Q08211: ATP-dependent RNA helicase A {ECO:0000305}
Protein names | - ATP-dependent RNA helicase A {ECO:0000305} - 3.6.4.13 {ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:20510246, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:8690889} - DEAH box protein 9 - DExH-box helicase 9 {ECO:0000312|HGNC:HGNC:2750} - Leukophysin {ECO:0000303|PubMed:8690889} - LKP {ECO:0000303|PubMed:8690889} - Nuclear DNA helicase II {ECO:0000303|PubMed:1537828, ECO:0000303|PubMed:8344961, ECO:0000303|PubMed:9111062} - NDH II {ECO:0000303|PubMed:8344961, ECO:0000303|PubMed:9111062} - RNA helicase A {ECO:0000303|PubMed:9111062} |
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Gene names | DHX9 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q08211 |
22
N-termini
9
C-termini
9
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGDVKNFLYA WCGKRKMTPS YEIRAVGNKN RQKFMCEVQV EGYNYTGMGN STNKKDAQSN
70 80 90 100 110 120
AARDFVNYLV RINEIKSEEV PAFGVASPPP LTDTPDTTAN AEGDLPTTMG GPLPPHLALK
130 140 150 160 170 180
AENNSEVGAS GYGVPGPTWD RGANLKDYYS RKEEQEVQAT LESEEVDLNA GLHGNWTLEN
190 200 210 220 230 240
AKARLNQYFQ KEKIQGEYKY TQVGPDHNRS FIAEMTIYIK QLGRRIFARE HGSNKKLAAQ
250 260 270 280 290 300
SCALSLVRQL YHLGVVEAYS GLTKKKEGET VEPYKVNLSQ DLEHQLQNII QELNLEILPP
310 320 330 340 350 360
PEDPSVPVAL NIGKLAQFEP SQRQNQVGVV PWSPPQSNWN PWTSSNIDEG PLAFATPEQI
370 380 390 400 410 420
SMDLKNELMY QLEQDHDLQA ILQERELLPV KKFESEILEA ISQNSVVIIR GATGCGKTTQ
430 440 450 460 470 480
VPQFILDDFI QNDRAAECNI VVTQPRRISA VSVAERVAFE RGEEPGKSCG YSVRFESILP
490 500 510 520 530 540
RPHASIMFCT VGVLLRKLEA GIRGISHVIV DEIHERDINT DFLLVVLRDV VQAYPEVRIV
550 560 570 580 590 600
LMSATIDTSM FCEYFFNCPI IEVYGRTYPV QEYFLEDCIQ MTHFVPPPKD KKKKDKDDDG
610 620 630 640 650 660
GEDDDANCNL ICGDEYGPET RLSMSQLNEK ETPFELIEAL LKYIETLNVP GAVLVFLPGW
670 680 690 700 710 720
NLIYTMQKHL EMNPHFGSHR YQILPLHSQI PREEQRKVFD PVPVGVTKVI LSTNIAETSI
730 740 750 760 770 780
TINDVVYVID SCKQKVKLFT AHNNMTNYAT VWASKTNLEQ RKGRAGRVRP GFCFHLCSRA
790 800 810 820 830 840
RFERLETHMT PEMFRTPLHE IALSIKLLRL GGIGQFLAKA IEPPPLDAVI EAEHTLRELD
850 860 870 880 890 900
ALDANDELTP LGRILAKLPI EPRFGKMMIM GCIFYVGDAI CTIAAATCFP EPFINEGKRL
910 920 930 940 950 960
GYIHRNFAGN RFSDHVALLS VFQAWDDARM GGEEAEIRFC EHKRLNMATL RMTWEAKVQL
970 980 990 1000 1010 1020
KEILINSGFP EDCLLTQVFT NTGPDNNLDV VISLLAFGVY PNVCYHKEKR KILTTEGRNA
1030 1040 1050 1060 1070 1080
LIHKSSVNCP FSSQDMKYPS PFFVFGEKIR TRAISAKGMT LVTPLQLLLF ASKKVQSDGQ
1090 1100 1110 1120 1130 1140
IVLVDDWIKL QISHEAAACI TGLRAAMEAL VVEVTKQPAI ISQLDPVNER MLNMIRQISR
1150 1160 1170 1180 1190 1200
PSAAGINLMI GSTRYGDGPR PPKMARYDNG SGYRRGGSSY SGGGYGGGYS SGGYGSGGYG
1210 1220 1230 1240 1250 1260
GSANSFRAGY GAGVGGGYRG VSRGGFRGNS GGDYRGPSGG YRGSGGFQRG GGRGAYGTGY
1270
FGQGRGGGGY
Isoforms
- Isoform 2 of ATP-dependent RNA helicase ASequence View
10 20 30 40 50 60
MGDVKNFLYA WCGKRKMTPS YEIRAVGNKN RQKFMCEVQV EGYNYTGMGN STNKKDAQSN
70 80 90 100 110 120
AARDFVNYLV RINEIKSEEV PAFGVASPPP LTDTPDTTAN AEGDLPTTMG GPLPPHLALK
130 140 150 160 170 180
AENNSEVGAS GYGVPGPTWD RGANLKDYYS RKEEQEVQAT LESEEVDLNA GLHGNWTLEN
190 200 210 220 230 240
AKARLNQYFQ KEKIQGEYKY TQVGPDHNRS FIAEMTIYIK QLGRRIFARE HGSNKKLAAQ
250 260 270 280 290 300
SCALSLVRQL YHLGVVEAYS GLTKKKEGET VEPYKVNLSQ DLEHQLQNII QELNLEILPP
310 320 330 340 350 360
PEDPSVPVAL NIGKLAQFEP SQRQNQVGVV PWSPPQSNWN PWTSSNIDEG PLAFATPEQI
370 380 390 400 410 420
SMDLKNELMY QLEQDHDLQA ILQERELLPV KKFESEILEA ISQNSVVIIR GATGCGKTTQ
430 440 450 460 470 480
VPQFILDDFI QNDRAAECNI VVTQPRRISA VSVAERVAFE RGEEPGKSCG YSVRFESILP
490 500 510 520 530 540
RPHASIMFCT VGVLLRKLEA GIRGISHVIV DEIHERDINT DFLLVVLRDV VQAYPEVRIV
550 560 570 580 590 600
LMSATIDTSM FCEYFFNCPI IEVYGRTYPV QEYFLEDCIQ MTHFVPPPKD KKKKDKDDDG
610 620 630 640 650 660
GEDDDANCNL ICGDEYGPET RLSMSQLNEK ETPFELIEAL LKYIETLNVP GAVLVFLPGW
670 680 690 700 710 720
NLIYTMQKHL EMNPHFGSHR YQILPLHSQI PREEQRKVFD PVPVGVTKVI LSTNIAETSI
730 740 750 760 770 780
TINDVVYVID SCKQKVKLFT AHNNMTNYAT VWASKTNLEQ RKGRAGRVRP GFCFHLCSRA
790 800 810 820 830 840
RFERLETHMT PEMFRTPLHE IALSIKLLRL GGIGQFLAKA IEPPPLDAVI EAEHTLRELD
850 860 870 880 890 900
ALDANDELTP LGRILAKLPI EPRFGKMMIM GCIFYVGDAI CTIAAATCFP EPFINEGKRL
910 920 930 940 950 960
GYIHRNFAGN RFSDHVALLS VFQAWDDARM GGEEAEIRFC EHKRLNMATL RMTWEAKVQL
970 980 990 1000 1010 1020
KEILINSGFP EDCLLTQVFT NTGPDNNLDV VISLLAFGVY PNVCYHKEKR KILTTEGRNA
1030 1040 1050 1060 1070 1080
LIHKSSVNCP FSSQDMKYPS PFFVFGEKIR TRAISAKGMT LVTPLQLLLF ASKKVQSDGQ
1090 1100 1110 1120 1130 1140
IVLVDDWIKL QISHEAAACI TGLRAAMEAL VVEVTKQPAI ISQLDPVNER MLNMIRQISR
