Q53EL6: Programmed cell death protein 4

General Information

Protein names	- Programmed cell death protein 4 - Neoplastic transformation inhibitor protein - Nuclear antigen H731-like - Protein 197/15a
Gene names	PDCD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q53EL6

8 N-termini

6 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI NEARINAKAK
        70         80         90        100        110        120
RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG
       130        140        150        160        170        180
KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD
       190        200        210        220        230        240
TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF
       250        260        270        280        290        300
DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV
       310        320        330        340        350        360
LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH
       370        380        390        400        410        420
HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP
       430        440        450        460
HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY

Isoforms

- Isoform 2 of Programmed cell death protein 4

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q53EL6-1-Acetylation	MDVENE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q53EL6-316-unknown	GSGGGQ...	316		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7890
Q53EL6-316-unknown	GSGGGQ...	316		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150010
Q53EL6-317-unknown	SGGGQQ...	317		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6508
Q53EL6-317-unknown	SGGGQQ...	317		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7892
Q53EL6-317-unknown	SGGGQQ...	317		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150030
Q53EL6-340-unknown	LSGDIS...	340		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4128
Q53EL6-340-unknown	LSGDIS...	340		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150500
Q53EL6-341-unknown	SGDISE...	341		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6510
Q53EL6-341-unknown	SGDISE...	341		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7894
Q53EL6-341-unknown	SGDISE...	341		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150529
Q53EL6-342-unknown	GDISEA...	342		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6512
Q53EL6-342-unknown	GDISEA...	342		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150549
Q53EL6-408-	IYNEIP...	408			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q53EL6-408-unknown	IYNEIP...	408		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178230

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KDSVWG	315	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7890
...KDSVWG	315	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133402
...DSVWGS	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6508
...DSVWGS	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7892
...DSVWGS	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133422
...LKEYLL	339	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4128
...LKEYLL	339	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133896
...KEYLLS	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6510
...KEYLLS	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7894
...KEYLLS	340	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133925
...EYLLSG	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6512
...EYLLSG	341	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133946
...KPESY	469	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KPESY	469	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80257

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	315	SVWG.\|.GSGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	316	VWGS.\|.SGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	316	VWGS.\|.SGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	339	EYLL.\|.LSGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	340	YLLS.\|.SGDI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	340	YLLS.\|.SGDI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	341	LLSG.\|.GDIS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)