P22234: Multifunctional protein ADE2

General Information

Protein names	- Multifunctional protein ADE2 - Phosphoribosylaminoimidazole-succinocarboxamide synthase - 6.3.2.6 - SAICAR synthetase - Phosphoribosylaminoimidazole carboxylase - 4.1.1.21 - AIR carboxylase - AIRC
Gene names	PAICS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22234

15 N-termini

9 C-termini

13 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATAEVLNIG KKLYEGKTKE VYELLDSPGK VLLQSKDQIT AGNAARKNHL EGKAAISNKI
        70         80         90        100        110        120
TSCIFQLLQE AGIKTAFTRK CGETAFIAPQ CEMIPIEWVC RRIATGSFLK RNPGVKEGYK
       130        140        150        160        170        180
FYPPKVELFF KDDANNDPQW SEEQLIAAKF CFAGLLIGQT EVDIMSHATQ AIFEILEKSW
       190        200        210        220        230        240
LPQNCTLVDM KIEFGVDVTT KEIVLADVID NDSWRLWPSG DRSQQKDKQS YRDLKEVTPE
       250        260        270        280        290        300
GLQMVKKNFE WVAERVELLL KSESQCRVVV LMGSTSDLGH CEKIKKACGN FGIPCELRVT
       310        320        330        340        350        360
SAHKGPDETL RIKAEYEGDG IPTVFVAVAG RSNGLGPVMS GNTAYPVISC PPLTPDWGVQ
       370        380        390        400        410        420
DVWSSLRLPS GLGCSTVLSP EGSAQFAAQI FGLSNHLVWS KLRASILNTW ISLKQADKKI

RECNL

Isoforms

- Isoform 2 of Multifunctional protein ADE2

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 9 C-termini - 13 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22234-2-unknown	MATAEV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22234-1-unknown	MATAEV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86673
P22234-2-Acetylation	ATAEVL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22234-2-Acetylation	ATAEVL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P22234-2-Acetylation	ATAEVL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P22234-2-Acetylation	ATAEVL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110416
P22234-27-unknown	SPGKVL...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1731
P22234-27-unknown	SPGKVL...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137359
P22234-35-unknown	SKDQIT...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5671
P22234-35-unknown	SKDQIT...	35		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137947
P22234-233-	DLKEVT...	233			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P22234-233-	DLKEVT...	233			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P22234-233-	DLKEVT...	233			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P22234-233-	DLKEVT...	233			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P22234-233-unknown	DLKEVT...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164385
P22234-272-unknown	MGSTSD...	272		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5673
P22234-272-unknown	MGSTSD...	272		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3689
P22234-272-unknown	MGSTSD...	272		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149305
P22234-273-unknown	GSTSDL...	273		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5675
P22234-273-unknown	GSTSDL...	273		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3691
P22234-273-unknown	GSTSDL...	273		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7363
P22234-273-unknown	GSTSDL...	273		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149338
P22234-274-unknown	STSDLG...	274		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5677
P22234-274-unknown	STSDLG...	274		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3693
P22234-274-unknown	STSDLG...	274		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7365
P22234-274-unknown	STSDLG...	274		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149362
P22234-301-unknown	SAHKGP...	301		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5679
P22234-301-unknown	SAHKGP...	301		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150072
P22234-302-unknown	AHKGPD...	302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5681
P22234-302-unknown	AHKGPD...	302		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150096
P22234-320-	GIPTVF...	320			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22234-320-unknown	GIPTVF...	320		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171857
P22234-372-unknown	LGCSTV...	372		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3695
P22234-372-unknown	LGCSTV...	372		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151585

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YELLDS	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1731
...YELLDS	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120304
...KVLLQS	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5671
...KVLLQS	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120956
...RVVVLM	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5673
...RVVVLM	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3689
...RVVVLM	271	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132690
...VVVLMG	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5675
...VVVLMG	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3691
...VVVLMG	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7363
...VVVLMG	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132723
...VVLMGS	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5677
...VVLMGS	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3693
...VVLMGS	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7365
...VVLMGS	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132746
...ELRVTS	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5679
...ELRVTS	300	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133464
...LRVTSA	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5681
...LRVTSA	301	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133488
...RLPSGL	371	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3695
...RLPSGL	371	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134991
...RECNL	425	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RECNL	425	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82291

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	26	LLDS.\|.SPGK	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> PUR6_HUMAN @26
CATL1_HUMAN	34	LLQS.\|.SKDQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	271	VVLM.\|.MGST	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	271	VVLM.\|.MGST	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	272	VLMG.\|.GSTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	272	VLMG.\|.GSTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	272	VLMG.\|.GSTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	273	LMGS.\|.STSD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	273	LMGS.\|.STSD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	273	LMGS.\|.STSD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	300	RVTS.\|.SAHK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	301	VTSA.\|.AHKG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	371	PSGL.\|.LGCS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)