1150 1160 1170 1180 1190 1200
PSAAGINLMI GSTRYGDGPR PPKMARYDNG SGYRRGGSSY SGGGYGGGYS SGGYGSGGYG
1210 1220 1230 1240 1250 1260
GSANSFRAGY GAGVGGGYRG VSRGGFRGNS GGDYRGPSGG YRGSGGFQRG GGRGAYGTGY
1270
FGQGRGGGGY
Protein Neighborhood
Domains & Features
22 N-termini - 9 C-termini - 9 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q08211-1-unknown | MGDVKN... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q08211-2-acetylation | GDVKNF... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q08211-16-unknown | KMTPSY... | 16 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q08211-97-unknown | TTANAE... | 97 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q08211-97- | TTANAE... | 97 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q08211-97- | TTANAE... | 97 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q08211-97- | TTANAE... | 97 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q08211-97- | TTANAE... | 97 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q08211-97- | TTANAE... | 97 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q08211-111-unknown | GPLPPH... | 111 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6252 | |||
Q08211-121- | AENNSE... | 121 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
Q08211-129- | ASGYGV... | 129 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q08211-129- | ASGYGV... | 129 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q08211-129- | ASGYGV... | 129 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q08211-159- | ATLESE... | 159 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q08211-159- | ATLESE... | 159 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q08211-161-unknown | LESEEV... | 161 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11938 | |||
Q08211-162-unknown | ESEEVD... | 162 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14382 | |||
Q08211-163-unknown | SEEVDL... | 163 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11939 | |||
Q08211-168-unknown | LNAGLH... | 168 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2120 | |||
Q08211-168- | LNAGLH... | 168 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q08211-369-unknown | MYQLEQ... | 369 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14383 | |||
Q08211-820- | AIEPPP... | 820 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q08211-820- | AIEPPP... | 820 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q08211-820- | AIEPPP... | 820 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q08211-820- | AIEPPP... | 820 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q08211-820- | AIEPPP... | 820 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q08211-828-unknown | AVIEAE... | 828 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7736 | |||
Q08211-828-unknown | AVIEAE... | 828 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17865 | |||
Q08211-828- | AVIEAE... | 828 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q08211-828- | AVIEAE... | 828 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q08211-828- | AVIEAE... | 828 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q08211-829-unknown | VIEAEH... | 829 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17866 | |||
Q08211-906- | NFAGNR... | 906 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q08211-1032- | SSQDMK... | 1032 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q08211-1036-unknown | MKYPSP... | 1036 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72759 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PTTMGG | 110 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6252 | |||
...EVQATL | 160 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11938 | |||
...VQATLE | 161 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14382 | |||
...QATLES | 162 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11939 | |||
...SEEVDL | 167 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2120 | |||
...LKNELM | 368 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14383 | |||
...PPPLDA | 827 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7736 | |||
...PPPLDA | 827 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17865 | |||
...PPLDAV | 828 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17866 | |||
...GGGGY | 1270 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GGGGY | 1270 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68377 |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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