P49915: GMP synthase [glutamine-hydrolyzing]

General Information

Protein names	- GMP synthase glutamine-hydrolyzing] - 6.3.5.2 - GMP synthetase - Glutamine amidotransferase
Gene names	GMPS
Organism	Homo sapiens
Protease Family
Protease ID	C26.950
Chromosome location
UniProt ID	P49915

3 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALCNGDSKL ENAGGDLKDG HHHYEGAVVI LDAGAQYGKV IDRRVRELFV QSEIFPLETP
        70         80         90        100        110        120
AFAIKEQGFR AIIISGGPNS VYAEDAPWFD PAIFTIGKPV LGICYGMQMM NKVFGGTVHK
       130        140        150        160        170        180
KSVREDGVFN ISVDNTCSLF RGLQKEEVVL LTHGDSVDKV ADGFKVVARS GNIVAGIANE
       190        200        210        220        230        240
SKKLYGAQFH PEVGLTENGK VILKNFLYDI AGCSGTFTVQ NRELECIREI KERVGTSKVL
       250        260        270        280        290        300
VLLSGGVDST VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA
       310        320        330        340        350        360
HSFYNGTTTL PISDEDRTPR KRISKTLNMT TSPEEKRKII GDTFVKIANE VIGEMNLKPE
       370        380        390        400        410        420
EVFLAQGTLR PDLIESASLV ASGKAELIKT HHNDTELIRK LREEGKVIEP LKDFHKDEVR
       430        440        450        460        470        480
ILGRELGLPE ELVSRHPFPG PGLAIRVICA EEPYICKDFP ETNNILKIVA DFSASVKKPH
       490        500        510        520        530        540
TLLQRVKACT TEEDQEKLMQ ITSLHSLNAF LLPIKTVGVQ GDCRSYSYVC GISSKDEPDW
       550        560        570        580        590        600
ESLIFLARLI PRMCHNVNRV VYIFGPPVKE PPTDVTPTFL TTGVLSTLRQ ADFEAHNILR
       610        620        630        640        650        660
ESGYAGKISQ MPVILTPLHF DRDPLQKQPS CQRSVVIRTF ITSDFMTGIP ATPGNEIPVE
       670        680        690
VVLKMVTEIK KIPGISRIMY DLTSKPPGTT EWE

Isoforms

- Isoform 2 of GMP synthase [glutamine-hydrolyzing]

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P49915-2-unknown	MALCNG...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49915-2-Acetylation	ALCNGD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49915-187-unknown	AQFHPE...	187		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5946
P49915-187-unknown	AQFHPE...	187		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7523
P49915-187-unknown	AQFHPE...	187		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3815
P49915-187-unknown	AQFHPE...	187		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141702

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KKLYGA	186	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5946
...KKLYGA	186	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7523
...KKLYGA	186	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3815
...KKLYGA	186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124884
...TTEWE	693		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...TTEWE	693	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TTEWE	693	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt72283
...TTEWE	693		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	186	LYGA.\|.AQFH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	186	LYGA.\|.AQFH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	186	LYGA.\|.AQFH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)