKEHRPK EKRVTLLTPA GATGSGGGTS GDSSKGEDKQ DRNKEKKEAL SKVVIRRLPP
        70         80         90        100        110        120
TLTKEQLQEH LQPMPEHDYF EFFSNDTSLY PHMYARAYIN FKNQEDIILF RDRFDGYVFL
       130        140        150        160        170        180
DNKGQEYPAI VEFAPFQKAA KKKTKKRDTK VGTIDDDPEY RKFLESYATD NEKMTSTPET
       190        200        210        220        230        240
LLEEIEAKNR ELIAKKTTPL LSFLKNKQRM REEKREERRR REIERKRQRE EERRKWKEEE
       250        260        270        280        290        300
KRKRKDIEKL KKIDRIPERD KLKDEPKIKV HRFLLQAVNQ KNLLKKPEKG DEKELDKREK
       310        320        330        340        350        360
AKKLDKENLS DERASGQSCT LPKRSDSELK DEKPKRPEDE SGRDYRERER EYERDQERIL
       370        380        390        400        410        420
RERERLKRQE EERRRQKERY EKEKTFKRKE EEMKKEKDTL RDKGKKAEST ESIGSSEKTE
       430        440        450        460        470        480
KKEEVVKRDR IRNKDRPAMQ LYQPGARSRN RLCPPDDSTK SGDSAAERKQ ESGISHRKEG

GEE

Isoforms

- Isoform 2 of Regulator of nonsense transcripts 3B

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9BZI7-1-unknown	MKEEKE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BZI7-1-unknown	MKEEKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt87277
Q9BZI7-18-unknown	TPAGAT...	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6758
Q9BZI7-18-unknown	TPAGAT...	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8074
Q9BZI7-18-unknown	TPAGAT...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136715
Q9BZI7-33-unknown	SSKGED...	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13266
Q9BZI7-33-unknown	SSKGED...	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137830
Q9BZI7-51-unknown	SKVVIR...	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14978
Q9BZI7-51-unknown	SKVVIR...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139274
Q9BZI7-171-unknown	NEKMTS...	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13268
Q9BZI7-171-unknown	NEKMTS...	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145576
Q9BZI7-310-unknown	SDERAS...	310	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14980
Q9BZI7-310-unknown	SDERAS...	310	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149796

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RVTLLT	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6758
...RVTLLT	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8074
...GTSGDS	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13266
...GTSGDS	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120831
...KKEALS	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14978
...KKEALS	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122349
...SYATDN	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13268
...SYATDN	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128874
...DKENLS	309	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14980
...DKENLS	309	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133187
...EGGEE	483	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EGGEE	483	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82895

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	17	TLLT.\|.TPAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	17	TLLT.\|.TPAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	32	SGDS.\|.SSKG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	50	EALS.\|.SKVV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	170	ATDN.\|.NEKM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	309	ENLS.\|.SDER	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)