P78527: DNA-dependent protein kinase catalytic subunit

General Information

Protein names	- DNA-dependent protein kinase catalytic subunit - DNA-PK catalytic subunit - DNA-PKcs - 2.7.11.1 - DNPK1 - p460
Gene names	PRKDC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P78527

30 N-termini

19 C-termini

17 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGSGAGVRC SLLRLQETLS AADRCGAALA GHQLIRGLGQ ECVLSSSPAV LALQTSLVFS
        70         80         90        100        110        120
RDFGLLVFVR KSLNSIEFRE CREEILKFLC IFLEKMGQKI APYSVEIKNT CTSVYTKDRA
       130        140        150        160        170        180
AKCKIPALDL LIKLLQTFRS SRLMDEFKIG ELFSKFYGEL ALKKKIPDTV LEKVYELLGL
       190        200        210        220        230        240
LGEVHPSEMI NNAENLFRAF LGELKTQMTS AVREPKLPVL AGCLKGLSSL LCNFTKSMEE
       250        260        270        280        290        300
DPQTSREIFN FVLKAIRPQI DLKRYAVPSA GLRLFALHAS QFSTCLLDNY VSLFEVLLKW
       310        320        330        340        350        360
CAHTNVELKK AALSALESFL KQVSNMVAKN AEMHKNKLQY FMEQFYGIIR NVDSNNKELS
       370        380        390        400        410        420
IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQMFLTQT DTGDDRVYQM PSFLQSVASV
       430        440        450        460        470        480
LLYLDTVPEV YTPVLEHLVV MQIDSFPQYS PKMQLVCCRA IVKVFLALAA KGPVLRNCIS
       490        500        510        520        530        540
TVVHQGLIRI CSKPVVLPKG PESESEDHRA SGEVRTGKWK VPTYKDYVDL FRHLLSSDQM
       550        560        570        580        590        600
MDSILADEAF FSVNSSSESL NHLLYDEFVK SVLKIVEKLD LTLEIQTVGE QENGDEAPGV
       610        620        630        640        650        660
WMIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKQAE FFEPWVYSFS YELILQSTRL
       670        680        690        700        710        720
PLISGFYKLL SITVRNAKKI KYFEGVSPKS LKHSPEDPEK YSCFALFVKF GKEVAVKMKQ
       730        740        750        760        770        780
YKDELLASCL TFLLSLPHNI IELDVRAYVP ALQMAFKLGL SYTPLAEVGL NALEEWSIYI
       790        800        810        820        830        840
DRHVMQPYYK DILPCLDGYL KTSALSDETK NNWEVSALSR AAQKGFNKVV LKHLKKTKNL
       850        860        870        880        890        900
SSNEAISLEE IRIRVVQMLG SLGGQINKNL LTVTSSDEMM KSYVAWDREK RLSFAVPFRE
       910        920        930        940        950        960
MKPVIFLDVF LPRVTELALT ASDRQTKVAA CELLHSMVMF MLGKATQMPE GGQGAPPMYQ
       970        980        990       1000       1010       1020
LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVALL EAILDGIVDP
      1030       1040       1050       1060       1070       1080
VDSTLRDFCG RCIREFLKWS IKQITPQQQE KSPVNTKSLF KRLYSLALHP NAFKRLGASL
      1090       1100       1110       1120       1130       1140
AFNNIYREFR EEESLVEQFV FEALVIYMES LALAHADEKS LGTIQQCCDA IDHLCRIIEK
      1150       1160       1170       1180       1190       1200
KHVSLNKAKK RRLPRGFPPS ASLCLLDLVK WLLAHCGRPQ TECRHKSIEL FYKFVPLLPG
      1210       1220       1230       1240       1250       1260
NRSPNLWLKD VLKEEGVSFL INTFEGGGCG QPSGILAQPT LLYLRGPFSL QATLCWLDLL
