Q96P11: Probable 28S rRNA (cytosine-C(5))-methyltransferase

General Information

Protein names	- Probable 28S rRNA (cytosine-C(5))-methyltransferase - 2.1.1.- {ECO:0000305\|PubMed:23913415} - NOL1-related protein - NOL1R - NOL1/NOP2/Sun domain family member 5 - Williams-Beuren syndrome chromosomal region 20A protein
Gene names	NSUN5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96P11

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Putative methyltransferase NSUN5 - Isoform 3 of Putative methyltransferase NSUN5 - Isoform 4 of Putative methyltransferase NSUN5 - Isoform 5 of Putative methyltransferase NSUN5 - Isoform 2 of Probable 28S rRNA (cytosine-C(5))-methyltransferase - Isoform 3 of Probable 28S rRNA (cytosine-C(5))-methyltransferase - Isoform 4 of Probable 28S rRNA (cytosine-C(5))-methyltransferase - Isoform 5 of Probable 28S rRNA (cytosine-C(5))-methyltransferase

Sequence View

        10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR         10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR         10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR         10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR         10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR         10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR         10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR         10         20         30         40         50         60
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL
        70         80         90        100        110        120
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED
       130        140        150        160        170        180
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL
       190        200        210        220        230        240
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK
       250        260        270        280        290        300
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH
       310        320        330        340        350        360
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS
       370        380        390        400        410        420
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA

VIERVEVPR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96P11-2-unknown	MGLYAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96P11-2-unknown	MGLYAA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96P11-2-unknown	MGLYAA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96P11-2-unknown	MGLYAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174124
Q96P11-2-unknown	MGLYAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174125
Q96P11-2-unknown	MGLYAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174126
Q96P11-1-unknown	MGLYAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83393
Q96P11-1-unknown	MGLYAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83395
Q96P11-1-unknown	MGLYAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83396
Q96P11-2-	GLYAAA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96P11-2-Acetylation	GLYAAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96P11-2-Acetylation	GLYAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110955
Q96P11-2-Acetylation	GLYAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110956
Q96P11-2-Acetylation	GLYAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110957
Q96P11-126-unknown	SRPGPA...	126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6687
Q96P11-126-unknown	SRPGPA...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140538
Q96P11-126-unknown	SRPGPA...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141696
Q96P11-126-unknown	SRPGPA...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143720
Q96P11-126-unknown	SRPGPA...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143721

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LLEVGS	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6687
...LLEVGS	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123669
...LLEVGS	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126963
...LLEVGS	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126964
...VEVPR	429	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VEVPR	429	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79014

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	125	EVGS.\|.SRPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)