Q9Y251: Heparanase
Protein names | - Heparanase - 3.2.1.166 - Endo-glucoronidase - Heparanase-1 - Hpa1 - Heparanase 8 kDa subunit - Heparanase 50 kDa subunit |
---|---|
Gene names | HPSE |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9Y251 |
16
N-termini
15
C-termini
14
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT
70 80 90 100 110 120
IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS
130 140 150 160 170 180
QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS
190 200 210 220 230 240
GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS
250 260 270 280 290 300
QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL
310 320 330 340 350 360
NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA
370 380 390 400 410 420
AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM
430 440 450 460 470 480
ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL
490 500 510 520 530 540
RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA
ACI
Isoforms
- Isoform 2 of Heparanase - Isoform 3 of Heparanase - Isoform 4 of HeparanaseSequence View
10 20 30 40 50 60
MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT
70 80 90 100 110 120
IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS
130 140 150 160 170 180
QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS
190 200 210 220 230 240
GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS
250 260 270 280 290 300
QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL
310 320 330 340 350 360
NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA
370 380 390 400 410 420
AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM
430 440 450 460 470 480
ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL
490 500 510 520 530 540
RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA
ACI
10 20 30 40 50 60
MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT
70 80 90 100 110 120
IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS
130 140 150 160 170 180
QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS
190 200 210 220 230 240
GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS
250 260 270 280 290 300
QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL
310 320 330 340 350 360
NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA
370 380 390 400 410 420
AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM
430 440 450 460 470 480
ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL
490 500 510 520 530 540
RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA
ACI
10 20 30 40 50 60
MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT
70 80 90 100 110 120
IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS
130 140 150 160 170 180
QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS
190 200 210 220 230 240
GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS
250 260 270 280 290 300
QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL
310 320 330 340 350 360
NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA
370 380 390 400 410 420
AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM
430 440 450 460 470 480
ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL
490 500 510 520 530 540
RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA
ACI
Protein Neighborhood
Domains & Features
16 N-termini - 15 C-termini - 14 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9Y251-1-unknown | MLLRSK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt77255 | |||
Q9Y251-1-unknown | MLLRSK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt77256 | |||
Q9Y251-1-unknown | MLLRSK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt77257 | |||
Q9Y251-36-unknown | QDVVDL... | 36 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9Y251-36-unknown | QDVVDL... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115290 | |||
Q9Y251-36-unknown | QDVVDL... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115291 | |||
Q9Y251-36-unknown | QDVVDL... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115292 | |||
Q9Y251-110-unknown | STFEER... | 110 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6876 | |||
Q9Y251-110-unknown | STFEER... | 110 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142963 | |||
Q9Y251-110-unknown | STFEER... | 110 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142965 | |||
Q9Y251-110-unknown | STFEER... | 110 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142967 | |||
Q9Y251-113-unknown | EERSYW... | 113 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6880 | |||
Q9Y251-113-unknown | EERSYW... | 113 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143143 | |||
Q9Y251-113-unknown | EERSYW... | 113 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143144 | |||
Q9Y251-113-unknown | EERSYW... | 113 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143145 | |||
Q9Y251-114-unknown | ERSYWQ... | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6884 | |||
Q9Y251-114-unknown | ERSYWQ... | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143202 | |||
Q9Y251-114-unknown | ERSYWQ... | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143203 | |||
Q9Y251-114-unknown | ERSYWQ... | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143204 | |||
Q9Y251-115-unknown | RSYWQS... | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6888 | |||
Q9Y251-115-unknown | RSYWQS... | 115 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143254 | |||
Q9Y251-115-unknown | RSYWQS... | 115 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143255 | |||
Q9Y251-115-unknown | RSYWQS... | 115 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143256 | |||
Q9Y251-118-unknown | WQSQVN... | 118 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6892 | |||
Q9Y251-118-unknown | WQSQVN... | 118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143395 | |||
Q9Y251-118-unknown | WQSQVN... | 118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143396 | |||
Q9Y251-118-unknown | WQSQVN... | 118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143397 | |||
Q9Y251-119-unknown | QSQVNQ... | 119 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6896 | |||
Q9Y251-119-unknown | QSQVNQ... | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143443 | |||
Q9Y251-119-unknown | QSQVNQ... | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143444 | |||
Q9Y251-119-unknown | QSQVNQ... | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143445 | |||
Q9Y251-120-unknown | SQVNQD... | 120 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6900 | |||
Q9Y251-120-unknown | SQVNQD... | 120 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143493 | |||
Q9Y251-120-unknown | SQVNQD... | 120 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143494 | |||
Q9Y251-120-unknown | SQVNQD... | 120 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143495 | |||
Q9Y251-131-unknown | SIPPDV... | 131 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6904 | |||
Q9Y251-131-unknown | SIPPDV... | 131 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143951 | |||
Q9Y251-131-unknown | SIPPDV... | 131 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143952 | |||
