O75175: CCR4-NOT transcription complex subunit 3
Protein names | - CCR4-NOT transcription complex subunit 3 - CCR4-associated factor 3 - Leukocyte receptor cluster member 2 |
---|---|
Gene names | CNOT3 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O75175 |
9
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD
70 80 90 100 110 120
QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQKE
130 140 150 160 170 180
KEEVGQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV
190 200 210 220 230 240
RMLETILRML DNDSILVDAI RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA
250 260 270 280 290 300
TSPPSHSHME DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP
310 320 330 340 350 360
AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP SALGPKASPA
370 380 390 400 410 420
PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG GGSGGGGSSS SSNSSAGGGA
430 440 450 460 470 480
GKQNGATSYS SVVADSPAEV ALSSSGGNNA SSQALGPPSG PHNPPPSTSK EPSAAAPTGA
490 500 510 520 530 540
GGVAPGSGNN SGGPSLLVPL PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL
550 560 570 580 590 600
SSLKSMAERA AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC
610 620 630 640 650 660
PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH QMPPPHSDTV
670 680 690 700 710 720
EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT KYMMWFQRHE EPKTITDEFE
730 740 750
QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR DLQ
Isoforms
- Isoform 2 of CCR4-NOT transcription complex subunit 3 - Isoform 3 of CCR4-NOT transcription complex subunit 3Sequence View
10 20 30 40 50 60
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD
70 80 90 100 110 120
QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQKE
130 140 150 160 170 180
KEEVGQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV
190 200 210 220 230 240
RMLETILRML DNDSILVDAI RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA
250 260 270 280 290 300
TSPPSHSHME DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP
310 320 330 340 350 360
AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP SALGPKASPA
370 380 390 400 410 420
PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG GGSGGGGSSS SSNSSAGGGA
430 440 450 460 470 480
GKQNGATSYS SVVADSPAEV ALSSSGGNNA SSQALGPPSG PHNPPPSTSK EPSAAAPTGA
490 500 510 520 530 540
GGVAPGSGNN SGGPSLLVPL PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL
550 560 570 580 590 600
SSLKSMAERA AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC
610 620 630 640 650 660
PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH QMPPPHSDTV
670 680 690 700 710 720
EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT KYMMWFQRHE EPKTITDEFE
730 740 750
QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR DLQ
10 20 30 40 50 60
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD
70 80 90 100 110 120
QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQKE
130 140 150 160 170 180
KEEVGQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV
190 200 210 220 230 240
RMLETILRML DNDSILVDAI RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA
250 260 270 280 290 300
TSPPSHSHME DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP
310 320 330 340 350 360
AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP SALGPKASPA
370 380 390 400 410 420
PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG GGSGGGGSSS SSNSSAGGGA
430 440 450 460 470 480
GKQNGATSYS SVVADSPAEV ALSSSGGNNA SSQALGPPSG PHNPPPSTSK EPSAAAPTGA
490 500 510 520 530 540
GGVAPGSGNN SGGPSLLVPL PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL
550 560 570 580 590 600
SSLKSMAERA AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC
610 620 630 640 650 660
PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH QMPPPHSDTV
670 680 690 700 710 720
EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT KYMMWFQRHE EPKTITDEFE
730 740 750
QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR DLQ
Protein Neighborhood
Domains & Features
9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O75175-1-unknown | MADKRK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O75175-1-unknown | MADKRK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt71177 | |||
O75175-182-unknown | MLETIL... | 182 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt71178 | |||
O75175-182-unknown | MLETIL... | 182 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96356 | |||
O75175-342-unknown | GVPAPA... | 342 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168035 | |||
O75175-342-unknown | GVPAPA... | 342 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168036 | |||
O75175-342- | GVPAPA... | 342 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O75175-342- | GVPAPA... | 342 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O75175-342- | GVPAPA... | 342 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
O75175-342- | GVPAPA... | 342 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75175-441- | ALSSSG... | 441 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
O75175-441-unknown | ALSSSG... | 441 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165702 | |||
O75175-441-unknown | ALSSSG... | 441 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165703 | |||
O75175-551-unknown | AISSGI... | 551 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174179 | |||
O75175-551-unknown | AISSGI... | 551 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174180 | |||
O75175-551- | AISSGI... | 551 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O75175-599-unknown | VCPLGP... | 599 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5222 | |||
O75175-599-unknown | VCPLGP... | 599 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152301 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PLSLGV | 598 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5222 | |||
...PLSLGV | 598 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135712 | |||
...DRDLQ | 753 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 598 | SLGV.|.VCPL | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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