Q9NR45: Sialic acid synthase

General Information

Protein names	- Sialic acid synthase - N-acetylneuraminate synthase - 2.5.1.56 - N-acetylneuraminate-9-phosphate synthase - 2.5.1.57 - N-acetylneuraminic acid phosphate synthase - N-acetylneuraminic acid synthase
Gene names	NANS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NR45

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPLELELCPG RWVGGQHPCF IIAEIGQNHQ GDLDVAKRMI RMAKECGADC AKFQKSELEF
        70         80         90        100        110        120
KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYRELQR YAEEVGIFFT ASGMDEMAVE
       130        140        150        160        170        180
FLHELNVPFF KVGSGDTNNF PYLEKTAKKG RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC
       190        200        210        220        230        240
FLQCTSAYPL QPEDVNLRVI SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT
       250        260        270        280        290        300
LDKTWKGSDH SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK
       310        320        330        340        350
IPEGTILTMD MLTVKVGEPK GYPPEDIFNL VGKKVLVTVE EDDTIMEELV DNHGKKIKS

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NR45-1-unknown	MPLELE...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NR45-2-unknown	PLELEL...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NR45-2-unknown	PLELEL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NR45-2-unknown	PLELEL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NR45-27-unknown	QNHQGD...	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6798
Q9NR45-27-unknown	QNHQGD...	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8101
Q9NR45-90-unknown	FSHDQY...	90	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8102
Q9NR45-193-unknown	EDVNLR...	193	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404642

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IAEIGQ	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6798
...IAEIGQ	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8101
...KRHLEF	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8102
...TKQLLP	281	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404107
...KKIKS	359	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	26	EIGQ.\|.QNHQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	26	EIGQ.\|.QNHQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	89	HLEF.\|.FSHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)