      1270       1280       1290       1300       1310       1320
LAALECYNTF IGERTVGALQ VLGTEAQSSL LKAVAFFLES IAMHDIIAAE KCFGTGAAGN
      1330       1340       1350       1360       1370       1380
RTSPQEGERY NYSKCTVVVR IMEFTTTLLN TSPEGWKLLK KDLCNTHLMR VLVQTLCEPA
      1390       1400       1410       1420       1430       1440
SIGFNIGDVQ VMAHLPDVCV NLMKALKMSP YKDILETHLR EKITAQSIEE LCAVNLYGPD
      1450       1460       1470       1480       1490       1500
AQVDRSRLAA VVSACKQLHR AGLLHNILPS QSTDLHHSVG TELLSLVYKG IAPGDERQCL
      1510       1520       1530       1540       1550       1560
PSLDLSCKQL ASGLLELAFA FGGLCERLVS LLLNPAVLST ASLGSSQGSV IHFSHGEYFY
      1570       1580       1590       1600       1610       1620
SLFSETINTE LLKNLDLAVL ELMQSSVDNT KMVSAVLNGM LDQSFRERAN QKHQGLKLAT
      1630       1640       1650       1660       1670       1680
TILQHWKKCD SWWAKDSPLE TKMAVLALLA KILQIDSSVS FNTSHGSFPE VFTTYISLLA
      1690       1700       1710       1720       1730       1740
DTKLDLHLKG QAVTLLPFFT SLTGGSLEEL RRVLEQLIVA HFPMQSREFP PGTPRFNNYV
      1750       1760       1770       1780       1790       1800
DCMKKFLDAL ELSQSPMLLE LMTEVLCREQ QHVMEELFQS SFRRIARRGS CVTQVGLLES
      1810       1820       1830       1840       1850       1860
VYEMFRKDDP RLSFTRQSFV DRSLLTLLWH CSLDALREFF STIVVDAIDV LKSRFTKLNE
      1870       1880       1890       1900       1910       1920
STFDTQITKK MGYYKILDVM YSRLPKDDVH AKESKINQVF HGSCITEGNE LTKTLIKLCY
      1930       1940       1950       1960       1970       1980
DAFTENMAGE NQLLERRRLY HCAAYNCAIS VICCVFNELK FYQGFLFSEK PEKNLLIFEN
      1990       2000       2010       2020       2030       2040
LIDLKRRYNF PVEVEVPMER KKKYIEIRKE AREAANGDSD GPSYMSSLSY LADSTLSEEM
      2050       2060       2070       2080       2090       2100
SQFDFSTGVQ SYSYSSQDPR PATGRFRRRE QRDPTVHDDV LELEMDELNR HECMAPLTAL
      2110       2120       2130       2140       2150       2160
VKHMHRSLGP PQGEEDSVPR DLPSWMKFLH GKLGNPIVPL NIRLFLAKLV INTEEVFRPY
      2170       2180       2190       2200       2210       2220
AKHWLSPLLQ LAASENNGGE GIHYMVVEIV ATILSWTGLA TPTGVPKDEV LANRLLNFLM
      2230       2240       2250       2260       2270       2280
KHVFHPKRAV FRHNLEIIKT LVECWKDCLS IPYRLIFEKF SGKDPNSKDN SVGIQLLGIV
      2290       2300       2310       2320       2330       2340
MANDLPPYDP QCGIQSSEYF QALVNNMSFV RYKEVYAAAA EVLGLILRYV MERKNILEES
      2350       2360       2370       2380       2390       2400
LCELVAKQLK QHQNTMEDKF IVCLNKVTKS FPPLADRFMN AVFFLLPKFH GVLKTLCLEV
      2410       2420       2430       2440       2450       2460
VLCRVEGMTE LYFQLKSKDF VQVMRHRDDE RQKVCLDIIY KMMPKLKPVE LRELLNPVVE
      2470       2480       2490       2500       2510       2520
FVSHPSTTCR EQMYNILMWI HDNYRDPESE TDNDSQEIFK LAKDVLIQGL IDENPGLQLI
      2530       2540       2550       2560       2570       2580
IRNFWSHETR LPSNTLDRLL ALNSLYSPKI EVHFLSLATN FLLEMTSMSP DYPNPMFEHP
      2590       2600       2610       2620       2630       2640
LSECEFQEYT IDSDWRFRST VLTPMFVETQ ASQGTLQTRT QEGSLSARWP VAGQIRATQQ
      2650       2660       2670       2680       2690       2700
QHDFTLTQTA DGRSSFDWLT GSSTDPLVDH TSPSSDSLLF AHKRSERLQR APLKSVGPDF
