Q9NX58: Cell growth-regulating nucleolar protein

General Information

Protein names	- Cell growth-regulating nucleolar protein
Gene names	LYAR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NX58

7 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK CISEDQKYGG
        70         80         90        100        110        120
KGYEGKTHKG DIKQQAWIQK ISELIKRPNV SPKVRELLEQ ISAFDNVPRK KAKFQNWMKN
       130        140        150        160        170        180
SLKVHNESIL DQVWNIFSEA SNSEPVNKEQ DQRPLHPVAN PHAEISTKVP ASKVKDAVEQ
       190        200        210        220        230        240
QGEVKKNKRE RKEERQKKRK REKKELKLEN HQENSRNQKP KKRKKGQEAD LEAGGEEVPE
       250        260        270        280        290        300
ANGSAGKRSK KKKQRKDSAS EEEAHVGAGK RKRRHSEVET DSKKKKMKLP EHPEGGEPED
       310        320        330        340        350        360
DEAPAKGKFN WKGTIKAILK QAPDNEITIK KLRKKVLAQY YTVTDEHHRS EEELLVIFNK
       370
KISKNPTFKL LKDKVKLVK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NX58-1-unknown	MVFFTC...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NX58-2-unknown	VFFTCN...	2		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NX58-2-unknown	VFFTCN...	2		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NX58-160-unknown	NPHAEI...	160	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6820
Q9NX58-160-unknown	NPHAEI...	160	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8114
Q9NX58-172-unknown	SKVKDA...	172	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15062
Q9NX58-207-unknown	KLENHQ...	207	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15063
Q9NX58-243-unknown	GSAGKR...	243	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13433
Q9NX58-287-	MKLPEH...	287		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QAWIQK	79	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420902
...LHPVAN	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6820
...LHPVAN	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8114
...TKVPAS	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15062
...EKKELK	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15063
...VPEANG	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13433
...VKLVK	379	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	159	PVAN.\|.NPHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	159	PVAN.\|.NPHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	171	VPAS.\|.SKVK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	206	KELK.\|.KLEN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	242	EANG.\|.GSAG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)