Q9Y251-131-unknown | SIPPDV... | 131 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143953 | |||
Q9Y251-141-unknown | RLEWPY... | 141 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6908 | |||
Q9Y251-141-unknown | RLEWPY... | 141 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144385 | |||
Q9Y251-141-unknown | RLEWPY... | 141 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144386 | |||
Q9Y251-141-unknown | RLEWPY... | 141 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144387 | |||
Q9Y251-144-unknown | WPYQEQ... | 144 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6912 | |||
Q9Y251-144-unknown | WPYQEQ... | 144 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144468 | |||
Q9Y251-144-unknown | WPYQEQ... | 144 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144469 | |||
Q9Y251-144-unknown | WPYQEQ... | 144 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144471 | |||
Q9Y251-147-unknown | QEQLLL... | 147 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6916 | |||
Q9Y251-147-unknown | QEQLLL... | 147 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144583 | |||
Q9Y251-147-unknown | QEQLLL... | 147 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144584 | |||
Q9Y251-148-unknown | EQLLLR... | 148 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6920 | |||
Q9Y251-148-unknown | EQLLLR... | 148 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144617 | |||
Q9Y251-148-unknown | EQLLLR... | 148 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144618 | |||
Q9Y251-149-unknown | QLLLRE... | 149 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6924 | |||
Q9Y251-149-unknown | QLLLRE... | 149 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144661 | |||
Q9Y251-149-unknown | QLLLRE... | 149 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144662 | |||
Q9Y251-158-unknown | KKFKNS... | 158 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9Y251-158-unknown | KKFKNS... | 158 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6928 | |||
Q9Y251-158-unknown | KKFKNS... | 158 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115972 | |||
Q9Y251-158-unknown | KKFKNS... | 158 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115973 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...DPKKES | 109 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...DPKKES | 109 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6876 | |||
...DPKKES | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91526 | |||
...DPKKES | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91527 | |||
...DPKKES | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91528 | |||
...KESTFE | 112 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6880 | |||
...KESTFE | 112 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126365 | |||
...KESTFE | 112 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126366 | |||
...KESTFE | 112 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126367 | |||
...ESTFEE | 113 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6884 | |||
...ESTFEE | 113 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126428 | |||
...ESTFEE | 113 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126429 | |||
...ESTFEE | 113 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126430 | |||
...STFEER | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6888 | |||
...STFEER | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126484 | |||
...STFEER | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126485 | |||
...STFEER | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126486 | |||
...EERSYW | 117 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6892 | |||
...EERSYW | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126628 | |||
...EERSYW | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126629 | |||
...EERSYW | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126630 | |||
...ERSYWQ | 118 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6896 | |||
...ERSYWQ | 118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126676 | |||
...ERSYWQ | 118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126677 | |||
...ERSYWQ | 118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126678 | |||
...RSYWQS | 119 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6900 | |||
...RSYWQS | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126727 | |||
...RSYWQS | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126728 | |||
...RSYWQS | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126729 | |||
...ICKYGS | 130 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6904 | |||
...ICKYGS | 130 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127194 | |||
...ICKYGS | 130 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127195 | |||
...ICKYGS | 130 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127196 | |||
...VEEKLR | 140 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6908 | |||
...VEEKLR | 140 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127648 | |||
...VEEKLR | 140 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127649 | |||
...VEEKLR | 140 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127650 | |||
...KLRLEW | 143 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6912 | |||
...KLRLEW | 143 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127732 | |||
...KLRLEW | 143 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127733 | |||
...KLRLEW | 143 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127735 | |||
...LEWPYQ | 146 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6916 | |||
...LEWPYQ | 146 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127850 | |||
...LEWPYQ | 146 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127851 | |||
...LEWPYQ | 146 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127852 | |||
...EWPYQE | 147 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6920 | |||
...EWPYQE | 147 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127884 | |||
...EWPYQE | 147 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127885 | |||
...EWPYQE | 147 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127887 | |||
...WPYQEQ | 148 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6924 | |||
...WPYQEQ | 148 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127928 | |||
...WPYQEQ | 148 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127929 | |||
...WPYQEQ | 148 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127930 | |||
...REHYQK | 157 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6928 | |||
...REHYQK | 157 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128338 | |||
...REHYQK | 157 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128339 | |||
...REHYQK | 157 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155053 | |||
...VAACI | 543 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...VAACI | 543 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt72874 | |||
...VAACI | 543 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt72873 |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|