      2710       2720       2730       2740       2750       2760
GKKRLGLPGD EVDNKVKGAA GRTDLLRLRR RFMRDQEKLS LMYARKGVAE QKREKEIKSE
      2770       2780       2790       2800       2810       2820
LKMKQDAQVV LYRSYRHGDL PDIQIKHSSL ITPLQAVAQR DPIIAKQLFS SLFSGILKEM
      2830       2840       2850       2860       2870       2880
DKFKTLSEKN NITQKLLQDF NRFLNTTFSF FPPFVSCIQD ISCQHAALLS LDPAAVSAGC
      2890       2900       2910       2920       2930       2940
LASLQQPVGI RLLEEALLRL LPAELPAKRV RGKARLPPDV LRWVELAKLY RSIGEYDVLR
      2950       2960       2970       2980       2990       3000
GIFTSEIGTK QITQSALLAE ARSDYSEAAK QYDEALNKQD WVDGEPTEAE KDFWELASLD
      3010       3020       3030       3040       3050       3060
CYNHLAEWKS LEYCSTASID SENPPDLNKI WSEPFYQETY LPYMIRSKLK LLLQGEADQS
      3070       3080       3090       3100       3110       3120
LLTFIDKAMH GELQKAILEL HYSQELSLLY LLQDDVDRAK YYIQNGIQSF MQNYSSIDVL
      3130       3140       3150       3160       3170       3180
LHQSRLTKLQ SVQALTEIQE FISFISKQGN LSSQVPLKRL LNTWTNRYPD AKMDPMNIWD
      3190       3200       3210       3220       3230       3240
DIITNRCFFL SKIEEKLTPL PEDNSMNVDQ DGDPSDRMEV QEQEEDISSL IRSCKFSMKM
      3250       3260       3270       3280       3290       3300
KMIDSARKQN NFSLAMKLLK ELHKESKTRD DWLVSWVQSY CRLSHCRSRS QGCSEQVLTV
      3310       3320       3330       3340       3350       3360
LKTVSLLDEN NVSSYLSKNI LAFRDQNILL GTTYRIIANA LSSEPACLAE IEEDKARRIL
      3370       3380       3390       3400       3410       3420
ELSGSSSEDS EKVIAGLYQR AFQHLSEAVQ AAEEEAQPPS WSCGPAAGVI DAYMTLADFC
      3430       3440       3450       3460       3470       3480
DQQLRKEEEN ASVIDSAELQ AYPALVVEKM LKALKLNSNE ARLKFPRLLQ IIERYPEETL
      3490       3500       3510       3520       3530       3540
SLMTKEISSV PCWQFISWIS HMVALLDKDQ AVAVQHSVEE ITDNYPQAIV YPFIISSESY
      3550       3560       3570       3580       3590       3600
SFKDTSTGHK NKEFVARIKS KLDQGGVIQD FINALDQLSN PELLFKDWSN DVRAELAKTP
      3610       3620       3630       3640       3650       3660
VNKKNIEKMY ERMYAALGDP KAPGLGAFRR KFIQTFGKEF DKHFGKGGSK LLRMKLSDFN
      3670       3680       3690       3700       3710       3720
DITNMLLLKM NKDSKPPGNL KECSPWMSDF KVEFLRNELE IPGQYDGRGK PLPEYHVRIA
      3730       3740       3750       3760       3770       3780
GFDERVTVMA SLRRPKRIII RGHDEREHPF LVKGGEDLRQ DQRVEQLFQV MNGILAQDSA
      3790       3800       3810       3820       3830       3840
CSQRALQLRT YSVVPMTSRL GLIEWLENTV TLKDLLLNTM SQEEKAAYLS DPRAPPCEYK
      3850       3860       3870       3880       3890       3900
DWLTKMSGKH DVGAYMLMYK GANRTETVTS FRKRESKVPA DLLKRAFVRM STSPEAFLAL
      3910       3920       3930       3940       3950       3960
RSHFASSHAL ICISHWILGI GDRHLNNFMV AMETGGVIGI DFGHAFGSAT QFLPVPELMP
      3970       3980       3990       4000       4010       4020
FRLTRQFINL MLPMKETGLM YSIMVHALRA FRSDPGLLTN TMDVFVKEPS FDWKNFEQKM
      4030       4040       4050       4060       4070       4080
LKKGGSWIQE INVAEKNWYP RQKICYAKRK LAGANPAVIT CDELLLGHEK APAFRDYVAV
      4090       4100       4110       4120
ARGSKDHNIR AQEPESGLSE ETQVKCLMDQ ATDPNILGRT WEGWEPWM

