P19525: Interferon-induced, double-stranded RNA-activated protein kinase

General Information

Protein names	- Interferon-induced, double-stranded RNA-activated protein kinase - 2.7.11.1 - Eukaryotic translation initiation factor 2-alpha kinase 2 - eIF-2A protein kinase 2 - Interferon-inducible RNA-dependent protein kinase - P1/eIF-2A protein kinase - Protein kinase RNA-activated - PKR - Protein kinase R {ECO:0000303\|PubMed:11438532} - Tyrosine-protein kinase EIF2AK2 - 2.7.10.2 - p68 kinase
Gene names	EIF2AK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P19525

7 N-termini

5 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGDLSAGFF MEELNTYRQK QGVVLKYQEL PNSGPPHDRR FTFQVIIDGR EFPEGEGRSK
        70         80         90        100        110        120
KEAKNAAAKL AVEILNKEKK AVSPLLLTTT NSSEGLSMGN YIGLINRIAQ KKRLTVNYEQ
       130        140        150        160        170        180
CASGVHGPEG FHYKCKMGQK EYSIGTGSTK QEAKQLAAKL AYLQILSEET SVKSDYLSSG
       190        200        210        220        230        240
SFATTCESQS NSLVTSTLAS ESSSEGDFSA DTSEINSNSD SLNSSSLLMN GLRNNQRKAK
       250        260        270        280        290        300
RSLAPRFDLP DMKETKYTVD KRFGMDFKEI ELIGSGGFGQ VFKAKHRIDG KTYVIKRVKY
       310        320        330        340        350        360
NNEKAEREVK ALAKLDHVNI VHYNGCWDGF DYDPETSDDS LESSDYDPEN SKNSSRSKTK
       370        380        390        400        410        420
CLFIQMEFCD KGTLEQWIEK RRGEKLDKVL ALELFEQITK GVDYIHSKKL IHRDLKPSNI
       430        440        450        460        470        480
FLVDTKQVKI GDFGLVTSLK NDGKRTRSKG TLRYMSPEQI SSQDYGKEVD LYALGLILAE
       490        500        510        520        530        540
LLHVCDTAFE TSKFFTDLRD GIISDIFDKK EKTLLQKLLS KKPEDRPNTS EILRTLTVWK
       550
KSPEKNERHT C

Isoforms

- Isoform 2 of Interferon-induced, double-stranded RNA-activated protein kinase

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P19525-1-unknown	MAGDLS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73501
P19525-2-unknown	MAGDLS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P19525-2-Acetylation	AGDLSA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P19525-2-Acetylation	AGDLSA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P19525-2-Acetylation	AGDLSA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P19525-2-Acetylation	AGDLSA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P19525-2-Acetylation	AGDLSA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111645
P19525-127-unknown	GPEGFH...	127		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5649
P19525-127-unknown	GPEGFH...	127		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143759
P19525-219-unknown	SDSLNS...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11319
P19525-219-unknown	SDSLNS...	219		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147308
P19525-252-unknown	MKETKY...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2833
P19525-252-unknown	MKETKY...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1683
P19525-252-unknown	MKETKY...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3062
P19525-275-unknown	SGGFGQ...	275		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3677

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASGVHG	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5649
...ASGVHG	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127001
...EINSNS	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11319
...EINSNS	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130651
...FDLPDM	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2833
...FDLPDM	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1683
...FDLPDM	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3062
...FDLPDM	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131834
...IELIGS	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3677
...ERHTC	551	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ERHTC	551	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69119

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	126	GVHG.\|.GPEG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	218	NSNS.\|.SDSL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP7_HUMAN	251	LPDM.\|.MKET	inferred from experiment	unknown	MEROPS	Vandenabeele P	Saelens X et al.:Translation inhibition in apopt... (C14.003)	11555640,
CASP3_HUMAN	251	LPDM.\|.MKET	inferred from experiment	unknown	MEROPS	Vandenabeele P	Saelens X et al.:Translation inhibition in apopt... (C14.003)	11555640,
CASP8_HUMAN	251	LPDM.\|.MKET	inferred from experiment	unknown	MEROPS	Vandenabeele P	Saelens X et al.:Translation inhibition in apopt... (C14.003)	11555640,
CATB_HUMAN	274	LIGS.\|.SGGF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)