Isoforms

- Isoform 2 of DNA-dependent protein kinase catalytic subunit

Sequence View

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Protein Neighborhood

Domains & Features

30 N-termini - 19 C-termini - 17 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P78527-1-unknown	MAGSGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78527-1-unknown	MAGSGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86204
P78527-2-acetylation	AGSGAG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P78527-2-acetylation	AGSGAG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P78527-2-acetylation	AGSGAG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162549
P78527-96-unknown	MGQKIA...	96		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441157
P78527-96-unknown	MGQKIA...	96		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131215
P78527-209-unknown	TSAVRE...	209		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14315
P78527-209-unknown	TSAVRE...	209		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146932
P78527-492-unknown	SKPVVL...	492		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7696
P78527-492-unknown	SKPVVL...	492		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6184
P78527-492-unknown	SKPVVL...	492		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153321
P78527-861-unknown	SLGGQI...	861		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3929
P78527-861-unknown	SLGGQI...	861		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156713
P78527-1126-unknown	QCCDAI...	1126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7698
P78527-1126-unknown	QCCDAI...	1126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157466
P78527-1901-unknown	HGSCIT...	1901		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7700
P78527-1901-unknown	HGSCIT...	1901		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158688
P78527-1902-unknown	GSCITE...	1902		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3931
P78527-1902-unknown	GSCITE...	1902		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158693
P78527-2021-unknown	GPSYMS...	2021		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1984
P78527-2021-unknown	GPSYMS...	2021		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158803
P78527-2046-	STGVQS...	2046			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P78527-2046-unknown	STGVQS...	2046		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176720
P78527-2107-unknown	SLGPPQ...	2107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177798
P78527-2107-	SLGPPQ...	2107			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P78527-2606-unknown	FVETQA...	2606		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14317
P78527-2606-unknown	FVETQA...	2606		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159222
P78527-2609-unknown	TQASQG...	2609		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7702
P78527-2609-unknown	TQASQG...	2609		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159225
P78527-2700-unknown	FGKKRL...	2700		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11832
P78527-2700-unknown	FGKKRL...	2700		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159240
P78527-2714-unknown	NKVKGA...	2714		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11834
P78527-2714-unknown	NKVKGA...	2714		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1986
P78527-2714-unknown	NKVKGA...	2714		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159245
P78527-2767-unknown	AQVVLY...	2767		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11836
P78527-2767-unknown	AQVVLY...	2767		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159250
P78527-3015-	STASID...	3015			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P78527-3015-unknown	STASID...	3015		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175481
P78527-3205-unknown	SMNVDQ...	3205		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11838
P78527-3205-unknown	SMNVDQ...	3205		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159309
P78527-3205-	SMNVDQ...	3205			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P78527-3212-unknown	GDPSDR...	3212		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11840
P78527-3212-unknown	GDPSDR...	3212		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159313
P78527-3212-	GDPSDR...	3212			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P78527-3212-	GDPSDR...	3212			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P78527-3212-	GDPSDR...	3212			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P78527-3212-	GDPSDR...	3212			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P78527-3436-	SAELQA...	3436			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P78527-3436-	SAELQA...	3436			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P78527-3436-	SAELQA...	3436			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P78527-3436-	SAELQA...	3436			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P78527-3436-unknown	SAELQA...	3436		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175479
P78527-3541-	SFKDTS...	3541			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P78527-3541-unknown	SFKDTS...	3541		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177796
P78527-4063-unknown	ELLLGH...	4063		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11842
P78527-4063-unknown	ELLLGH...	4063		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159339

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ALKKKI	165	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441157
...ALKKKI	165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt111333
...LKTQMT	208	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14315
...LKTQMT	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130263
...LIRICS	491	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7696
...LIRICS	491	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6184
...LIRICS	491	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136745
...VQMLGS	860	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3929
...VQMLGS	860	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140201
...LGTIQQ	1125	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7698
...LGTIQQ	1125	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140964
...INQVFH	1900	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7700
...INQVFH	1900	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142192
...NQVFHG	1901	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3931
...NQVFHG	1901	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142197
...NGDSDG	2020	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1984
...NGDSDG	2020	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142307
...VLTPMF	2605	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14317
...VLTPMF	2605	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142726
...PMFVET	2608	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7702
...PMFVET	2608	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142729
...SVGPDF	2699	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11832
...SVGPDF	2699	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142744
...GDEVDN	2713	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11834
...GDEVDN	2713	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1986
...GDEVDN	2713	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142749
...KMKQDA	2766	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11836
...KMKQDA	2766	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142754
...LPEDNS	3204	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11838
...LPEDNS	3204	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142813
...NVDQDG	3211	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11840
...NVDQDG	3211	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142817
...SFDWKN	4014	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442177
...SFDWKN	4014	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt111331
...VITCDE	4062	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11842
...VITCDE	4062	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142843
...WEPWM	4128		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...WEPWM	4128	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...WEPWM	4128	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81822
...WEPWM	4128		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	208	TQMT.\|.TSAV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	491	RICS.\|.SKPV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	491	RICS.\|.SKPV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	860	MLGS.\|.SLGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	1125	TIQQ.\|.QCCD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	1900	QVFH.\|.HGSC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	1901	VFHG.\|.GSCI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	2020	DSDG.\|.GPSY	inferred from experiment	unknown	MEROPS	Nagata S	Teraoka H et al.:CPP32/Yama/apopain cleaves the ... (C14.003)	8804412,
GRAM_HUMAN	2605	TPMF.\|.FVET	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	2608	FVET.\|.TQAS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	2699	GPDF.\|.FGKK	inferred from experiment	unknown	MEROPS	Casciola-Rosen L	Andrade F et al.:Granzyme B directly and efficie... (S01.010)	9586635,
GRAB_HUMAN	2713	EVDN.\|.NKVK	inferred from experiment	unknown	MEROPS	Casciola-Rosen L	Andrade F et al.:Granzyme B directly and efficie... (S01.010)	9586635,
CASP3_HUMAN	2713	EVDN.\|.NKVK	inferred from experiment	unknown	MEROPS	Lavin MF	Song Q et al.:Interleukin-1 beta-converting e... (C14.003)	8760815,
GRAB_HUMAN	2766	KQDA.\|.AQVV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	3204	EDNS.\|.SMNV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	3211	DQDG.\|.GDPS	inferred from experiment	unknown	MEROPS	Casciola-Rosen L	Andrade F et al.:Granzyme B directly and efficie... (S01.010)	9586635,
GRAB_HUMAN	4062	TCDE.\|.ELLL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)